A5076972403- Genetic Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- Celiac Disease Research and Management
- Neurological Disorders and Treatments
- Retinal Development and Disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Neurology and Historical Studies
- Parkinson's Disease and Spinal Disorders
- Multiple Sclerosis Research Studies
- Hereditary Neurological Disorders
- Genomics and Rare Diseases
- Dermatology and Skin Diseases
- Neurological disorders and treatments
- Clinical practice guidelines implementation
- Glycogen Storage Diseases and Myoclonus
- Parkinson's Disease Mechanisms and Treatments
- Pain Mechanisms and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Neurological diseases and metabolism
- Retinal and Macular Surgery
- 14-3-3 protein interactions
- Health, Environment, Cognitive Aging
- Hallucinations in medical conditions
- Moyamoya disease diagnosis and treatment
- Restless Legs Syndrome Research
Kirov State Medical Academy
2020-2023
Privolzhsky Research Medical University
2000-2022
Samara State Medical University
2021
Rare diseases affect up to 29 million people in the European Union, and almost 50% of them nervous system or muscles. Delays diagnosis treatment onset insufficient choices are common. Clinical practice guidelines (CPGs) may improve patients optimize care pathways, delivering best scientific evidence all clinicians treating these patients. Recommendations set for developing reporting high-quality CPGs on rare neurological (RNDs) within Academy Neurology (EAN), through a consensus procedure.A...
Increased aging of the population makes problems diagnosis and treatment neurodegenerative diseases socially more significant.The ability to use retina as a "window" central nervous system has attracted great attention in recent years.Optical coherence tomography (OCT) is non-invasive method for vivo studies various conditions generate high-resolution images tissue cross sections under study.Retinal OCT parameters are considered be potential surrogate biomarkers early-stage disorders, have...
to study the prevalence of migraine among patients with celiac disease (CD) and clinical features «gluten migraine» syndrome assess efficacy gluten diet in its treatment.Authors examined 200 CD (main group) 100 reflux esophagitis without (control group). All fulfilled headache diary during three months before diagnosis was made six diet.CD group had four times more often than control (48.5%; p<0.001). In attacks were 2.5 frequent (р=0.004), but duration less long, 8 hours average. The...
Celiac disease is widespread autoimmune disease, which develops in genetically predisposed individuals case of gluten intake and manifests as enteropathy extraintestinal signs or without symptoms. recognized one the most common genetic diseases world with about 1% prevalence. The review organizes literature data concerning epidemiology, pathogenesis, clinical presentation, diagnosis treatment celiac disease. historical geographical features prevalence associated wheat consumption human...
Background: The purpose of this study was to analyze optical coherence tomography (OCT) parameters the choroid and retina in subjects with pre-manifest manifest Huntington's disease (HD).
 Methods: In case-control study, retinal patients genetically confirmed HD healthy controls were evaluated using spectral-domain (SD-OCT). Genetic neurological assessments performed besides a thorough ophthalmological examination. Contrast Sensitivity (CS) logarithm Freiburg Vision Test. association...
In a COVID-19 pandemic, neurologist needs to be able assess the risks of virus infection in patients with individual neurological diseases. The review presents categories risk groups from Association British Neurologists for neuromuscular diseases, multiple sclerosis and other autoimmune diseases central nervous system, stroke, epilepsy Parkinson’s disease. management are analyzed detail. use disease modifying drugs, treatment stroke discussed. data international guidelines presented.
Dementias are much more rarely encountered in young than older people. However, the highest percentage of dementias is reversible patients. The diagnosis cognitive impairments this patient category makes it possible to identify underlying disease and perform adequate therapy at their early stage. clinical features that most common a age possibilities covered. authors describe own observations patients with neuroAIDS, Huntington’s disease, or multiple sclerosis.
Neuromyelitis optica spectrum disorders (NMOSD) comprise a group of autoimmune inflammatory demyelinating diseases the central nervous system that manifest as optic neuritis and transverse myelitis. Its manifestation in form makes early diagnosis difficult because neuroimaging spinal cord is not part routine examination algorithm for such patients. This article presents results comprehensive ophthalmological 4 patients (8 eyes) diagnosed with NMSOD. Optic was disease debut 3 had 1-2...
Transthyretin family amyloid polyneuropathy (TTR-FAP) is a progressive, ultimately fatal disease. It manifests itself primarily with sensory, motor and autonomic and/or cardiomyopathy caused by extracellular deposition of insoluble fibrils in the endoneurium. The cause TTR-FAP mutation gene encoding transthyretin, more than 100 types mutations are known. Given phenotypic diversity TTR-FAP, it difficult for clinicians to make this diagnosis. An erroneous diagnosis frequent occurrence, risking...
The purpose of this review is to analyze the data modern literature on pathological postural postures in neurodegenerative diseases. This provides prevalence, clinical presentation, and treatment axial deformities parkinsonism other It also discusses possible pathophysiological mechanisms that require further study. Postural were divided into sagittal or frontal plane accordance with which deformity predominates. most common positions diseases are camptocormia, Pisa syndrome, antecollis,...
The paper gives a brief clinical characterization of hereditary cerebellar ataxias running with polyneuropathy. Particular attention is paid to the pathogenesis, presentation, and treatment gluten ataxia. A mutant gene concurrent symptoms are indicated. differential diagnosis should be started by ruling out nature disease, which verified molecular genetic testing. In recent years, some diseases manifesting themselves concurrence ataxia polyneuropathy have been replenished description new...
Coeliac disease (CD) has been associated with various neurological disorders, the most common being neuropathy, ataxia and migraine. The aims of present study were to assess following: 1) prevalence migraine in patients affected by CD 2) effects a gluten free diet 376 had direct interviews full physical examinations. diagnosis was based on criteria IHS 1988. confirmed endoscopically serum IgG antitransglutaminase (TgA) IgA antiendomysia (EmA). Control group consisted 234 suffering from...
<h3>Background</h3> Contradictory data on retinal and choroidal thinning were found in Huntington's disease (HD). <h3>Aims</h3> The purpose of the study is to analyze morphology HD using optical coherence tomography (OCT), investigate correlation with clinical evaluate OCT as a biomarker pre-manifest HD. <h3>Methods</h3> A cross-sectional was performed foveal thickness, thickness 9 areas macular zone, ganglion cells complex (GCC) peripapillary nerve fiber layer (RNFL) healthy controls....
Purpose : to investigate the choroidal and retinal morphology in Huntington's disease (HD) using optical coherence tomography (OCT) analyze how parameters studied correlate with clinical data. Material methods . The study included two groups of subjects, (1) 44 HD patients, averagely aged 37.6 ± 10.2 yrs, (2) 31 healthy volunteers, 37.3 10.8 yrs. had matching age, sex distribution, intraocular pressure mean refractive error. In group, 21 patients pre-manifest 23, manifest stage. All...
Polyneuropathy in patients with diabetes mellitus is manifested by a lesion of peripheral sensory, motor and autonomic nervous system. Different severity damage fibers typical atypical forms diabetic polyneuropathy, requires differentiated approach to therapy, but not the rejection its implementation. In an interdisciplinary consensus, consultations are held physicians from different regions Russian Federation, modern methods diagnosing assessing polyneuropathies, which determine algorithm...