A5005301991- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Spatial Neglect and Hemispheric Dysfunction
- Intracerebral and Subarachnoid Hemorrhage Research
- Atherosclerosis and Cardiovascular Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Hospital Admissions and Outcomes
- Cerebral Venous Sinus Thrombosis
- Emergency and Acute Care Studies
- Dementia and Cognitive Impairment Research
- S100 Proteins and Annexins
- Parkinson's Disease and Spinal Disorders
- Death, Funerary Practices, and Mourning
- Pituitary Gland Disorders and Treatments
- Hip and Femur Fractures
- Healthcare Systems and Practices
- Trauma and Emergency Care Studies
- Ophthalmology and Eye Disorders
- Botulinum Toxin and Related Neurological Disorders
- Neurological Disorders and Treatments
St. Vincent's University Hospital
2016-2025
Health Research Board
2019-2025
Mater Misericordiae University Hospital
2024-2025
University College Cork
2024
Cork University Hospital
2024
National University of Ireland
2022-2024
University College Dublin
2019-2023
National Audit Office
2023
Campbell Collaboration
2021
Collaborative Group (United States)
2021
Marked impairments in and fluctuation of attention are characteristic dementia with Lewy bodies (DLB). The comparative impairment these cognitive domains PD (PD dementia) has not been studied, is important to the conceptual understanding parkinsonian dementias.Detailed evaluations fluctuating (Cognitive Drug Research computerized battery) were undertaken 278 subjects (50 DLB, 48 dementia, 50 PD, 80 AD, elderly controls) from Newcastle register Stavanger (controls, patients recruited both...
Recent randomised trials showed benefit for anti-inflammatory therapies in coronary disease but excluded stroke. The prognostic value of blood inflammatory markers after stroke is uncertain and guidelines do not recommend their routine measurement risk stratification.
<h3>OBJECTIVES</h3> To describe the natural recovery of visuospatial neglect in stroke patients and distribution errors made on cancellation tests using a standardised neuropsychological test battery. <h3>METHOD</h3> A prospective study acute (< seven days) with right hemispheric stroke. Patients identified were followed up for three months monthly clinical testing <h3>RESULTS</h3> There 66 assessed whom 27 (40.9%) had evidence neglect. neglect, admission, mean behavioural inattention...
Inflammation driven by pro-inflammatory cytokines is a new therapeutic target in coronary disease. Few data exist on the association of key upstream and post-stroke recurrence. In prospective cohort study, we investigated between pivotal cytokines, high-sensitivity C-reactive protein (hsCRP) one-year outcomes.BIO-STROKETIA multi-center study non-severe ischemic stroke (modified Rankin score ≤ 3) transient attack. Controls were patients with symptoms attending attack clinics non-ischemic...
<h3>Background and Objectives</h3> To determine whether carotid plaque inflammation identified by <sup>18</sup>F-fluorodeoxyglucose (<sup>18</sup>FDG)-PET is associated with late (5-year) recurrent stroke. <h3>Methods</h3> We did an individual-participant data pooled analysis of 3 prospective studies near-identical study methods. Eligible patients had recent nonsevere (modified Rankin Scale score ≤3) ischemic stroke/TIA ipsilateral stenosis (50%–99%). Participants underwent...
Introduction: Internationally about 3% of people ?65 years live in Long Term Care (LTC). We examined the characteristics and outcomes admitted from LTC with stroke nationally how this changed over COVID19 pandemic. Methods: Data Irish National Audit Stroke 2019-2023 were analysed by source admission. An age, sex subtype matched control group was derived patients home. Pre-stroke discharge modified Rankin Disability Scores (mRS) analysed. Results: Of 25451 admissions, 891 (3.5%) came 22393...
Importance Atrial fibrillation (AF) is a leading cause of stroke, and oral anticoagulants (OAC) reduce this risk. However, there are limited data on the residual risk recurrent stroke in patients with AF. Objective To determine AF by performing systematic review meta-analysis. Data Sources Eligible studies were identified searching Ovid MEDLINE Embase from inception (Ovid: January 1946; Embase: 1970) until 2025. Study Selection enrolled prior ischemic AF, reported information incidence had...
Visuo-spatial neglect (VSN) after stroke is associated with a poor prognosis for rehabilitation. The co-existence of visual field deficit (VFD) VSN may be impaired visuo-spatial functioning and thereby functional outcome.To determine whether the presence VFD (i) exacerbates (ii) influences recovery VSN.A prospective study consecutive acute (<7 days), right-hemisphere patients who were able to undergo detailed assessment fields. Clinical standardized neuropsychological test was administered...
The spatial character of our reaching movements is extremely sensitive to potential obstacles in the workspace. We recently found that this sensitivity was retained by most patients with left visual neglect when between two objects, despite fact they tended ignore leftward object asked bisect space them. This raises possibility obstacle avoidance does not require a conscious awareness avoided. have now tested hypothesis patient extinction following right temporoparietal damage. Extinction an...
Background and purpose Healthcare systems are challenged to provide access thrombectomy in acute stroke patients. Either the “drip ship” or “mothership” models result increased numbers of patients endovascular centre (ESC). We describe our approach for a “drip, ship, retrieve leave” model repatriating immediately within 24 hours thrombectomy. Methods included consecutive who underwent from January 2016 June 2018. Patients local region primary centres (PSC) repatriated those remote PSCs...
Hypoxemia and shock developed in a woman with atrial fibrillation who had been admitted for management of an ischemic stroke. Imaging (shown videos) showed thrombus transit across patent foramen ovale.
The 5-year recurrence risk after ischaemic stroke and transient attack (TIA) is 25-30%. Although inflammation may be a target for prevention trials, the contribution of plaque to acute cerebrovascular events remains unclear. We investigated association inflammatory cytokines high-sensitivity C-reactive protein (CRP) with recently symptomatic carotid atherosclerosis in prospective cohort study.Blood Imaging markers TIA BIO-TIA) multicentre study imaging patients TIA. Exclusion criteria were...
Atrial Fibrillation (AF) causes up to 20% of ischaemic strokes and 30% in some populations such as those over 80 years. Previous research our population showed that widespread adoption Direct Oral Anticoagulant (DOAC) prophylaxis had not been associated with a reduction AF stroke prevalence but there was considerable rate breakthrough patients receiving anticoagulation may be affected by increasing use DOACs.
The UK National Stroke Strategy (Department of Health 2007) states that patients should have access to a stroke service with neurointerventional capacity. This survey was conducted by the Clinical Standards Committee British Association Physicians get snapshot availability interventional treatments for in United Kingdom.Questionnaires covering endovascular stroke, e.g. intra-arterial thrombolysis and mechanical thrombectomy, were emailed all members October 2010. Where more than one response...
<h3>ABSTRACT</h3> The Stroke Improvement National Audit Programme (SINAP), now replaced by the Sentinel Programme, was established to provide comparative data on hospital performance indicators for stroke, but comparisons are only valid if case ascertainment is complete. In Gateshead we compared initial results from SINAP with those a pre-existing stroke register, which ran independently 11 months after SINAP9s introduction in 2010, as well Hospital Episode Statistics (HES) data. Of 315...
Summary Introduction Previous studies have shown an association between number of stroke admissions and outcomes. Small hospitals often support more remote areas we studied national data to determine if exists hospital remoteness care. Methods Data from the Irish National Audit Stroke (INAS) on average admissions, adjusted mortality for ischaemic stroke, thrombolysis rate proportion with door needle (DTN) ≤45 min were analysed. Hospital was quantified by distance next hospital, nearest...
The Oxford Carotid Stenosis tool (OCST) and Essen Stroke Risk Score (ESRS) are validated to predict recurrent stroke in patients with without carotid stenosis. Symptomatic Atheroma Inflammation Lumen stenosis (SCAIL) score combines plaque inflammation on fluorodeoxyglucose positron-emission tomography (18FDG-PET). We compared SCAIL OCST ESRS ipsilateral recurrence symptomatic stenosis.We pooled three prospective cohort studies of recent (<30 days) non-severe ischaemic stroke/TIA internal...
Background: The adoption of direct oral anticoagulants (DOACs) has changed practice in prevention stroke atrial fibrillation (AF). We used Irish data national on and anticoagulation therapy over 9 years to investigate changes potential consequences prevalence thrombolysis. Methods: AF, anticoagulation, thrombolysis, from the National Audit Stroke (INAS) 2013–2021 were reviewed. proportion patients with ischemic (IS) intracerebral hemorrhage (IH) known AF admitted was determined. Effects age...
Inflammation is important in stroke. Anti-inflammatory therapy reduces vascular events coronary patients. 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) identifies plaque inflammation-related metabolism. However, long-term prospective cohort studies investigating the association between carotid inflammation, identified on 18F-FDG PET and risk of recurrent events, have not yet been undertaken patients with The Biomarkers Imaging Vulnerable Atherosclerosis Symptomatic...
Consistency in medical decision-making is ideally expected. This includes consistency between different clinicians so that the same patient will receive diagnosis regardless of assessing clinician. It also encompasses reliability as an individual clinician meaning at any given time or context, we apply process and principles to ensure decisions make do not deviate significantly from our peers indeed own past decisions. However, can be challenged when working within a busy healthcare system....