A5034812453- Asthma and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Hearing, Cochlea, Tinnitus, Genetics
- Respiratory viral infections research
- Acute Ischemic Stroke Management
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- Multiple Sclerosis Research Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Noise Effects and Management
- Pediatric health and respiratory diseases
- Ion Channels and Receptors
- Cytomegalovirus and herpesvirus research
- Vestibular and auditory disorders
- Blood properties and coagulation
- Cancer-related molecular mechanisms research
- Atherosclerosis and Cardiovascular Diseases
- Ion channel regulation and function
- Parkinson's Disease Mechanisms and Treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Lipoproteins and Cardiovascular Health
- Exercise and Physiological Responses
- Respiratory and Cough-Related Research
- Cerebrovascular and genetic disorders
- Tracheal and airway disorders
Medical University of Lodz
2015-2024
Wojskowy Instytut Medycyny Lotniczej
2019
Centralny Szpital Kliniczny
2018
McMaster University
2018
ENT and Allergy
2018
Nofer Institute of Occupational Medicine
2007-2014
Uniwersytecki Szpital Kliniczny w Opolu
2012
Górnośląskie Centrum Medyczne
1999
Noise-induced hearing loss (NIHL) is an important occupational hazard that results from interaction between genetic and environmental factors. Although the risk factors have been studied quite extensively, little known about On basis of multiple studies, it was proposed oxidative stress plays role in development NIHL. Here, we investigated whether variations (single nucleotide polymorphisms; SNPs) catalase gene (CAT), one genes involved stress, influence noise susceptibility. Audiometric...
Millions of people are daily exposed to high levels noise. Consequently, noise-induced hearing loss (NIHL) is one the most important occupational health hazards worldwide. In this study, we performed an association study for NIHL based on a candidate gene approach. 644 Single Nucleotide Polymorphisms (SNPs) in 53 genes were analyzed two independent sample sets, Swedish set and part Polish set. Eight SNPs with promising results selected analysed remaining samples. One SNP PCDH15 (rs7095441),...
Summary Noise‐induced hearing loss (NIHL) is one of the leading occupational health risks in industrialized countries. It results from an interaction between environmental and genetic factors, however nature factors contributing to NIHL has not yet been clarified. Here, we investigated whether variations 10 genes putatively involved potassium recycling pathway inner ear may influence susceptibility noise. 99 SNPs were genotyped Polish noise‐exposed workers, categorized into susceptible...
Noise-induced hearing loss (NIHL) is a complex disease resulting from the interaction between external and intrinsic/genetic factors. Based on mice studies, one of most interesting candidate gene for NIHL susceptibility CDH23-encoding cadherin 23, component stereocilia tip links. The aim this study was to analyze selected CDH23 single nucleotide polymorphisms (SNPs) evaluate their with environmental individual factors in respect humans.A group consisted 314 worst-hearing 313 best-hearing...
Introduction. The aim of this study was to report the course and outcome SARS-CoV-2 infection in multiple sclerosis (MS) patients treated with disease-modifying therapies (DMTs) Poland. A major concern for neurologists worldwide is MS different DMTs. Although initial studies do not suggest an unfavourable group patients, data limited. Materials methods. This included 396 DMTs confirmed from 28 Polish centres. Information concerning patient demographics, comorbidities, clinical MS, current...
Introduction: Low-density lipoprotein cholesterol (LDL-C) has been reported to increase platelet activation.Reducing the level of LDL-C with statins induces important pleiotropic effects such as inhibition.This association between activity and statin therapy may be clinically in reducing risk ischemic stroke.We investigated effect simvastatin on activation markers (platelet CD62P, sP-selectin, platelet-derived microparticles (PDMPs)) hyperlipidemic patients after stroke.Material methods: The...
The aim of this study was to assess the immune response parainfluenza virus type 3 (PIV3), rhinovirus 1B (RV1B) and intracellular Toll-like receptors (TLR) agonists in nasal epithelial cells (NECs) from patients with allergic rhinitis healthy controls. NECs were obtained eight (AR) 11 non-atopic controls (HC) by scraping, grown confluence exposed PIV3, RV1B infection or TLR-3 TLR-7/8 agonists. Interferon (IFN)-λ1, IFN-α, IFN-β regulated on activation, normal T expressed secreted (RANTES)...
Plasma from patients with Parkinson's disease (PD) is a valuable source of information indicating altered metabolites associated the risk or progression disease. Neurotoxicity dopaminergic neurons, which triggered by aggregation α-synuclein, main pathogenic feature PD. However, growing body scientific reports indicates that metabolic changes may precede and directly contribute to neurodegeneration. Identification characterization abnormal pattern in patients' plasma are therefore crucial for...
The common GJB2 (Connexin 26) 35delG mutation might contribute to the development of age-related hearing impairment (ARHI) and noise-induced loss (NIHL).GJB2, a gene encoding gap junction protein expressed in inner ear, has been suggested be involved potassium recycling pathway cochlea. mutations account for large number individuals with nonsyndromic recessive loss, being most frequent populations European origin. Other genes homeostasis have associated ARHI NIHL, distortion product...
Noise exposure causes an excessive reactive oxygen species (ROS) generation as unwanted byproduct of high metabolic activity. Oxidative stress and antioxidative protective mechanisms have been therefore proposed the most interesting issues in development noise-induced hearing loss. The aim this study was to examine changes superoxide dismutase (SOD), catalase (CAT) auditory brainstem response (ABR) cochlea C57BL/6 mice 1, 7 14 days after 4 kHz octave band noise at intensity 110 dB SPL for 8...
In order to gain an insight into determinants of reported variability in immune responses respiratory viruses human bronchial epithelial cells (HBECs) from asthmatics, the HBEC viral infections were evaluated HBECs phenotypically heterogeneous groups asthmatics and healthy controls. obtained during bronchoscopy 10 patients with asthma (6 atopic 4 non-atopic) controls (n=9) grown as undifferentiated cultures. infected parainfluenza virus (PIV)-3 (MOI 0.1) rhinovirus (RV)-1B 0.1), or treated...
Tinnitus is defined as a perception of sound in the absence an external acoustic stimulus. Several factors are known to influence tinnitus, e.g. hearing loss, noise exposure, age, and hypertension. As only certain individuals develop tinnitus presence above risks approximately 50% cases not attributed any particular cause, question arose whether this inter-individual susceptibility could be explained by genetic factors.To test hypothesis that variability genes potassium recycling pathway...
Purpose: Periostin is considered a biomarker for eosinophilic airway inflammation and have been associated with NSAID-Exacerbated Respiratory Disease (NERD) chronic rhinosinusitis (CRS).In this study, we aimed to evaluate periostin in exhaled breath condensate (EBC) serum of patients various asthma phenotypes.Methods: The study included 40 asthmatic (22 NERD) 17 healthy controls.All the procedures (questionnaire, spirometry, FeNO, nasal swabs, EBC collecting, blood sampling) were performed...
Platelet activation plays a key role in the pathogenesis of ischemic cerebrovascular diseases. Thus, it is very important to identify novel pharmacological targets for platelet inhibition improve stroke treatment. The aim study was assess relationship between metabolic disorders and activity markers patients with acute stroke.Ninety-four were divided into four groups with: normolipidemia normoglycemia (NL/NG), n = 25; hyperglycemia (NL/HG), 21; hyperlipidemia (HL/NG), 27; 21. Twenty-one...
Abstract Single nucleotide polymorphisms (SNPs) are the most frequent type of variation in human genome and may underlie differential susceptibility to common genetic diseases. A candidate gene for noise‐induced hearing loss (NIHL) is Cadherin 23 ( CDH23 ). This study aimed analyze a group 10 individuals derived from cohort 949 workers exposed noise, consisted five persons each resistant susceptible extremes. DNA samples were collected coding exons sequenced. We identified total 35 SNPs: 11...
Immunological mechanisms underlying asthma exacerbation have not been elucidated. The aim of this study was to assess the associations various traits with selected serum microRNA (miRNA) expression and T-cell subpopulations.Twenty-one asthmatics were studied during (exacerbation visit [EV] follow-up [FV] at 6 weeks). At both visits, spirometry performed, fractional exhaled nitric oxide (FeNO) measured, nasopharyngeal blood samples collected. In samples, respiratory viruses assayed by...
<i>Background:</i> To investigate the relationship between hyperlipidemia and platelet activation markers – soluble P-selectin (sP-selectin), platelet-derived microparticles (PDMPs) in patients after ischemic stroke. <i>Meth</i><i>ods:</i> 41 stroke (>3 months) confirmed by CT were divided into 2 groups: with (HL, n = 21) normolipidemia (NL, 20). Twenty healthy subjects served as controls. CD62P-positive platelets PDMPs whole blood analyzed use of a...
Abstract Background The course of asthma may differ between elderly asthmatics (EA) and non-elderly (nEA), which be partially associated with an age-dependent aberrant immune response. aim the study was to determine influence serum miRNA expression on characteristics systemic inflammation markers in EA nEA. Methods Control severity asthma, pulmonary function FeNO were assessed 28 31 nEA patients. control group included 59 healthy individuals. selected miRNAs measured rt-PCR, proinflammatory...
Cytomegalovirus (CMV) IgG antibodies have been associated with inflammaging and immunosenescence. We aimed to assess the presence of CMV DNA in blood adult elderly patients bronchial asthma establish potential association DNAemia characteristics. Eighty-five asthmatics, 74 younger patients, 114 age-matched controls were recruited. The was detected using commercial artus assay 10.7% but negative all control individuals. secondary identified 41.5% asthmatics 13.3% subjects (P < .001). Presence...
Impaired regeneration of airway epithelium may lead to persistence inflammation and remodelling. Regeneration injured is a complex phenomenon the role toll-like receptors (TLRs) in stimulation respiratory virus products this process has not been established. This study was undertaken test hypothesis that wound repair modulated by microbial via receptors. Injured not-injured bronchial epithelial cells (ECs) (BEAS-2B line) were incubated with TLR agonists poly(I:C), lipopolisacharide (LPS),...