A5053673450- Viral Infections and Immunology Research
- Peripheral Neuropathies and Disorders
- Whipple's Disease and Interleukins
- Infectious Diseases and Tuberculosis
- SARS-CoV-2 and COVID-19 Research
- Multiple Sclerosis Research Studies
- Neurogenetic and Muscular Disorders Research
- Bacterial biofilms and quorum sensing
- Cardiac Arrest and Resuscitation
- PI3K/AKT/mTOR signaling in cancer
- Plant Pathogenic Bacteria Studies
- Hippo pathway signaling and YAP/TAZ
- Traumatic Brain Injury Research
- Congenital heart defects research
- Children's Physical and Motor Development
- Microtubule and mitosis dynamics
- Infectious Encephalopathies and Encephalitis
- Infective Endocarditis Diagnosis and Management
- Infections and bacterial resistance
- Celiac Disease Research and Management
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Infant Development and Preterm Care
- Glioma Diagnosis and Treatment
- Polyomavirus and related diseases
University Medical Center Groningen
2016-2025
University of Groningen
2016-2025
Erasmus MC
2021
University of Pennsylvania
2013
Enterovirus-D68 (EV-D68) is a respiratory virus within the genus Enterovirus and family of Picornaviridae. Genetically, it closely related to rhinovirus that replicates in tract causes disease. Since 2014, EV-D68 has been associated with neurologic syndrome acute flaccid myelitis (AFM).In October 2016, questionnaires were sent out European network including 66 virologists clinicians, develop an inventory EV-D68-associated AFM cases Europe. Clinical virologic information case patients was...
Blocking mTORC1 rescues the neural progenitor cell migratory defect caused by depletion of STRADA pseudokinase and reduces seizures in patients with a rare neurodevelopmental disorder.
Developmental Coordination Disorder (DCD) is a neurodevelopmental condition presenting with poor motor skill development and impaired coordination at young age. To diagnose DCD, neurologic conditions explanatory for the phenotype, including structural brain abnormalities like hydrocephalus, must be first ruled out. However, these may phenotypically mimic which can hamper their distinction. In this article, we report patient in whom initial diagnosis of DCD was withdrawn after identification...
Differentiation between acute flaccid myelitis (AFM) and Guillain-Barré syndrome (GBS) can be difficult, particularly in children. Our objective was to improve the diagnostic accuracy by giving recommendations based on a comparison of clinical features criteria children with AFM or GBS.A cohort 26 associated enterovirus D68 compared 156 GBS. The specificity Brighton criteria, used for GBS diagnosis, evaluated Centers Disease Control Prevention (CDC) cohort.Children those had shorter interval...
Objectives To describe the use and outcomes of neurological wake-up test (NWT) in pediatric severe traumatic brain injury (pTBI). Design Retrospective single-center observational cohort study. Setting Medical-surgical tertiary intensive care unit (PICU) a university medical center Level 1 Trauma Center. Patients Children younger than 18 years with TBI [i.e., Glasgow Coma Scale (GCS) ≤8] admitted between January 2010 December 2020. Subjects non-traumatic were excluded. Measurements main...
Elizabethkingia anophelis is a multidrug-resistant pathogen causing high mortality and morbidity in adults with comorbidities neonates. We report Dutch case of E. meningitis neonate, clonally related to samples taken from an automated infant milk dispenser located at the family’s residence. inform about emergence suggest molecular surveillance hospitals other health settings. This first connecting formula invasive infection neonate.
With interest, we have read the article by Olum et al 1 published recently in Brain Communications.In their report, they describe six cases of suspected acute flaccid myelitis (AFM), identified a relatively short time Uganda.They discuss difficulty confirming diagnosis without availability additional investigations and limitations this produces applicability current diagnostic criteria low to middle-income countries (LMIC).Together with infrastructure for adequate surveillance, has...
Acute flaccid myelitis (AFM) and transverse (TM) are serious conditions that may be difficult to differentiate, especially at onset of disease. In this study, we compared clinical features pediatric AFM TM evaluated current diagnostic criteria, aiming improve early accurate diagnosis.Two cohorts children with enterovirus D68-associated clinically diagnosed were regarding presenting features, additional investigations, outcome. Current criteria for applied evaluate their specificity.Children...
It may be difficult for clinicians to estimate the prognosis of pediatric acute transverse myelitis (ATM). The aim this study was define prognostic factors relapsing disease and poor outcome in ATM.This prospective cohort included 49 children, 18 boys 31 girls (median age 13.1 years, IQR 6.5-16.2) with a first episode ATM. Factors associated (Expanded Disability Status Scale (EDSS) ≥ 4) were assessed during median follow-up 37 months (IQR 18-75).In total, 14 patients (29%) experienced 1...
Background/Purpose: Acute flaccid myelitis (AFM) is characterized by acute onset of limb weakness mostly preceded fever or illness in combination with decreased muscle tone, decreased/absent deep tendon reflexes and CSF pleocytosis as well cranial nerve involvement.