A5035296750- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Eosinophilic Esophagitis
- Pediatric health and respiratory diseases
- Infant Health and Development
- Respiratory viral infections research
- Urticaria and Related Conditions
- Cell Image Analysis Techniques
- Influenza Virus Research Studies
- Digital Imaging for Blood Diseases
- Gut microbiota and health
- Drug-Induced Adverse Reactions
- Electrolyte and hormonal disorders
- Bacterial Infections and Vaccines
- Occupational exposure and asthma
- Vitamin D Research Studies
- Probiotics and Fermented Foods
- Child Nutrition and Feeding Issues
- Dermatology and Skin Diseases
- Single-cell and spatial transcriptomics
- Pneumonia and Respiratory Infections
- SARS-CoV-2 and COVID-19 Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Eosinophilic Disorders and Syndromes
Great North Children's Hospital
2016-2025
Royal Victoria Infirmary
2013-2024
Newcastle upon Tyne Hospitals NHS Foundation Trust
2019-2024
Newcastle University
2017-2022
Scotland and Northern Ireland Forum for Environmental Research
2019
St Mary's Hospital
2019
St. Mary's Hospital
2019
NIHR Southampton Respiratory Biomedical Research Unit
2012-2015
University Hospital Southampton NHS Foundation Trust
2003-2015
University of Southampton
2011-2013
Abstract Anaphylaxis is a clinical emergency which all healthcare professionals need to be able recognize and manage. The European Academy of Allergy Clinical Immunology multidisciplinary Task Force has updated the 2014 guideline. guideline was developed using AGREE II framework GRADE approach. evidence systematically reviewed recommendations were created by weighing up benefits harms. peer‐reviewed external experts in public consultation. use criteria identify anaphylaxis suggested with...
Imaging flow cytometry (IFC) produces up to 12 spectrally distinct, information-rich images of single cells at a throughput 5,000 per second. Yet often, cell populations are still studied using manual gating, technique that has several drawbacks, hence it would be advantageous replace gating with an automated process. Ideally, this process based on stain-free measurements, as the currently used staining techniques expensive and potentially confounding. These measurements originate from...
Prebiotics and probiotics (synbiotics) can modify gut microbiota have potential in allergy management when combined with amino-acid-based formula (AAF) for infants cow's milk (CMA). This multicenter, double-blind, randomized controlled trial investigated the effects of an AAF-including synbiotic blend on percentages bifidobacteria Eubacterium rectale/Clostridium coccoides group (ER/CC) feces from suspected non-IgE-mediated CMA. Feces age-matched healthy breastfed were used as reference...
Background Food protein induced gastrointestinal allergies are difficult to characterise due the delayed nature of this allergy and absence simple diagnostic tests. Diagnosis is based on an focused history which can be challenging often yields ambiguous results. We therefore set out describe a group children with type allergy, provide overview typical profile, symptoms management strategies.Methods This retrospective analysis was performed at Great Ormond Street Children’s Hospital. Medical...
Previous studies provide evidence for an association between modifications of the gut microbiota in early life and development food allergies. We studied faecal composition (16S rRNA gene amplicon sequencing) microbiome functionality (metaproteomics) a cohort 40 infants diagnosed with cow's milk allergy (CMA) when entering study. Some showed outgrowth CMA after 12 months, while others did not. Faecal was analysed directly diagnosis (baseline) as well 6 months The aim to gain insight on...
Here we report follow-up data from a double-blind, randomized, controlled multicenter trial, which investigated fecal microbiota changes with new amino acid-based formula (AAF) including synbiotics in infants non-immunoglobulin E (IgE)-mediated cow's milk allergy (CMA). Subjects were randomized to receive test product (AAF fructo-oligosaccharides and Bifidobacterium breve M-16V) or control for 8 weeks, after could continue study until 26 weeks. Fecal percentages of bifidobacteria Eubacterium...
Altered gut microbiota is implicated in cow's milk allergy (CMA) and differs markedly from healthy, breastfed infants. Infants who suffer severe CMA often rely on protein avoidance and, when breastfeeding not possible, specialised infant formulas such as amino-acid based (AAF). Herein, we report the effects of an AAF including specific synbiotics oral gastrointestinal infants with non-IgE mediated reference to
There is an unmet need for specialist allergy treatment in the United Kingdom. Allergen immunotherapy and with omalizumab chronic spontaneous urticaria (CSU) are key markers these services. The British Society Allergy Clinical Immunology (BSACI) Registry Immunotherapy (BRIT) a national project to record real-world effectiveness, safety access aero-allergen, venom peanut as well CSU. We described participant demographics, index of multiple deprivation (IMD) from registry launch. Data 1835...
Background. We investigated antibody persistence in children 1 year after 2 doses of either an AS03B-adjuvanted split-virion or nonadjuvanted whole-virion monovalent pandemic influenza vaccine and assessed the immunogenicity reactogenicity a subsequent dose trivalent (TIV).
Live attenuated influenza vaccine (LAIV) is recommended for annual vaccination in children from age 2 years. However, some guidelines recommend against its use with asthma or recurrent wheeze due to concerns over potential induce wheezing.
Abstract Allergic diseases are on the increase and can affect child’s well-being. The aim of this survey was to assess regional schools’ preparedness in dealing with anaphylaxis following publication national international guidelines for schools 2014. developed 2015 distributed Cumbria, North West England, UK between 2016. Only 47% respondents (95% CI, 39–57%) felt confident manage anaphylaxis. Schools without allergic pupils were significantly less likely have a standard management protocol...
Background Food protein-induced enterocolitis syndrome (FPIES) is a delayed type of food allergy, most often seen in infancy. We aimed to estimate its incidence, describe common triggers and the patient journeys this rare but serious condition. Design undertook prospective epidemiological survey FPIES using British Paediatric Surveillance Unit. Setting UK Ireland. Participants A all paediatricians over 13 months between January 2019 February 2020. Main outcome measures 204 cases were...
Iodine-deficient goitre was common in some parts of the UK prior to introduction salt iodisation. Many contemporary preparations do not contain much iodine, and there are renewed concerns about iodine status population. We present a boy with severe allergy who developed significant thyroid dysfunction association an iodine-deficient ‘food-restricted’ diet. The case highlights importance comprehensive nutritional assessment all children on multiple food restrictions.
To test for immunologic noninferiority of antibody responses to Hib and MenC using a 6-in-1 combination vaccine (DTPa-IPV/Hib-MenC-TT) compared with DTPa-IPV-Hib plus MenC-CRM197, before after 12-month Hib-MenC-TT booster.Pragmatic open-label, randomized, multicenter, UK study. "6-in-1" group received DTPa-IPV/Hib-MenC-TT at 2, 3 4 months; control months MenC-CRM197 months. Both groups 12 Concomitant vaccines: pneumococcal conjugate 13 months, measles, mumps rubella months.One hundred...
WORKSHOP 4: Challenging clinical scenarios (CS01–CS06) CS01 Bullous lesions in two children: solitary mastocytoma S. Tolga Yavuz, Ozan Koc, Ali Gungor, Faysal Gok CS02 Multi-System Allergy (MSA) of cystic fibrosis: our institutional experience Jessica Hawley, Christopher O’Brien, Matthew Thomas, Malcolm Brodlie, Louise Michaelis CS03 Cold urticaria pediatric age: an invisible cause for severe reactions Inês Mota, Ângela Gaspar, Susana Piedade, Graça Sampaio, José Geraldo Dias, Miguel Paiva,...