A5073259849- Epilepsy research and treatment
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Fetal and Pediatric Neurological Disorders
- Glioma Diagnosis and Treatment
- Pharmacological Effects and Toxicity Studies
- Neurological disorders and treatments
- Neuroscience and Neuropharmacology Research
- EEG and Brain-Computer Interfaces
- Neonatal and fetal brain pathology
- Neurogenesis and neuroplasticity mechanisms
- Mitochondrial Function and Pathology
- Vascular Malformations Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Olfactory and Sensory Function Studies
- Intracerebral and Subarachnoid Hemorrhage Research
Fondazione IRCCS Istituto Neurologico Carlo Besta
2010-2018
Istituti di Ricovero e Cura a Carattere Scientifico
2018
Politecnico di Milano
2011
ABSTRACT Pre‐surgical and post‐surgical data were examined compared from 215 consecutive patients undergoing surgery for intractable epilepsy. Patients selected on the basis of a proven histopathological diagnosis type I focal cortical dysplasia (FCD I), alone or associated with other lesions. The divided into five sub‐groups: i) 66 isolated FCD I, ii) 76 hippocampal sclerosis, iii) 49 tumours, iv) 16 malformations development v) eight anoxic‐ischaemic inflammatory diseases. duration...
Magnetic resonance imaging-positive temporal lobe atrophy with temporo-polar grey/white matter abnormalities (usually called 'blurring') has been frequently reported in patients epilepsy associated hippocampal sclerosis. The poor distinction of grey and white attributed to various causes, including developmental cortical abnormalities, gliosis, myelin alterations, a non-specific increase water content metabolic/perfusion alterations. However, there is still no consensus regarding the genesis...
Hippocampal sclerosis (HS) is the most frequent neuropathologic finding in patients undergoing surgery for intractable temporal lobe epilepsy (TLE). The International League Against Epilepsy (ILAE) has recently proposed a new classification of HS based on specific patterns cell loss. aim this study was to investigate relationships between types, their etiologic factors, and short- long-term postsurgical outcomes because drug-resistant TLE with HS.Two hundred thirteen diagnosis minimum...
Summary Objective Hippocampal sclerosis ( HS ) is the major structural brain lesion in patients with temporal lobe epilepsy TLE ). However, its internal anatomic structure remains difficult to recognize at 1.5 or 3 Tesla T magnetic resonance imaging MRI ), which allows neither identification of specific pathology patterns nor their proposed value predict postsurgical outcome, cognitive impairment, underlying etiologies. We aimed identify subtypes resected surgical samples on 7 by...
In the present report, correlations between ex vivo high-resolution imaging and specific histological ultrastructural patterns in type II focal cortical dysplasia (FCD) have been studied to explain differences magnetic resonance (MRI) detection of contribute presurgical evaluation this pathology.Surgical specimens from 13 patients with FCD IIa/b were submitted 7T MRI scanning, then analyzed histologically ultrastructurally compare results findings. Region interest (ROI)-based measures on...
<h3>Objectives:</h3> The purpose of the study was to investigate abnormalities cortical lamination observed in temporal lobe specimens obtained during surgery for intractable epilepsy (TLE) with hippocampal sclerosis. Specifically, we aimed 1) correlate high-field ex vivo MRI histopathologic analysis and 2) evaluate effect tissue fixation on image contrast. <h3>Methods:</h3> A cohort 13 considered. T2-weighted imaging relaxometry were performed after using a 7-T experimental scanner. After...
Seizure patterns identified in focal epilepsies caused by diverse etiologies are likely due to different pathogenic mechanisms. We describe here a novel, region-specific seizure pattern that mimics activity observed subpopulation of patients submitted presurgical monitoring with intracerebral electrodes. Distinctive seizure-like events (SLEs) induced the olfactory regions acute treatment both tangential brain slices and isolated guinea pig potassium channel blocker 4-aminopyridine. Analysis...
Abstract During development, the hippocampus undergoes numerous changes in its cell morphology and cyto‐ myelo‐architecture that begin during fetal period continue after birth. We investigated developmental occurring healthy (20–32 gestational weeks) post‐natal human hippocampi (from 1 day to adulthood) by combining high‐resolution 7 T magnetic resonance imaging (MRI) histological immunohistochemical analyses order compare variations signal intensity with myeloarchitectural organization. of...