A5030583942- Spine and Intervertebral Disc Pathology
- Total Knee Arthroplasty Outcomes
- Orthopedic Infections and Treatments
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Orthopaedic implants and arthroplasty
- Bone fractures and treatments
- Spinal Fractures and Fixation Techniques
- Shoulder Injury and Treatment
- Hip and Femur Fractures
- Medical Imaging and Analysis
- Reproductive System and Pregnancy
- Viral Infections and Immunology Research
- Pelvic and Acetabular Injuries
- Shoulder and Clavicle Injuries
- Viral gastroenteritis research and epidemiology
- Cervical and Thoracic Myelopathy
- Orthopedic Surgery and Rehabilitation
- Clinical practice guidelines implementation
- Cardiac, Anesthesia and Surgical Outcomes
- Spinal Hematomas and Complications
- Trauma Management and Diagnosis
- Musculoskeletal pain and rehabilitation
- Streptococcal Infections and Treatments
- Trauma and Emergency Care Studies
University of California, Los Angeles
2017-2025
UCLA Health
2021-2023
Orthopaedic Trauma Association
2022
Smith & Nephew (Switzerland)
2022
Brown University
2022
Park University
2022
Globus Medical (United States)
2022
Cedars-Sinai Kerlan-Jobe Institute
2022
Stryker (United States)
2022
UCLA Medical Center
2021
Abstract To understand the genetic drivers of immune recognition and evasion in colorectal cancer, we analyzed 1,211 cancer primary tumor samples, including 179 classified as microsatellite instability–high (MSI-high). This set includes The Cancer Genome Atlas cohort 592 completed here. MSI-high, a hypermutated, immunogenic subtype had high rate significantly mutated genes important immune-modulating pathways antigen presentation machinery, biallelic losses B2M HLA due to copy-number...
As primary total knee arthroplasty volume continues to increase, so will the number of revision (rTKA) procedures. The purpose this study is provide an updated perspective on incidence, indications, and financial burden rTKA in United States.This was a retrospective epidemiologic analysis using National Inpatient Sample. International Classification Diseases ninth tenth codes were used identify patients who underwent create cohorts based indications from 2012 2019. regional trends for length...
As the global polio eradication initiative prepares to cease use of oral vaccine (OPV) in 2020, there is increasing interest understanding if vaccination provides non-specific immunity other infections so that consequences this transition can be effectively planned for and mitigated.Data were collected from infants an urban slum Bangladesh (Mirpur, Dhaka) as part performance rotavirus vaccines developing countries (PROVIDE) study. Following with trivalent (tOPV) at 6, 10, 14 weeks, randomly...
Pakistan is one of only three countries where poliovirus circulation remains endemic. For the Polio Eradication Program, identifying high risk districts essential to target interventions and allocate limited resources. Using a hierarchical Bayesian framework we developed spatial Poisson hurdle model jointly probability or more paralytic polio cases, number cases that would be detected in event an outbreak. Rates underimmunization, routine immunization, population immunity, as well...
BackgroundThe number of anatomic total shoulder (TSA), hemiarthroplasty (HA), and reverse arthroplasties (RTSA) is rapidly increasing in the United States. Stemless arthroplasty has numerous theoretical advantages, including preserved bone stock, decreased operating time, reduced rate intraoperative humerus fracture, flexibility reconstruction. Only recently studies with more than 5 years mean follow-up have become available.MethodsThe MEDLINE database was systematically queried to identify...
ABSTRACT Denosumab has been used successfully to treat disease‐associated osteoclast overactivity, including giant cell tumor of bone. Given its mechanism action, denosumab is a potent potential treatment other bone dysplasias central granuloma (CGCG), aneurysmal cyst (ABC), and cherubism. Relatively little known about the safety efficacy in patients with these conditions, especially children. We report on 3 pediatric treated over 3‐year period at UCLA Medical Center (Los Angeles Santa...
Trivalent oral polio vaccine (tOPV) was replaced worldwide from April, 2016, by bivalent types 1 and 3 (bOPV) one dose of inactivated (IPV) where available. The risk transmission type 2 poliovirus or Sabin virus on re-introduction resurgence after this switch is not understood completely. We aimed to assess the a vaccination campaign with monovalent (mOPV2).We did an open-label cluster-randomised trial in villages Matlab region Bangladesh. randomly allocated (clusters) either: tOPV at age 6...
Prediction of nonhome discharge after open reduction internal fixation (ORIF) distal femur fractures may facilitate earlier planning, potentially decreasing costs and improving outcomes. We aim to develop algorithms predicting time ORIF identify features important for model performance. This is a retrospective cohort study adults in the American College Surgeons National Surgical Quality Improvement Program database who underwent between 2010 2019. The primary outcome was discharge,...
Aim: We aim to develop a machine learning (ML)-driven predictive algorithm for patient-reported dysphagia after instrumented cervical fusion. Additionally, we identify features the prediction of and web-based risk calculator outcome prediction. Methods: identified consecutive adults who underwent fusion at single institution between 2013-2020. developed regression-based ML-based prognostic models assessed model performance using discrimination calibration. patient driving most effective...
One of the challenges facing Global Polio Eradication Initiative is efficiently directing limited resources, such as specially trained personnel, community outreach activities, and satellite vaccinator tracking, to most at-risk areas maximize impact interventions. A validated predictive model wild poliovirus circulation would greatly inform prioritization efforts by accurately forecasting at greatest risk, thus enabling effect program Using Nigerian acute flaccid paralysis surveillance data...
As more regions approach malaria elimination, understanding how different interventions interact to reduce transmission becomes critical. The Lake Kariba area of Southern Province, Zambia, is part a multi-country elimination effort and presents particular challenge as it an interconnected region variable intensities. In 2012–13, six rounds mass test-and-treat drug campaigns were carried out in the region. A spatial dynamical model area, with climate modeled at village scale, was calibrated...
Continuous-infusion 5-fluorouracil (5FU) and calcium leucovorin plus nab-paclitaxel oxaliplatin have been shown to be active in patients with pancreatic cancer. As a protracted low-dose infusion, 5FU is antiangiogenic, has synergy bevacizumab. the treatment of breast cancer, bevacizumab are also synergetic. In this paper we retrospectively analyze survival 65 advanced cancer who were treated continuous (metronomic) chemotherapy given conjunction conventional anti-VEGF therapy. Since July...
Objectives: To evaluate the initial complications and short-term readmissions reoperations after open reduction internal fixation (ORIF) versus acute total hip arthroplasty (THA) for elderly acetabular fractures. Design: Retrospective database review. Setting: All hospitalizations in National Readmissions Database Inpatient Sample. Patients/Participants: Patients 60 years of age or older with closed fractures managed surgically identified from Sample between 2010 2019. Intervention: Acute...
Cementless total knee arthroplasties (TKAs) have gained renewed interest due to improved implant designs and lower rates of revision than its cemented counterparts. The purpose this study was compare between vs cementless TKAs within 1 year primary arthroplasty.This a retrospective review from the PearlDiver Patient Record Database. International Classification Diseases Current Procedural Terminology codes were used identify patients who had undergone subsequent surgical revisions. An...
Posterior cervical foraminotomy is a commonly performed procedure to address radiculopathy through direct decompression of the neural foramen by partially resecting dorsal aspect facet joint. The an alternative anterior approaches such as discectomy and fusion disc arthroplasty, which require complete foraminal stenosis that cause radiculopathy. has evolved from open minimally invasive techniques including endoscopic methods, recently increased in interest spine surgeons. This review...
Background: Biportal endoscopic spine surgery is an effective minimally invasive technique for treating common lumbar pathologies. We aim to evaluate the impact of intraoperative tranexamic acid (TXA) use on postoperative blood loss in biportal decompression surgery. Methods: Patients undergoing discectomies and decompressions either by same day or overnight stay at a single institution beginning October 2021 were prospectively enrolled. This study was non-randomized, non-blinded with first...
Introduction: Distal femur fractures are complex injuries that often present with multiple fragments, posing notable challenges to fixation. This study aimed (1) use preoperative CT scans graphically display fracture lines in intra-articular distal and (2) identify common patterns these injuries. Methods: All skeletally mature patients underwent surgical fixation of Orthopaedic Trauma Association type 33C between 2012 2022 were identified across two level 1 trauma centers (n = 63)....
We investigated the efficacy, safety and cost of lime wash household walls plus treatment sand fly breeding places with bleach (i.e. environmental management or EM), insecticide impregnated durable wall lining (DWL), bed net impregnation slow release (ITN) for control in Indian sub-continent.This multi-country cluster randomized controlled trial had 24 clusters each three sites eight per high, medium low density stratum. Every included 45-50 households. Five households from were randomly...
Aims Aseptic loosening is a major cause of failure in cemented endoprosthetic reconstructions. This paper presents the long-term outcomes custom-designed cross-pin fixation construct designed to minimize rotational stress and subsequent aseptic selected patients. The will also examine survivorship modes when using this technique. Patients Methods A review 658 consecutive, prospectively collected reconstructions for oncological diagnoses at single centre between 1980 2017 was performed. total...
Background: The coronavirus disease 2019 (COVID-19) pandemic significantly disrupted athletic activities, including those in the Pacific 12 (Pac-12) Conference of National Collegiate Athletic Association. It is currently unknown how disruption training and competition impacted athletes’ risk injury upon resumption activities. Purpose: To describe compare rate, timing, mechanism, severity injuries among collegiate athletes across multiple sports Pac-12 before after COVID-19...
To assess the biomechanical differences between linked and unlinked constructs in young osteoporotic cadavers addition to sawbones.
A priority of the Global Polio Eradication Initiative (GPEI) 2013–2018 strategic plan is to evaluate potential impact on polio eradication resulting from expanding one or more Supplementary Immunization Activities (SIAs) children beyond age five-years in endemic countries. It has been hypothesized that such expanded group (EAG) campaigns could accelerate by eliminating immunity gaps older may have resulted past periods low vaccination coverage. Using an individual-based mathematical model,...
Despite extensive research to identify biomarkers of response in patients with non-muscle-invasive bladder cancer (NMIBC), there is no biomarker date that can serve this purpose. Herein, we report how leveraged serial urine samples query a panel cytokines at varying time points an attempt predictive NMIBC.Serial were collected from 50 intermediate- or high-risk NMIBC enrolled phase II study, evaluating intravesical BCG ± intradermal HS-410 therapy. Samples baseline, week 7, 13, 28, and end...