A5049688747- Asthma and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Allergic Rhinitis and Sensitization
- MicroRNA in disease regulation
- Respiratory and Cough-Related Research
- Drug-Induced Adverse Reactions
- Urticaria and Related Conditions
- Nutrition and Health Studies
- Immune Cell Function and Interaction
- Marketing and Advertising Strategies
- Cancer-related molecular mechanisms research
- Cytomegalovirus and herpesvirus research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pediatric health and respiratory diseases
- Contact Dermatitis and Allergies
- Gut microbiota and health
- Respiratory viral infections research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immune Response and Inflammation
- Inhalation and Respiratory Drug Delivery
- Sinusitis and nasal conditions
- Dermatology and Skin Diseases
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
Medical University of Lodz
2016-2025
NSAID-exacerbated respiratory disease (N-ERD) is a chronic eosinophilic, inflammatory disorder of the tract occurring in patients with asthma and/or rhinosinusitis nasal polyps (CRSwNP), symptoms which are exacerbated by NSAIDs, including aspirin. Despite some progress understanding pathophysiology syndrome, affects 1/10 and rhinosinusitis, it remains diagnostic therapeutic challenge. In order to provide evidence-based recommendations for diagnosis management N-ERD, panel international...
Aim The incidence of concomitant conditions increases with age. In elderly patients, the presence comorbidities has been related to course and severity asthma. aim present study was assess impact treatment on asthma control in older adults. Methods A total 93 (age >65 years) 78 younger 30–50 asthmatic patients were randomly selected from a database including 1755 asthmatics. Evaluation consisted questionnaire, spirometry skin prick testing. Results I n asthmatics, higher chronic (mean 8.4...
Non-steroidal anti-inflammatory drug-exacerbated respiratory disease (N-ERD) is a phenotype of bronchial asthma that characterized by severe course and the presence chronic rhinosinusitis (CRS) with nasal polyps. MicroRNAs (miRNAs) belong to family small, non-coding RNAs whose primary function regulate gene transcription. The aim this study was determine miRNA profile validate selected miRNAs in biological material from upper tract collected minimally-invasive method patients N-ERD. assessed...
Purpose: Periostin is considered a biomarker for eosinophilic airway inflammation and have been associated with NSAID-Exacerbated Respiratory Disease (NERD) chronic rhinosinusitis (CRS).In this study, we aimed to evaluate periostin in exhaled breath condensate (EBC) serum of patients various asthma phenotypes.Methods: The study included 40 asthmatic (22 NERD) 17 healthy controls.All the procedures (questionnaire, spirometry, FeNO, nasal swabs, EBC collecting, blood sampling) were performed...
IIn nt tr ro od du uc ct ti io on n: : Polymorphisms within innate immunity genes are associated with allergic phenotypes but results variable.These associations were not analyzed respect to allergen exposure.We investigated of TLR and CD14 polymorphisms allergy in the context house dust mite (HDM) exposure.M Ma at te er ri ia al l a an nd d m me et th ho ds s: Children, aged 12-16 years (n = 326), recruited from downtown rural locations assessed by allergist.Skin prick tests, total...
Immunological mechanisms underlying asthma exacerbation have not been elucidated. The aim of this study was to assess the associations various traits with selected serum microRNA (miRNA) expression and T-cell subpopulations.Twenty-one asthmatics were studied during (exacerbation visit [EV] follow-up [FV] at 6 weeks). At both visits, spirometry performed, fractional exhaled nitric oxide (FeNO) measured, nasopharyngeal blood samples collected. In samples, respiratory viruses assayed by...
Abstract Background The course of asthma may differ between elderly asthmatics (EA) and non-elderly (nEA), which be partially associated with an age-dependent aberrant immune response. aim the study was to determine influence serum miRNA expression on characteristics systemic inflammation markers in EA nEA. Methods Control severity asthma, pulmonary function FeNO were assessed 28 31 nEA patients. control group included 59 healthy individuals. selected miRNAs measured rt-PCR, proinflammatory...
Cytomegalovirus (CMV) IgG antibodies have been associated with inflammaging and immunosenescence. We aimed to assess the presence of CMV DNA in blood adult elderly patients bronchial asthma establish potential association DNAemia characteristics. Eighty-five asthmatics, 74 younger patients, 114 age-matched controls were recruited. The was detected using commercial artus assay 10.7% but negative all control individuals. secondary identified 41.5% asthmatics 13.3% subjects (P < .001). Presence...
The aim of the study was to evaluate relationship between house dust mite, cat and dog allergen levels with household characteristics in houses children living urban rural areas central Poland.Dust samples were collected from 141 191 houses. Der f1 + p1, Can f 1, Fel d1 measured associated residential conditions atopy-related health outcomes assessed by clinical examination skin prick testing.Concentrations mite allergens lower, higher depended on presence a respective animal house. In...
Lambda interferons (IFNLs) have immunomodulatory functions at epithelial barrier surfaces. IFN-λ4, a recent member of this family is expressed only in subset the population due to frameshift-causing DNA polymorphism rs368234815. We examined association with atopy (aeroallergen sensitization) and asthma Polish hospital-based case-control cohort comprising well-characterized adult asthmatics (n = 326) healthy controls 111). In combined cohort, we saw no and/or atopy. However, IFN-λ4-generating...
Periostin is a matricellular protein expressed by many tissues. Its release may be enhanced, among others, through mechanical stimulation of muscles and bones as well cytokines allergic inflammation.Our aim was to assess periostin levels in serum exhaled breath condensate (EBC) professional athletes, asthmatics healthy controls. We also sought determine whether acute treadmill exercise influences EBC periostin.Study groups included 9 competitive swimmers, 10 mild-to-moderate 7 Athletes were...
microRNAs are short, noncoding RNA molecules involved in many inflammatory processes including bronchial asthma. Rhinoviruses the main cause of acute asthma attack and may be miRNA profile dysregulation. The aim study was to investigate serum during exacerbation middle-aged elderly patients. We also evaluated this group vitro response rhinovirus 1b exposure. Seventeen asthmatics were admitted an outpatient clinic within a period 6-8 weeks later. Blood samples collected from subjects PBMCs...
AMA Bochenek G, Chełmińska M, Gluck J, Nittner-Marszalska Porębski Wardzyńska A. Safety of performing selected allergological procedures in drug hypersensitivity. Position the Drug Hypersensitivity Section Polish Society Allergology. Alergologia Polska - Journal 2023;10(3):152-166. doi:10.5114/pja.2023.131704. APA Bochenek, G., Chełmińska, M., Gluck, J., Nittner-Marszalska, Porębski, & Wardzyńska, (2023). Allergology, 10(3), 152-166. https://doi.org/10.5114/pja.2023.131704 Chicago Grażyna,...
Drug hypersensitivity reaction (DHR) is a common reason for an allergology con- sultation, during which it not only necessary to gather thorough medical history, but also propose and perform diagnostic tests.The aim of the study was retrospectively assess patients with profile preliminary drug diagnosis, usefulness NSAID classifica- tion in outpatient practice, analyze results skin, provocation, tolerance tests performed Immunology Allergy Clinic patients.Around 501 records referred academic...
<h3>Background</h3> Osteoporosis and osteoporotic fractures are among the major problems of elderly population. Although deaths related to bone disease usually have indirect causes it is assessed that approximately 20% patients dies due complications within first year after hip fracture another 30% need permanent care. Some risk factors can be modified by lifestyle (diet, habits, exercise) intervention. To introduce this modifications people aware burden, preventive measures osteoporosis....
This article was originally published online on 8 April 2015 Aging is associated with structural and functional changes in the immune system which may be responsible for a higher incidence of infection elderly. The aim study to assess prevalence infections among elderly students Academy Healthy Ageing establish factors frequent infections. questionnaire including questions about infections, medication, comorbidities socio-economic background filled by 157 (83% women 17% men, mean age 68.2)...