A5023613805- Respiratory viral infections research
- Influenza Virus Research Studies
- SARS-CoV-2 detection and testing
- Pneumonia and Respiratory Infections
- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Diagnosis and treatment of tuberculosis
- Infectious Diseases and Tuberculosis
- Chronic Disease Management Strategies
- Pneumocystis jirovecii pneumonia detection and treatment
- Viral Infections and Immunology Research
- Infection Control and Ventilation
- Vaccine Coverage and Hesitancy
- Lung Cancer Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Air Quality and Health Impacts
- Nosocomial Infections in ICU
- Viral gastroenteritis research and epidemiology
- Immune Response and Inflammation
- Antimicrobial Resistance in Staphylococcus
- Neurogenetic and Muscular Disorders Research
- Helicobacter pylori-related gastroenterology studies
Imperial College Healthcare NHS Trust
2010-2023
Imperial College London
2012-2023
UK Health Security Agency
2022-2023
NIHR Imperial Biomedical Research Centre
2017-2022
Public Health England
2020-2021
University Hospital Dubrava
2018
University of Douala
2018
Al-Azhar University
2018
Regionshospitalet Viborg
2018
University Hospital Centre Zagreb
2018
Severe acute respiratory syndrome coronavirus 2 viral load in the upper tract peaks around symptom onset and infectious virus persists for 10 days mild-to-moderate disease (n = 324 samples analysed). RT-PCR cycle threshold (Ct) values correlate strongly with cultivable virus. Probability of culturing declines to 8% Ct > 35 6% after onset; it is similar asymptomatic symptomatic persons. Asymptomatic persons represent a source transmissible
Knowledge of the window SARS-CoV-2 infectiousness is crucial in developing policies to curb transmission. Mathematical modelling based on scarce empirical evidence and key assumptions has driven isolation testing policy, but real-world data are needed. We aimed characterise across full course infection a community setting.The Assessment Transmission Contagiousness COVID-19 Contacts (ATACCC) study was UK prospective, longitudinal, cohort contacts newly diagnosed, PCR-confirmed index cases....
Effectively implementing strategies to curb SARS-CoV-2 transmission requires understanding who is contagious and when. Although viral load on upper respiratory swabs has commonly been used infer contagiousness, measuring emissions might be more accurate indicate the chance of onward identify likely routes. We aimed correlate emissions, in tract, symptoms, longitudinally, participants were experimentally infected with SARS-CoV-2.
Obesity has been identified as a risk factor for adverse outcomes of 2009 H1N1 influenza. However, the impact obesity on infection remains controversial. There are limited data investigating effect community-acquired pneumonia (CAP). This prospective observational study included patients presenting with CAP who had body mass index (BMI) measured admission. Outcome measures 30-day mortality and need mechanical ventilation or inotropic support (MV/IS). 1079 were included, 21% classified obese...
Abstract Objectives To investigate the proportion of lateral flow tests (LFTs) that produce negative results in those with a high risk infectiousness from SARS-CoV-2, to impact stage and severity disease, compare predictions made by influential mathematical models findings empirical studies. Design Linked data analysis combining evidence accuracy Innova LFT, probability positive viral culture or transmission secondary cases, distribution loads SARS-CoV-2 individuals different settings....
The pH stability of the hemagglutinin surface protein varies between different influenza strains and subtypes can affect virus’ ability to replicate transmit. Here, we demonstrate a delicate balance that virus strikes within without target cell. We show pH-stable enables human more effectively in airway cells mouse lungs by facilitating survival extracellular environment upper respiratory tract. Conversely, after entering cells, being stable confers relative disadvantage, resulting less...
The transmissibility and pandemic potential of influenza viruses depends on their ability to efficiently replicate be released from an infected host, retain viability as they pass through the environment, then initiate infection in next host. There is a significant gap knowledge about viral properties that enable survival between hosts, due lack experimental methods reliably isolate viable virus air. Using novel technique, we characterise infectious droplets emitted by 2009 H1N1-infected...
Enteroviruses are a common cause of seasonal childhood infections. The vast majority enterovirus infections mild and self-limiting, although neonates can sometimes develop severe disease. Myocarditis is rare complication infection. Between June 2022 April 2023, twenty cases neonatal enteroviral myocarditis caused by coxsackie B viruses were reported in the United Kingdom. Sixteen required critical care support two died. Enterovirus PCR on whole blood was most sensitive diagnostic test. We...
Abstract Increasing detections of vaccine-derived poliovirus (VDPV) globally, including in countries previously declared polio free, is a public health emergency international concern. Individuals with primary immunodeficiency (PID) can excrete polioviruses for prolonged periods, which could act as source cryptic transmission viruses potential to cause neurological disease. Here, we report on the detection immunodeficiency-associated VDPVs (iVDPV) from two asymptomatic male PID children UK...
Folate deficiency is an uncommon cause of pyrexia. We describe the case a 29-year-old male who presented with pyrexial illness subsequently attributed to megaloblastic anaemia secondary severe folate deficiency, after exclusion other infective or inflammatory causes. A temperature chart documenting course patient's pyrexia and potential pathophysiological mechanisms are proposed. reversible that should be considered in any patient presents unknown cause.
<h3>Introduction and Objectives</h3> Cardiac arrhythmias are regularly found in patients with COPD, higher frequencies reported during exacerbations. We wished to examine the impact of tachycardia new onset atrial fibrillation (AF) on long term outcome hospitalised a COPD exacerbation. <h3>Methods</h3> A prospective observational cohort study admitted an acute exacerbation (AECOPD) was performed. Patients were >40 years age, spirometry confirmed one 12 UK centres between 2009–2012. Hazard...
Introduction London has a high rate of tuberculosis (TB) with 2572 cases reported in 2014. Cases are more common non-UK born, alcohol-dependent or homeless patients. The emergency department (ED) presents an opportunity for the diagnosis TB these patient groups. This is first study describing clinico-radiological characteristics such attendances two urban UK hospitals pulmonary (PTB) and extrapulmonary (EPTB). Methods We conducted retrospective cohort using Register (LTBR) hospital records...
Background: The SARS-CoV-2 Delta variant is highly transmissible and spreading globally but a detailed understanding of community transmission risks in vaccinated populations lacking.Methods: Between September 2020 August 2021, we recruited 510 contacts 422 UK COVID-19 cases to cohort study. A total 7194 upper respiratory tract (URT) samples were tested from sequential daily sampling participants for up 20 days. We analysed risk by vaccination status 139 exposed the variant. compared viral...
The success of case isolation and contact tracing for the control severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission depends on accuracy speed identification. We assessed whether inclusion additional symptoms alongside three canonical (CS),
Abstract Background Postmortem testing can improve our understanding of the impact severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) if sufficiently sensitive and specific. Methods We investigated postmortem sensitivity specificity reverse transcriptase polymerase chain reaction (PCR) on upper swabs using a dataset everyone tested for SARS-CoV-2 before after death in England, 1 March to 29 October 2020. analyzed those with positive test by time test. developed multivariate model...
Background: Effectively implementing strategies to curb SARS-CoV-2 transmission requires understanding who is contagious and when. Whilst viral load (VL) on upper respiratory swabs has commonly been used infer contagiousness, measuring emissions may be more accurate indicate the chance of onward identify likely routes. human challenge involves intentional inoculation volunteers with a standardised dose route same virus, providing opportunities sample intensely across whole course infection...
### Learning point for clinicians Severe eosinophilic dermatitis with systemic symptoms is rare. We report, the first time, that clinical and high CRP (123 mg/l) were due to an IL-6 IL-8 cytokine storm. Systemic disease control was only achieved dose oral prednisolone, topical triamcinolone affected skin dapsone. A 27-year-old woman presented a 12-day history of worsening fever rash. Erythematous, indurated pruritic lesions had been developing on her inner thighs. They went spread arms...