A5023581499- Acute Ischemic Stroke Management
- Atherosclerosis and Cardiovascular Diseases
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Adipokines, Inflammation, and Metabolic Diseases
- Venous Thromboembolism Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Lipoproteins and Cardiovascular Health
- Inflammasome and immune disorders
- Tracheal and airway disorders
- Palliative Care and End-of-Life Issues
- Intensive Care Unit Cognitive Disorders
- Cardiovascular Health and Disease Prevention
- Emergency and Acute Care Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Pharmaceutical Practices and Patient Outcomes
- Healthcare Policy and Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Healthcare Systems and Practices
- Diabetes and associated disorders
- Cytokine Signaling Pathways and Interactions
- Lung Cancer Diagnosis and Treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- Adrenal and Paraganglionic Tumors
- Intracranial Aneurysms: Treatment and Complications
Mater Misericordiae University Hospital
2016-2025
Health Research Board
2019-2025
University College Dublin
2019-2025
Beaumont Hospital
2016-2024
University College Cork
2024
St. Vincent's University Hospital
2024
Cork University Hospital
2024
United Nations Economic and Social Commission for Asia and the Pacific
2021-2024
Cambridge University Hospitals NHS Foundation Trust
2024
Cancer Trials Ireland
2021-2024
Background and Purpose- In randomized trials of symptomatic carotid endarterectomy, only modest benefit occurred in patients with moderate stenosis important subgroups experienced no benefit. Carotid plaque 18F-fluorodeoxyglucose uptake on positron emission tomography, reflecting inflammation, independently predicts recurrent stroke. We investigated if a risk score combining would improve the identification early Methods- derived prospective cohort study recent (<30 days) non-severe...
Recent randomised trials showed benefit for anti-inflammatory therapies in coronary disease but excluded stroke. The prognostic value of blood inflammatory markers after stroke is uncertain and guidelines do not recommend their routine measurement risk stratification.
Acromegaly is a rare condition characterized by excessive secretion of growth hormone (GH), which almost always due to pituitary adenoma. associated with significant morbidity such as hypertension, type 2 diabetes, cardiomyopathy, obstructive sleep apnoea, malignancy and musculoskeletal abnormalities. has also been increased mortality in several retrospective studies. This review will focus on the epidemiological data relating rates acromegaly, relationship between acromegaly malignancy,...
Anti-inflammatory therapies reduce major adverse cardiovascular events (MACE) in coronary artery disease but remain unproven after stroke. Establishing the subtype-specific association between inflammatory markers and recurrence risk is essential for optimal selection of patients randomized trials (RCTs) anti-inflammatory secondary stroke prevention.
<h3>Background and Objectives</h3> To determine whether carotid plaque inflammation identified by <sup>18</sup>F-fluorodeoxyglucose (<sup>18</sup>FDG)-PET is associated with late (5-year) recurrent stroke. <h3>Methods</h3> We did an individual-participant data pooled analysis of 3 prospective studies near-identical study methods. Eligible patients had recent nonsevere (modified Rankin Scale score ≤3) ischemic stroke/TIA ipsilateral stenosis (50%–99%). Participants underwent...
Introduction: Atrial fibrillation (AF) detected after stroke (AFDAS) may represent a distinct clinical entity to that of known AF (KAF). However, there is limited long-term outcome data available for patients with AFDAS. More information regarding prognosis in AFDAS required inform future trial design these patients. Patients and methods: We used (2015–2019) from national prospective registry consecutive acute ischaemic AF. was defined as new diagnosis on electrocardiograph or cardiac...
Inflammation promotes atherogenesis. Randomized controlled trials of anti-inflammatory therapies for prevention after stroke have not yet demonstrated clear benefit. IL-6 (interleukin-6) and hsCRP (high-sensitivity C-reactive protein) are independently associated with major adverse cardiovascular events poststroke may guide patient selection in future randomized trials. Optimal timing hsCRP/IL-6 measurement is unknown, as early blood levels be confounded by the inflammatory response to brain...
Background: For reasons poorly understood, strokes frequently occur in patients with atrial fibrillation (AF) despite oral anticoagulation. Better data are needed to inform randomised trials (RCTs) of new strategies prevent recurrence these patients. We investigate the relative contribution competing stroke mechanisms AF who have anticoagulation (OAC+) compared those anticoagulant naïve (OAC−) at time their event. Patients and methods: performed a cross-sectional study leveraging from...
Abstract Introduction the COVID-19 pandemic has brought decision-making process regarding cardiopulmonary resuscitation (CPR) into focus. The aim of this study is to compare rates Do-Not-Attempt-CPR (DNACPR) documentation in older hospitalised patients before and during pandemic. Methods was a retrospective repeated cross-sectional study. Data including co-morbidities status collected on 300 with from 1 March 31 May 2020. DNACPR aged ≥65 years diagnosis were compared those without admitted...
In pooled analyses of endarterectomy trials for symptomatic carotid stenosis, several subgroups experienced no net benefit from revascularization. The validated atheroma inflammation lumen-stenosis (SCAIL) score includes stenosis severity and measured by PET improves the identification patients with recurrent stroke compared alone. We investigated whether SCAIL in uncertain revascularization trials.We did an individual-participant data analysis 3 prospective cohort studies (Dublin Carotid...
Abstract Background Inflammation is an emerging target for the prevention and treatment of cardiovascular disease (CVD). This drug-target Mendelian randomization (MR) study aimed to predict on-target effects IL-18 inhibition on CVD risk. Furthermore, we explore cardio-metabolic traits, cardiac structure, function, identify potential adverse outcomes. Methods We selected five independent circulating IL-18-lowering variants around gene locus from Systematic Combined AnaLysis Olink Proteins...
The 5-year recurrence risk after ischaemic stroke and transient attack (TIA) is 25-30%. Although inflammation may be a target for prevention trials, the contribution of plaque to acute cerebrovascular events remains unclear. We investigated association inflammatory cytokines high-sensitivity C-reactive protein (CRP) with recently symptomatic carotid atherosclerosis in prospective cohort study.Blood Imaging markers TIA BIO-TIA) multicentre study imaging patients TIA. Exclusion criteria were...
Purpose: Pathologic studies suggest that unstable plaque morphology and inflammation are associated with cerebrovascular events. 18 F-fluorodeoxyglucose positron emission tomography ( FDG-PET) is a validated technique for non-invasive imaging of inflammation-related metabolism, MRI can identify morphologic features instability. The aim this study was to investigate the association selected characteristics vulnerability measured PET in patients symptomatic carotid stenosis. Methods: Patients...