A5103205403- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Cardiovascular Health and Disease Prevention
- Bone Tumor Diagnosis and Treatments
- Statistical Methods in Epidemiology
- Knee injuries and reconstruction techniques
- Cerebral Venous Sinus Thrombosis
- Orthopedic Surgery and Rehabilitation
- Intracranial Aneurysms: Treatment and Complications
- Reliability and Agreement in Measurement
- Advanced X-ray and CT Imaging
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging and Pathology Studies
- Cardiac Imaging and Diagnostics
- Cancer, Lipids, and Metabolism
- Oral and Maxillofacial Pathology
- Atherosclerosis and Cardiovascular Diseases
- Protease and Inhibitor Mechanisms
- Medical Imaging Techniques and Applications
Hospital de Sant Pau
2022
Health Research Board
2021-2022
University College Dublin
2017-2021
Mater Misericordiae University Hospital
2019
Background and Purpose- Plaque inflammation contributes to stroke coronary events. 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) identifies plaque inflammation-related metabolism. Almost no prospective data exist on the relationship of carotid 18F-FDG uptake early recurrent stroke. Methods- We did a multicenter cohort study BIOVASC (Biomarkers/Imaging Vulnerable Atherosclerosis in Symptomatic Carotid disease) patients with stenosis recent stroke/transient ischemic attack...
Background and Purpose- In randomized trials of symptomatic carotid endarterectomy, only modest benefit occurred in patients with moderate stenosis important subgroups experienced no benefit. Carotid plaque 18F-fluorodeoxyglucose uptake on positron emission tomography, reflecting inflammation, independently predicts recurrent stroke. We investigated if a risk score combining would improve the identification early Methods- derived prospective cohort study recent (<30 days) non-severe...
<h3>Background and Objectives</h3> To determine whether carotid plaque inflammation identified by <sup>18</sup>F-fluorodeoxyglucose (<sup>18</sup>FDG)-PET is associated with late (5-year) recurrent stroke. <h3>Methods</h3> We did an individual-participant data pooled analysis of 3 prospective studies near-identical study methods. Eligible patients had recent nonsevere (modified Rankin Scale score ≤3) ischemic stroke/TIA ipsilateral stenosis (50%–99%). Participants underwent...
In pooled analyses of endarterectomy trials for symptomatic carotid stenosis, several subgroups experienced no net benefit from revascularization. The validated atheroma inflammation lumen-stenosis (SCAIL) score includes stenosis severity and measured by PET improves the identification patients with recurrent stroke compared alone. We investigated whether SCAIL in uncertain revascularization trials.We did an individual-participant data analysis 3 prospective cohort studies (Dublin Carotid...
Positron emission tomography–computed tomography (PET-CT) carotid standardised uptake values (SUV) of 18F-fluorodeoxyglucose (18FDG) have been proposed as an inflammatory biomarker for determining cerebrovascular diseases such stroke. Consideration varying methodological approaches and software packages is critical to the calculation accurate SUVs in cross-sectional longitudinal patient studies. The aim this study was investigate whether or not atherosclerotic plaque are consistent...
Purpose: Pathologic studies suggest that unstable plaque morphology and inflammation are associated with cerebrovascular events. 18 F-fluorodeoxyglucose positron emission tomography ( FDG-PET) is a validated technique for non-invasive imaging of inflammation-related metabolism, MRI can identify morphologic features instability. The aim this study was to investigate the association selected characteristics vulnerability measured PET in patients symptomatic carotid stenosis. Methods: Patients...
Inflammation is important in stroke. Anti-inflammatory therapy reduces vascular events coronary patients. 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) identifies plaque inflammation-related metabolism. However, long-term prospective cohort studies investigating the association between carotid inflammation, identified on 18F-FDG PET and risk of recurrent events, have not yet been undertaken patients with The Biomarkers Imaging Vulnerable Atherosclerosis Symptomatic...