A5080072407- Musculoskeletal pain and rehabilitation
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Urinary Bladder and Prostate Research
- Pelvic floor disorders treatments
- Pain Mechanisms and Treatments
- Endometriosis Research and Treatment
- Dermatology and Skin Diseases
- Pain Management and Placebo Effect
- Stress Responses and Cortisol
- Pregnancy-related medical research
- Pediatric Pain Management Techniques
- Myofascial pain diagnosis and treatment
- Sexual function and dysfunction studies
- Cancer survivorship and care
- Urinary Tract Infections Management
- Heart Rate Variability and Autonomic Control
- Functional Brain Connectivity Studies
- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
- Cancer, Stress, Anesthesia, and Immune Response
- Menstrual Health and Disorders
- Rheumatoid Arthritis Research and Therapies
- Pituitary Gland Disorders and Treatments
- Uterine Myomas and Treatments
- Inflammatory mediators and NSAID effects
University of Michigan–Ann Arbor
2016-2025
Michigan Medicine
2018-2025
Michigan United
2016-2023
University of Oxford
2023
University of Iowa
2012-2021
Pain and Headache Center
2016-2021
Angeles University Foundation
2021
Macomb Community College
2019
Ann Arbor Center for Independent Living
2018
Tianjin Medical University
2016
Abstract Endogenous opioid system dysfunction potentially contributes to chronic pain in fibromyalgia (FM), but it is unknown if this related established neurobiological markers of hyperalgesia. We previously reported that µ-opioid receptor (MOR) availability was reduced patients with FM as compared healthy controls several pain-processing brain regions. In the present study, we pain-evoked functional magnetic resonance imaging endogenous MOR binding and clinical ratings female opioid-naive...
It is unknown how chronic inflammation impacts the brain. Here, we examined whether higher levels of peripheral were associated with brain connectivity and structure in 54 rheumatoid arthritis patients using functional structural MRI. We show that are more positive connections between inferior parietal lobule (IPL), medial prefrontal cortex, multiple networks, as well reduced IPL grey matter, these patterns predicted fatigue, pain cognitive dysfunction. At a second scan 6 months later, some...
BACKGROUND Sleep disturbance is a common clinical complaint of oncology patients and contributes to substantial morbidity. However, because most sleep studies have been cross‐sectional, associations between quality distress in with ovarian cancer over time remain unclear. This prospective longitudinal study examined rates disturbance; contributions depression, anxiety, medication use life (QOL) during the first year after diagnosis among women cancer. METHODS Women pelvic mass completed...
Toll-like receptors (TLR) are known to play a role in chronic pain, from animal models and limited research humans, but their interstitial cystitis/bladder pain syndrome (IC/BPS) is unknown. Similarly, alterations of the hypothalamic-pituitary-adrenal axis have been reported some conditions. Our objectives were identify inflammatory processes that might distinguish individuals with IC/BPS healthy controls (HC) examine associations symptoms. Female participants (58IC/BPS patients 28HCs)...
Chronic overlapping pain conditions (COPCs) are characterized by aberrant central nervous system processing of pain. This "centralized pain" phenotype has been described using a large and diverse set symptom domains, including the spatial distribution pain, intensity, fatigue, mood imbalances, cognitive dysfunction, altered somatic sensations, hypersensitivity to external stimuli. Here, we used 3 cohorts, patients with urologic chronic pelvic syndrome, mixed cohort other COPCs, healthy...
A critical component of brain network architecture is a robust hub structure, wherein regions facilitate efficient information integration by occupying highly connected and functionally central roles in the network. Across wide range neurological disorders, seem to be disrupted, character this disruption can yield insights into pathophysiology these disorders. We applied network-based approach examine topology fibromyalgia, chronic pain condition with prominent nervous system involvement....
Adverse Childhood Experiences (ACEs) such as sexual and physical violence, serious illness, bereavement have been linked to number of chronic pain conditions in adulthood, specifically urologic pelvic syndrome (UCPPS). We sought characterize the prevalence ACEs UCPPS using a large well-characterized cohort comparison with group healthy controls. also determine association ACE severity psychological factors known impact whether are associated patterns improvement or worsening symptom over...
Until recently, the predominant pathology of chronic pelvic pain conditions was thought to reside in peripheral tissues. However, mounting evidence from neuroimaging studies suggests an important role central nervous system pathogenesis these conditions. In present cross-sectional study, proton magnetic resonance spectroscopy (1H-MRS) brain conducted female patients with urologic syndrome (UCPPS) determine if they exhibit abnormal concentrations metabolites (e.g. those indicative heightened...
Psychological distress predicts the onset and worsening of persistent pain, but mechanisms that underpin this influence are poorly understood. Pro-inflammatory signalling is a plausible mechanistic link, given its known connections to distress, neural upregulation. Sustained may prime inflammatory system respond more strongly phasic noxious challenge, supporting neuroimmune upregulation central nociceptive pain. This cross-sectional study tested hypotheses in vitro endotoxin-provoked...
An emerging concept in the chronic pain literature, high-impact (HICP), refers to that occurs very frequently and results major disruption of daily life. Previous epidemiologic investigations have noted lower educational attainment, age, race appear be associated with frequency HICP, but condition-specific HICP been less common. Here we investigate status its clinical/demographic correlates Multidisciplinary Approach study Pelvic Pain research network Symptom Pattern Study. Participants were...