A5027302677- Acute Ischemic Stroke Management
- Blood Coagulation and Thrombosis Mechanisms
- Moyamoya disease diagnosis and treatment
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Neonatal and fetal brain pathology
- Intracranial Aneurysms: Treatment and Complications
- Cerebral Venous Sinus Thrombosis
- Cerebrovascular and Carotid Artery Diseases
- Neurological Complications and Syndromes
- Congenital Heart Disease Studies
- Stroke Rehabilitation and Recovery
- Pregnancy and preeclampsia studies
- Renal and Vascular Pathologies
- Vascular Malformations Diagnosis and Treatment
- Cardiovascular and Diving-Related Complications
- Coronary Artery Anomalies
- Retinal and Optic Conditions
- Neonatal Respiratory Health Research
- Herpesvirus Infections and Treatments
- Complement system in diseases
- Vascular anomalies and interventions
- Cerebral Palsy and Movement Disorders
- COVID-19 Clinical Research Studies
- Fetal and Pediatric Neurological Disorders
University of Colorado Denver
2016-2025
Children's Hospital Colorado
2016-2025
Rocky Vista University
2024
University of Colorado Anschutz Medical Campus
2011-2024
Embry–Riddle Aeronautical University
2022-2023
Hospital for Sick Children
2009-2023
Children's Hospital Research Institute of Manitoba
2020
University of Toronto
2020
University of Manitoba
2020
SickKids Foundation
2020
Purpose- Much has transpired since the last scientific statement on pediatric stroke was published 10 years ago. Although long been recognized as an adult health problem causing substantial morbidity and mortality, it is also important cause of acquired brain injury in young patients, occurring most commonly neonate throughout childhood. This represents a synthesis data consensus leading experts childhood cardiovascular disease stroke. Methods- Members writing group were appointed by...
Background— Cerebral arteriopathies, including an idiopathic focal cerebral arteriopathy of childhood (FCA), are common in children with arterial ischemic stroke and strongly predictive recurrence. To better understand these lesions, we measured predictors within a large international series stroke. Methods Results— Between January 2003 July 2007, 30 centers the International Pediatric Stroke Study enrolled 667 (age, 29 days to 19 years) abstracted clinical radiographic data. its subtypes...
Background and Purpose— The implementation of uniform nomenclature classification in adult arterial ischemic stroke (AIS) has been critical for defining outcomes recurrence risks according to etiology developing risk-stratified treatments. In contrast, current childhood AIS are often overlapping or contradictory. Our purpose was develop a comprehensive consensus-based system AIS. Methods— Using modified-Delphi method, members the International Pediatric Stroke Study (IPSS) developed...
Background and Purpose— Stroke is an important cause of death disability among children. Clinical trials for childhood stroke require a valid reliable acute clinical scale. We evaluated interrater reliability (IRR) pediatric adaptation the National Institutes Health Scale. Methods— The Scale was developed by adult experts modifying each item children, retaining all examination items scoring ranges Children 2 to 18 years age with arterial ischemic were enrolled in prospective cohort study...
Background and Purpose— Published cohorts of children with arterial ischemic stroke (AIS) in the 1990s to early 2000s reported 5-year cumulative recurrence rates approaching 20%. Since then, utilization antithrombotic agents for secondary prevention has increased. We sought determine predictors recurrent current era. Methods— The Vascular Effects Infection Pediatric Stroke (VIPS) study enrolled 355 AIS at 37 international centers from 2009 2014 followed them prospectively stroke. Index...
Background and Purpose— Although arteriopathies are the most common cause of childhood arterial ischemic stroke, strongest predictor recurrent they difficult to diagnose. We studied role clinical data follow-up imaging in diagnosing cerebral cervical arteriopathy children with stroke. Methods— Vascular effects infection pediatric an international prospective study, enrolled 355 cases stroke (age, 29 days 18 years) at 39 centers. A neuroradiologist neurologist independently reviewed vascular...
Background and Purpose— In adult stroke, the advent of thrombolytic therapy led to development primary stroke centers capable diagnose treat patients with acute rapidly. We describe pediatric through preparation participating in Thrombolysis Pediatric Stroke (TIPS) trial. Methods— collected data from 17 enrolling TIPS regarding process becoming an center capability diagnose, evaluate, rapidly, including use therapy. Results— Before 2004, <25% sites had continuous 24-hour availability...
<h3>BACKGROUND AND PURPOSE:</h3> Childhood arteriopathies are rare but heterogenous, and difficult to diagnose classify, especially by nonexperts. We quantified clinical imaging characteristics associated with childhood arteriopathy subtypes facilitate their diagnosis classification in research settings. <h3>MATERIALS METHODS:</h3> The Vascular Effects of Infection Pediatric Stroke (VIPS) study prospectively enrolled 355 children arterial ischemic stroke (2010–2014). A central team experts...
Severe complications of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) include arterial ischemic stroke (AIS) in adults and multisystem inflammatory children. Whether is a frequent complication pediatric SARS-CoV-2 unknown. This study aimed to determine the proportion cases with incident strokes first 3 months pandemic an international cohort.We surveyed 61 sites expertise. Survey questions included: numbers hospitalized (≤ 18 years) patients SARS-CoV-2; neonatal childhood...
To characterize predictors of recovery and outcome following pediatric arterial ischemic stroke, hypothesizing that age influences after stroke.We studied children enrolled in the International Pediatric Stroke Study between January 1, 2003 July 31, 2014 with 2-year follow-up stroke. Outcomes were defined at discharge by clinician grading 2 years Outcome Measure. Demographic, clinical, radiologic examined. We changes from to as (improved outcome), emerging deficit (worse or no change.Our...
Lipoprotein (a) is a risk factor for adult cardiovascular events, in which the apolipoprotein component thought to promote atherogenesis and impair fibrinolysis. We investigated whether elevated plasma lipoprotein concentration small predominant isoform size (number of kringle-4 domains) are factors childhood arterial ischemic stroke correlate with fibrinolytic function. Patients who had an (29 days - 90th percentile race-specific reference values
Background and Purpose- Focal cerebral arteriopathy (FCA)-a common cause of arterial ischemic stroke in previously healthy children-often progresses over days to weeks, increasing the risk recurrent stroke. We developed a novel severity scoring system designed quantify FCA progression correlate with clinical outcomes. Methods- The VIPS study (Vascular Effects Infection Pediatric Stroke) prospectively enrolled 355 children (2010-2014), including 41 centrally confirmed FCA. Two...
<h3>Objective</h3> To determine that children with arterial ischemic stroke (AIS) due to an identifiable arteriopathy are distinct from those without and each subtype has unique recognizable clinical features. <h3>Methods</h3> We report a large, observational, multicenter cohort of AIS, age 1 month 18 years, enrolled in the International Pediatric Stroke Study 2003 2014. Clinical demographic differences were compared by use Fisher exact test, linear step-up permutation min-<i>p</i>...
Previous studies have indicated a male predominance in pediatric stroke. To elucidate this gender disparity, total testosterone concentration was measured children with arterial ischemic stroke (AIS; n = 72), cerebral sinovenous thrombosis (CSVT; 52), and 109 healthy controls. Testosterone levels above the 90th percentile for age were documented 10 AIS (13.9%) CSVT (19.2%), totaling 16.7% of patients thromboembolism overall, as compared only 2 controls (1.8%; p 0.002). In multivariate...
Previous studies in adults and mice have implicated ADAMTS13 (a disintegrin metalloproteinase with a thrombospondin type 1 motif, member 13), also known as von Willebrand factor (VWF)-cleaving protease, protective for stroke. Here we investigated 208 pediatric patients arterial ischemic stroke (AIS) 125 population-based control children frequency-matched case-control study.The proportion of patients/controls activity levels below above the 10th percentile was compared. Additionally, quintile...