A5067598472- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Cardiac Structural Anomalies and Repair
- Cardiac, Anesthesia and Surgical Outcomes
- Electric and Hybrid Vehicle Technologies
- Gear and Bearing Dynamics Analysis
- Brake Systems and Friction Analysis
- Acute Kidney Injury Research
- Mechanical Engineering and Vibrations Research
- Vehicle Dynamics and Control Systems
- Cardiac Ischemia and Reperfusion
- Tribology and Lubrication Engineering
- Respiratory Support and Mechanisms
- Flexible and Reconfigurable Manufacturing Systems
- Hemodynamic Monitoring and Therapy
- Cardiac pacing and defibrillation studies
- Tribology and Wear Analysis
- Human-Animal Interaction Studies
- Engineering and Materials Science Studies
- Heart Failure Treatment and Management
- Airway Management and Intubation Techniques
- Adhesion, Friction, and Surface Interactions
- Sepsis Diagnosis and Treatment
- Veterinary Practice and Education Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
Humboldt-Universität zu Berlin
2010-2025
Charité - Universitätsmedizin Berlin
2010-2025
Deutsches Herzzentrum der Charité
2021-2025
Outcomes Research Consortium
2024-2025
Cleveland Clinic
2024-2025
German Centre for Cardiovascular Research
2022-2025
Freie Universität Berlin
2022-2025
Karlsruhe Institute of Technology
2012-2025
Berlin Heart (Germany)
2025
ETH Zurich
2024
According to recent studies, early and clearly defined customer's demands provider's are necessary elements for the future success of a product. Product profiles within scope ASD – Agile Systems Design describe these demands. As product characterizations in development phases, do not anticipate technical realization product, but rather model benefits as use cases, requirements boundary conditions thus include value-added attributes. By this, represent interdisciplinary design objective form...
OBJECTIVEAcute kidney injury (AKI) requiring renal replacement therapy (RRT) after heart transplantation (OHT) is common and impairs outcomes. This study aimed to identify independent donor recipient risk factors associated with RRT OHT.DESIGNRetrospective data analysis.SETTINGThe were collected from clinical routines in a maximum care university hospital.PARTICIPANTSPatients who underwent OHTINTERVENTIONSThe authors retrospectively analyzed 264 patients OHT between 2012 2021. 189 eligible...
Abstract Introduction Purulent bacterial pericarditis is a potentially fatal disease with mortality rates reaching 100% if left untreated. Case presentation We present the case of 33-year-old Caucasian male patient who developed cardiac tamponade, most likely caused by pyogenic liver abscess communicating pericardium. Treatment antibiotics, extended sepsis therapy, and drainage led to full recovery. Conclusion This report describes rare but differential diagnosis aortic dissection serves as...
Chronic-kidney-disease (CKD) is prevalent among adults undergoing noncardiac surgery, with surgery-related factors potentially worsening CKD or triggering acute kidney injury (AKI). We hypothesized that patients experience more function decline within one to two years post-surgery than those without CKD, particularly if they develop AKI. conducted a single-center retrospective cohort study, including surgery documented creatinine preoperative and between 1 2 after surgery. The primary...
Abstract Post-cardiotomy cardiogenic shock (PCCS) is a critical condition characterized by persistent low cardiac output syndrome (LCOS) that manifests either as an inability to wean from cardiopulmonary bypass (CPB) or severe dysfunction in the immediate postoperative period despite optimal medical therapy. With incidence of 2% 20%, PCCS associated with high morbidity, mortality, and healthcare resource utilization. This review explores pathophysiology while emphasizing mechanisms such...
Abstract Cardiac arrest is a critical emergency in cardiovascular medicine, requiring rapid, multidisciplinary interventions to enhance patient survival and neurological outcomes. This review explores the unique challenges of managing out-of-hospital in-hospital cardiac arrest, with focus on mechanical circulatory support extracorporeal cardiopulmonary resuscitation for selected patients. While management should prioritize rapid transport specialized centers, may allow immediate,...
Abstract Produktprofile sind eine praxisorientierte Hilfestellung, um neue Systemgenerationen zielgerichtet für die Bedürfnisse der Kunden und Anwender zu entwickeln. Dieser Beitrag zeigt anhand von zwei Fallstudien, wie KI bei Definition Kunden- Anwendernutzen unterstützen kann. In Fallstudie 1 werden dazu aus Kundenrezensionen Use Cases Produktverbesserungsvorschläge abgeleitet. 2 Eigenschaften batterieelektrischer Fahrzeuge basierend auf Verkaufszahlen priorisiert.
The risk of regional analgesia catheter-related infections in immunocompromised patients remains uncertain. We therefore tested the hypotheses that appear earlier and are more severe, antibiotic prophylaxis is effective than immunocompetent patients. Data were extracted from Network for Safety Regional Anesthesia Acute Pain Therapy (net-ra) registry 2007 to 2022. used multivariable cox ordinal regression assess effect immune function indicated by surgery on infection onset severity. analyzed...
Temporary mechanical circulatory support (tMCS) is a life-saving treatment option for patients in cardiogenic shock (CS), but many aspects such as patient selection, initiation threshold and optimal modality selection remain unclear. This study describes standard operating procedure (SOP) tMCS allocation CS presents outcome data before after implementation. Data from 421 treated with between 2018 2021 were analyzed. In 2019, we implemented new SOP allocating to modalities. The association...
BACKGROUND Increasing evidence from randomised controlled trials supports the implementation of a six-measure care bundle proposed by Kidney Disease Improving Global Outcomes (KDIGO) guidelines in patients at high risk for acute kidney injury (AKI) to reduce its incidence after cardiac surgery. OBJECTIVE To assess compliance with KDIGO clinical practice. DESIGN Prospective observational multinational study. SETTING Six international tertiary centres, February 2021 November 2021. PATIENTS...
Summary Introduction The number of tracheal intubation attempts required to reach proficiency in videolaryngoscopy with hyperangulated blades is unknown. Understanding this training requirement might guide for clinicians who perform laryngoscopy. We therefore performed a planned sub‐analysis randomised controlled trial comparing success vs. direct laryngoscopy determine the intubations videolaryngoscope blade needed provide an acceptable first‐attempt rate. Methods included from were...
Temporary mechanical circulatory support (tMCS) devices have become a standard treatment option in cardiogenic shock but are associated with high complication rates. This study analyzes common complications modern tMCS and their impact on mortality depending the approach.
<i>Background:</i> C-reactive protein (CRP) is a possible causative factor of the destructive processes observed during weeks after myocardial infarction. <i>Methods:</i> We developed clinically relevant animal model including removal CRP from blood plasma utilizing specific adsorber and visualization infarct scar in living by cardiovascular magnetic resonance imaging as tool to investigate impact acute <i>Results:</i> describe facets this system kinetics...
Background and Study Aim: Patients with long-standing inflammatory bowel disease (IBD) have an increased risk of developing colonic dysplasias. Dysplastic changes in flat mucosa are likely to be missed by conventional colonoscopy. Endoscopic fluorescence imaging, using 5-aminolevulinic acid (5-ALA) as photosensitizer, has evolved a new technique differentiate between normal dysplasia. We combined this random biopsies prospectively evaluate the occurrence dysplasias patients IBD. Methods: 52...
The cardiac surgery-related ischemia-reperfusion-related oxidative stress triggers the release of cytotoxic reactive oxygen and nitrogen species, contributing to organ failure ultimately influencing patients' short- long-term outcomes. Selenium is an essential co-factor for various antioxidant enzymes, thereby endogenous anti-inflammatory defense mechanisms. Given these selenium's pleiotropic functions, we investigated effect a high-dose selenium-based perioperative strategy on functional...
Cardiac surgery, post-cardiotomy cardiogenic shock (PCCS), and temporary mechanical circulatory support (tMCS) provoke substantial inflammation. We therefore investigated whether a selenium-based, anti-inflammatory strategy would benefit PCCS patients treated with tMCS in post-hoc analysis of the sustain CSX trial. Post-hoc receiving for Sustain trial, which effects high-dose selenium on postoperative organ dysfunction cardiac surgery patients. Primary outcome: duration therapy. Secondary...
Abstract OBJECTIVES This study investigates our enhanced recovery after minimally invasive cardiac surgery program “enhanced surgery” (ERMICS) following a ‘Zero ICU’ concept compared to standard-of-care treatment in terms of safety and clinical efficacy. METHODS All patients who underwent mitral valve for primary severe regurgitation between 2021 2023 were included. Propensity score matching (2:1) was performed received those ERMICS. Patients treated with the ERMICS approach transferred...