A5042649011- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Venous Thromboembolism Diagnosis and Management
- Intracranial Aneurysms: Treatment and Complications
- Cardiovascular Health and Disease Prevention
- Platelet Disorders and Treatments
- Stroke Rehabilitation and Recovery
- Atrial Fibrillation Management and Outcomes
- Inflammatory Biomarkers in Disease Prognosis
- Autoimmune Neurological Disorders and Treatments
- Balance, Gait, and Falls Prevention
- Blood Coagulation and Thrombosis Mechanisms
- Moyamoya disease diagnosis and treatment
- Clinical practice guidelines implementation
- Cerebral Palsy and Movement Disorders
- Genetic Neurodegenerative Diseases
- Biosimilars and Bioanalytical Methods
- Complement system in diseases
- Sarcoidosis and Beryllium Toxicity Research
- Epilepsy research and treatment
- Cardiovascular and Diving-Related Complications
- Neurological Disorders and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Amyloidosis: Diagnosis, Treatment, Outcomes
Tallaght University Hospital
2016-2025
Trinity College Dublin
2015-2025
Boehringer Ingelheim (United States)
2023-2025
The Royal Free Hospital
2013-2024
National Hospital for Neurology and Neurosurgery
1999-2024
University College London
2013-2024
Health and Education Research Management and Epidemiologic Services (United States)
2023
Connolly Hospital Blanchardstown
2023
Science Foundation Ireland
2022
University Medical Center Utrecht
2021
Atherosclerotic stenosis of the internal carotid artery is an important cause stroke. The aim this guideline to analyse evidence pertaining medical, surgical and endovascular treatment patients with stenosis. These guidelines were developed based on ESO standard operating procedure followed Grading Recommendations, Assessment, Development, Evaluation (GRADE) approach. working group identified relevant questions, performed systematic reviews meta-analyses literature, assessed quality...
In the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS), early recurrent carotid stenosis was more common in patients assigned to endovascular treatment than it endarterectomy (CEA), raising concerns about long-term effectiveness of treatment. We aimed investigate risks restenosis included CAVATAS.413 who were randomly CAVATAS completed for (200 had 213 endarterectomy) prospective clinical follow-up at a median 5 years duplex ultrasound 4 years. investigated cumulative...
Background and Purpose— The long-term outcome of endovascular intervention compared with best medical management patients symptomatic vertebral artery stenosis is uncertain. We therefore these treatments in a randomized trial follow-up. Methods— In the international, multicenter C arotid A nd V ertebral rtery T ransluminal ngioplasty S tudy, 16 were equal proportions to receive therapy (balloon angioplasty or stenting) treatment alone. An independent neurologist followed up for as long 8...
The risk of stroke associated with carotid artery restenosis after stenting or endarterectomy is unclear. We aimed to compare the long-term these treatments and investigate if causes in a secondary analysis International Carotid Stenting Study (ICSS).ICSS parallel-group randomised trial at 50 tertiary care centres Europe, Australia, New Zealand, Canada. Patients aged 40 years older symptomatic stenosis measuring 50% more were randomly assigned either 1:1 ratio. Randomisation was...
Atherosclerotic stenosis of the internal carotid artery is an important cause stroke. The aim this guideline to analyse evidence pertaining medical, surgical and endovascular treatment patients with stenosis. These guidelines were developed based on ESO standard operating procedure followed Grading Recommendations, Assessment, Development, Evaluation (GRADE) approach. working group identified relevant questions, performed systematic reviews meta-analyses literature, assessed quality...
Background and Purpose— Carotid Vertebral Artery Transluminal Angioplasty Study (CAVATAS) patients with carotid stenosis were randomized between endovascular treatment endarterectomy. The rates of residual severe restenosis their contribution to recurrent symptoms was unclear. Methods— Endovascular treated by balloon angioplasty alone (88%) or stenting (22%). Patches used in 63% endarterectomy patients. categorized as mild (0% 49%), moderate (50% 69%), (70% 99%), occluded, using standardized...
Background —The hyperperfusion syndrome is a recognized complication of carotid endarterectomy. Reports cerebral injury following internal artery (ICA) angioplasty are few, and this has never been reported stenting. Case Description —A 68-year-old normotensive man was referred to our hospital for assessment 5 months after experiencing left hemispheric ischemic stroke. Angiography confirmed 95% stenosis the ICA. Left percutaneous transluminal stenting performed without any initial...
Flow cytometric studies suggest that platelets are activated in ischaemic stroke or transient attack (TIA). However, few have measured circulating leucocyte-platelet complexes this patient population. Whole blood flow cytometry was used to quantify the expression of CD62P-, CD63-, and PAC1-binding, percentages acute (1-27 d, n = 79) convalescent (79-725 70) cerebrovascular disease (CVD) patients compared with controls without CVD (n 27). We performed a full count, plasma levels soluble...
Summary The percentage of reticulated platelets (% RP) could be a useful marker increased platelet production and/or turnover in patients with activation, but few flow cytometric studies have measured the % RP ischaemic cerebrovascular disease (CVD). Whole blood cytometry using thiazole orange was performed to compare early (1–27 d, n = 79) and late phases (79–725 70) after stroke or transient attack (TIA) controls without CVD ( 27). impact aspirin dose escalation (75–300 mg/d) on...
Introduction In ischaemic stroke care, fast reperfusion is essential for disability free survival. It unknown if bypassing thrombolysis centres in favour of endovascular thrombectomy (mothership) outweighs transport to the nearest centre alteplase and then transfer (drip-and-ship). We use conditional probability modelling determine impact treatment times on decision-making acute stroke. Materials methods Probability good outcome was modelled using a previously published framework, data from...
Background and Purpose— Open-cell carotid artery stents are associated with a higher peri-procedural stroke risk than closed-cell stents. However, the effect of stent design on long-term durability stenting (CAS) is unknown. We compared medium- to restenosis ipsilateral between patients treated open-cell versus in ICSS (International Carotid Stenting Study). Methods— Patients symptomatic stenosis were randomized CAS or endarterectomy followed duplex ultrasound for median 4.0 years. analyzed...
Plain Language SummaryWhat is this summary about?Adalimumab, also known by the brand name Humira®, a biologic drug that approved for treatment of many autoimmune conditions including rheumatoid arthritis, Crohn's disease, and chronic plaque psoriasis. Adalimumab-adbm, Cyltezo®, biosimilar to Humira®. While biologics are large, complex organic molecules made with living cells grown in culture, type highly similar its reference product, or original biologic.The VOLTAIRE clinical trials...
Atherosclerosis is believed to be a minor cause of TIA and stroke in younger middle-aged patients. However, data from large cohorts are limited. This study investigates the prevalence extracranial intracranial atherosclerosis patients aged 18-55 years multinational sifap1 study.From cohort (n = 5,023), we analyzed subset with complete carotid ultrasound studies. Patients arterial dissections, vasculitis, mobile thrombi were excluded. Among remaining 2,187 (men: n 1,319; 18-44 years: 744),...
AbstractVascular events commonly recur in stroke patients on aspirin, and may reflect incomplete inhibition of platelet function with aspirin therapy. The analyser (PFA-100) activates platelets by aspirating a blood sample at moderately high shear rate through capillary to biologically active membrane central aperture. is coated collagen, either ADP (C-ADP) or epinephrine (C-EPI). time taken for activated adhere, aggregate, occlude the aperture called closure time. Previous studies have...
<b><i>Article abstract</i></b> A 25-year-old woman presented with a subacute confusional state, headaches, unsteadiness, myoclonus, seizures, and an amnesic syndrome as manifestation of Hashimoto’s encephalopathy. Investigations showed biochemical hypothyroidism, raised thyroid microsomal antibodies, weakly positive antineuronal antibodies. T2-weighted MRI the brain bilateral symmetric areas increased signal in mesial temporal lobes hippocampi that had low intensity on T1-weighted imaging....
We evaluated whether basilar dolichoectasia is associated with markers of cerebral small vessel disease in younger transient ischemic attack and stroke patients.We used data from the SIFAP1 study (Stroke Young Fabry Patients), a large prospective, hospital-based, screening for young (<55 years) attack/stroke patients whom detailed clinical brain MRI were obtained, subtyping TOAST classification (Trial ORG 10172 Acute Stroke Treatment) was performed.Dolichoectasia found 508 3850 (13.2%)...
A 43-year-old woman presented with clinical and electrophysiologic features of stiff person syndrome (SPS), without abdominal or lumbar paraspinal muscle involvement. Investigations revealed metastatic adenocarcinoma the lung positive anti-Ri antibodies. Her condition improved diazepam, baclofen, tizanidine, palliative chemotherapy. Screening for an underlying malignancy antibodies should be considered in patients SPS when presentation is atypical.
The risk of stroke in patients with recently symptomatic carotid stenosis is considerably higher than asymptomatic stenosis. In the present study it was hypothesised that excessive platelet activation might partly contribute to this difference.A full blood count done and whole flow cytometry used measure surface expression CD62P, CD63, PAC1 binding percentage leucocyte-platelet complexes acute (0-21 days, n = 19) convalescent (79-365 days) (n 16) severe (> or =70%) Most were treated aspirin...