A5061534662- Acute Ischemic Stroke Management
- Osteoarthritis Treatment and Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Amyotrophic Lateral Sclerosis Research
- Stroke Rehabilitation and Recovery
- Alzheimer's disease research and treatments
- Sex work and related issues
- Cerebrovascular and Carotid Artery Diseases
- Neuroendocrine Tumor Research Advances
- Genetic Neurodegenerative Diseases
- Neuroblastoma Research and Treatments
- Natural product bioactivities and synthesis
- Extracellular vesicles in disease
- Cholinesterase and Neurodegenerative Diseases
- Autophagy in Disease and Therapy
- Adolescent Sexual and Reproductive Health
- Neurogenetic and Muscular Disorders Research
- Fatty Acid Research and Health
- Gestational Diabetes Research and Management
- Radiomics and Machine Learning in Medical Imaging
- Poverty, Education, and Child Welfare
- Congenital Heart Disease Studies
- Atrial Fibrillation Management and Outcomes
- Inflammatory mediators and NSAID effects
Addenbrooke's Hospital
2008-2024
University of Cambridge
2011-2024
Indian Institute of Science Bangalore
2021-2024
Cambridge University Hospitals NHS Foundation Trust
2022-2023
American Institute of Ultrasound in Medicine
2023
King George's Medical University
2016-2022
Hindu College of Pharmacy
2021-2022
The University of Sydney
2018-2021
Royal Prince Alfred Hospital
2018
John Hunter Hospital
2017
Trauma to the knee joint is associated with significant cartilage degeneration and erosion of subchondral bone, which eventually leads osteoarthritis (OA), resulting in substantial morbidity healthcare burden. With no disease-modifying drugs clinics, current standard care focuses on symptomatic relief viscosupplementation. Modulation autophagy targeting senescence pathways are emerging as potential treatment strategies. Rapamycin has shown promise OA disease amelioration by upregulation, yet...
While clinical benefit from thrombolysis decreases with increase in time stroke onset, the relationship of acute physiologic tissue compartments and collateral response to onset remains unclear.We studied consecutive patients proximal arterial occlusions (n = 355) whole-brain perfusion CT angiography within 6 hours onset. Penumbra core were defined using voxel-based thresholds. Tissue mismatch was as ratio penumbra core. Collateral scores assessed a previously validated visual score.Mean...
Abstract Osteoarthritis (OA) is the most common joint disorder and currently affects >500 million patients worldwide, with ~60% of them also suffering from obesity. There no drug approved for human use that changes course OA progression. one comorbidities obesity, obesity‐related (ObOA) a serious health concern because it shows heightened severity tissue damage predominantly working population. Unresolved inflammation major driver ObOA, thus, resolving disease‐associated viable strategy...
INTRODUCTION The aim of this study was to assess the quality information available on world wide web parents children undergoing tonsillectomy. MATERIALS AND METHODS main data source from internet searches using five most popular search engines and keyword ‘tonsillectomy’ with default settings. first 50 links in each were evaluated LIDA Instrument (assessing accessibility, usability reliability criteria). We also assessed readability sites Flesch reading ease score (FRES). RESULTS Of 250...
The majority of established telestroke services are based on "hub-and-spoke" models for providing acute clinical assessment and thrombolysis. We report results from the first year successful implementation a locally telemedicine network, without need 1 or more hub hospitals, across largely rural landscape.
Current treatments for osteoarthritis (OA) offer symptomatic relief but do not prevent or halt the disease progression. Chronic low-grade inflammation is considered a significant driver of OA. Specialized proresolution mediators are powerful agents resolution have short in vivo half-life. In this study, we engineered Resolvin D1 (RvD1)-loaded nanoliposomal formulation (Lipo-RvD1) that targets and resolves OA-associated inflammation. This creates depot RvD1 molecules allows controlled release...
Excitotoxicity may contribute to neuronal and synaptic loss in Alzheimer's disease (AD). Aberrant levels of gephyrin, a post-synaptic receptor-stabilizing protein, could affect the inhibitory modulation excitatory impulses. We assayed gephyrin protein two brain areas susceptible AD, spared area, autopsy tissue from normal subjects (n=15) AD patients (n=5). Quantification was by in-gel immunodetection against known concentrations recombinant truncated standard. Gephyrin abundance...
A new antibody, active against the common tachykinin (TK) C-terminal, was used to study TK expression in patients with endocrine tumors and a possible association between plasma-TK levels symptoms of diarrhea flush metastasizing ileocecal serotonin-producing carcinoid (MSPCs).TK, serotonin chromogranin (CgA) immunoreactivity (IR) studied by immunohistochemistry tissue samples from 33 midgut carcinoids 72 other tumors. Circulating (P-TK) urinary-5 hydroxyindoleacetic acid (U-5HIAA)...
<h3>Background</h3> Increasing age is the single largest non-modifiable risk factor for ischaemic stroke. Animal models have substantiated view that related neuron vulnerability to ischaemia plays a role in stroke and other neurological diseases. Given key of penumbra pathophysiology, we hypothesised has an impact on penumbral tissue its acute determinants. <h3>Methods</h3> We studied prospective cohort patients (n=39) at mean time 154.7 min from onset, using state art whole brain perfusion...
Background: For reasons poorly understood, strokes frequently occur in patients with atrial fibrillation (AF) despite oral anticoagulation. Better data are needed to inform randomised trials (RCTs) of new strategies prevent recurrence these patients. We investigate the relative contribution competing stroke mechanisms AF who have anticoagulation (OAC+) compared those anticoagulant naïve (OAC−) at time their event. Patients and methods: performed a cross-sectional study leveraging from...
Patients with malignant serotonin-producing carcinoid tumours in the jejunum, ileum and caecum generally have long survival expectancy. In some patients, however, tumour progression is more rapid there a need to identify them at an early stage. The purpose of this study was determine if histopathological characteristics and/or Ki67 apoptotic indices are prognostic value cases metastatic disease. Eighty-one patients were included study; all had metastases their range 1–223 months. Five growth...
Predicting the course of behavioural variant frontotemporal dementia (bvFTD) remains a major clinical challenge. This study aimed to identify factors that predict survival and progression in bvFTD.Consecutive patients with clinically probable bvFTD were prospectively followed up over an 8-year period. Baseline neuropsychological variables, presence known pathogenic gene mutation systematic visual magnetic resonance imaging assessment at baseline examined as candidate predictors using...
Abstract Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are well-recognised as an extended disease spectrum. This study hypothesised that cortical hyperexcitability, early pathophysiological abnormality in ALS, would distinguish cognitive phenotypes, a surrogate marker of pathological burden. 61 patients with matched for duration (pure motor n = 39; ALS coexistent FTD, ALS-FTD, 12; cognitive/behavioural abnormalities not meeting FTD criteria, ALS-Cog, 10) 30...
Abstract Background Frailty—the loss of physiological reserve to withstand a stressor event—is associated with poorer outcomes following acute stroke reperfusion therapies. However, the mechanisms underlying this relationship are poorly understood. This study investigated association between frailty and penumbral volumes in hyperacute ischemic stroke. Methods Total lesion (comprising infarct core volumes) were measured using computed tomography (CT) perfusion imaging give fraction within...
Objectives Timely thrombolysis of ischaemic stroke improves functional recovery, yet its delivery nationally is challenging due to shortages in the specialist workforce and large geographical areas. One solution remote input regional centres via telemedicine. This study evaluates usage key metrics performance East England Stroke Telemedicine Partnership—the largest telestroke service UK—in providing hyperacute care. Design Prospective observational study. Setting The Partnership provides a...
Despite use in clinical practice and major positive trials of thrombolysis, non-contrast computed tomography (NCCT) is not sensitive for identifying penumbral tissue acute stroke. This study evaluated how physiological imaging using CT perfusion (CTP) could add to the diagnostic utility an NCCT inform decisions regarding thrombolysis.Forty datasets containing CTP were retrospectively identified from a cohort consecutive stroke patients. Two sets observers (n = 6) neuroradiologist images...
Lung cancer is a severe type of with highest mortality rate among all cancers. Natural products such as theaflavins, quercetin, arctigenin, EGCG, curcumin, and cinnamaldehyde are quite capable anti-inflammatory anti-cancerous agents which able to suppress ERK-MAPK, JAK-STAT, p38, AMPK, PI3K/Akt, MAPK, mTOR, STAT3, Wnt/β-catenin signal transduction pathways. These APIs inhibit the inflammatory proliferator enzymes COX-2, caspase-3, MMP-9, MMP-2, NF-κB, p53, Bcl-xL, Bcl-2,Mcl-1, miR-210,...
Lung cancer has the highest mortality rate as compared to other cancers. The anti-proliferative and antioxidant potential of epigallocatechin gallate (EGCG) Theaflavin -3,3’-digallate (TF3) can play a major role in treatment if delivered efficiently. To improve chemical stability medicinal EGCG TF3 respiratory tract, spanlastic is developed which composed Tween-80, Span-60, cholesterol encapsulate inside its vesicular structure deliver it specifically target cells. layer will produce...
Dhat syndrome, a clinical condition related to semen loss in urine often found among males India, has rarely been described as separate females. Women with the syndrome complain of passing vaginal discharge and can be excessively concerned preoccupied it, attributing various physical symptoms fluids.This study aimed assess sociodemographic profiles female patients their perceived stress, disability sexual functioning.Sociodemographic details 70 females non-pathological were evaluated...
CT-based perfusion and collateral imaging is increasingly used in the assessment of patients with acute stroke. Time stroke onset a critical factor determining eligibility for benefit from thrombolysis. Animal studies predict that volume ischemic penumbra decreases time. Here, we evaluate if CT able to detect relationship between or status, as assessed by CT, time since onset.We studied 53 consecutive proximal vessel occlusions, mean (SD) age 71.3 (14.9) years, at 125.2 (55.3) minutes onset,...