A5041366828- SARS-CoV-2 and COVID-19 Research
- Genetic and phenotypic traits in livestock
- COVID-19 Clinical Research Studies
- Coal and Its By-products
- Heme Oxygenase-1 and Carbon Monoxide
- Growth Hormone and Insulin-like Growth Factors
- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Wnt/β-catenin signaling in development and cancer
- Neonatal Health and Biochemistry
- Cancer-related molecular mechanisms research
- Geochemistry and Elemental Analysis
- Bacteriophages and microbial interactions
- Erythrocyte Function and Pathophysiology
- Virus-based gene therapy research
- Immune cells in cancer
- Retinal Development and Disorders
- Phagocytosis and Immune Regulation
- Cancer-related gene regulation
- Mosquito-borne diseases and control
- Coal Properties and Utilization
- Phytoestrogen effects and research
- Geological and Geochemical Analysis
- interferon and immune responses
- Geochemistry and Geologic Mapping
Sichuan University of Science and Engineering
2019-2025
Yibin University
2021-2025
Yale University
2009-2024
Anhui University of Science and Technology
2008-2023
Lanzhou University
2020-2022
Lanzhou University Second Hospital
2020-2022
Peking University
2022
Peking University Cancer Hospital
2022
Harbin Institute of Technology
2022
Bellevue College
2022
The loss of the SOST gene product sclerostin leads to sclerosteosis characterized by high bone mass. In this report, we found that could antagonize canonical Wnt signaling in human embryonic kidney A293T cells and mouse osteoblastic MC3T3 cells. This sclerostin-mediated antagonism be reversed overexpression co-receptor low density lipoprotein receptor-related protein (LRP) 5. addition, bound LRP5 as well LRP6 identified first two YWTD-EGF repeat domains being responsible for binding....
Abstract Summary: Biological sequence diagrams are fundamental for visualizing various functional elements in protein or nucleotide sequences that enable a summarization and presentation of existing information as well means intuitive new discoveries. Here, we present software package called illustrator biological (IBS) can be used representing the organization either convenient, efficient precise manner. Multiple options provided IBS, manipulated, recolored rescaled user-defined mode. Also,...
Small ubiquitin-like modifiers (SUMOs) regulate a variety of cellular processes through two distinct mechanisms, including covalent sumoylation and non-covalent SUMO interaction. The complexity regulations has greatly hampered the large-scale identification substrates or interaction partners on proteome-wide level. In this work, we developed new tool called GPS-SUMO for prediction both sites SUMO-interaction motifs (SIMs) in proteins. To obtain an accurate performance, generation group-based...
Abstract Recent studies implicate chromatin modifiers in autism spectrum disorder (ASD) through the identification of recurrent de novo loss function mutations affected individuals. ASD risk genes are co-expressed human midfetal cortex, suggesting that converge specific regulatory networks during neurodevelopment. To elucidate such networks, we identify targeted by CHD8, a chromodomain helicase strongly associated with ASD, brain, neural stem cells (hNSCs) and embryonic mouse cortex. CHD8...
The novel coronavirus pneumonia (COVID-19) is an infectious acute respiratory infection caused by the coronavirus. virus a positive-strand RNA with high homology to bat In this study, conserved domain analysis, modeling, and molecular docking were used compare biological roles of certain proteins results showed ORF8 surface glycoprotein could bind porphyrin, respectively. At same time, orf1ab, ORF10, ORF3a coordinate attack heme on 1-beta chain hemoglobin dissociate iron form porphyrin. will...
Recent evidence suggests that members of the Dickkopf (Dkk) family can directly bind to LDL-related protein (LRP)-6, resulting in inhibition Wnt-activated signaling. To further characterize interactions between Dkk and LRP proteins, conditioned media containing individually conserved cysteine-rich domains Dkk-1 Dkk-2 were prepared. Although full-length second both molecules inhibited Wnt-3a-induced activation lymphoid enhancing factor (LEF)-1, a downstream target canonical pathway, we found...
Abstract Contact lenses are increasingly used in laboratories for vivo animal retinal imaging and pre-clinical studies. The lens shapes often need modification to optimally fit corneas of individual test subjects. However, the choices from commercially available contact rather limited. Here, we report a flexible method fabricate customized hydrogel lenses. We showed that fabricated is highly transparent, with refractive indices ranging 1.42 1.45 spectra range 400 nm 800 nm. Young’s modulus...
<p>The novel coronavirus pneumonia (COVID-19) is an infectious acute respiratory caused by the coronavirus. The virus positive-strand RNA one with high homology to bat pathogenic mechanism of new still unclear, which a significant obstacle development drugs and patients' rescue. In this study, conserved domain analysis, modeling, molecular docking were made compare biological roles specific proteins belonging analysis showed envelope protein (E), nucleocapsid phosphoprotein (N) ORF3a...
The novel coronavirus pneumonia (COVID-19) is an infectious acute respiratory infection caused by the coronavirus. virus a positive-strand RNA with high homology to bat In this study, conserved domain analysis, modeling, and molecular docking were used compare biological roles of certain proteins results showed ORF8 surface glycoprotein could bind porphyrin, respectively. At same time, orf1ab, ORF10, ORF3a coordinate attack heme on 1-beta chain hemoglobin dissociate iron form porphyrin. will...
The novel coronavirus pneumonia (COVID-19) is an infectious acute respiratory caused by the coronavirus. virus a positive-strand RNA with high homology to bat In this study, conserved domain analysis, modeling, and molecular docking were used compare biological roles of specific proteins results showed that some viral structural nonstructural could bind porphyrin, respectively. At same time, orf1ab, ORF10 ORF3a coordinated attack heme on 1-beta chain hemoglobin, dissociating iron form...
The novel coronavirus pneumonia is a contagious acute respiratory disease caused by the SARS-COV-2 coronavirus. pathogenic mechanism of unknown, which presents significant impediment to patient rescue. A conserved domain search strategy was utilized in this work determine that large number viral proteins could bind hemoglobin. S extracellular virus interacted with porphyrins. viruses synthesize heme from porphobilinogen and encode all similar enzymes required for process. Both E ORF3a...
Currently, the novel coronavirus pneumonia has been widespread globally, and there is no specific medicine. In response to emergency, we employed bioinformatics methods investigate virus's pathogenic mechanism, finding possible control methods. We speculated in previous studies that E protein was associated with viral infectivity. The present study adopted domain search techniques analyse protein. According results, could bind iron or haem. haem bound by came from attacked haemoglobin...
The novel coronavirus pneumonia is a contagious acute respiratory disease caused by the SARS-COV-2 coronavirus. pathogenic mechanism of unknown, which presents significant impediment to patient rescue. A conserved domain search strategy was utilized in this work determine that large number viral proteins could bind hemoglobin. S extracellular virus interacted with porphyrins. viruses synthesize heme from porphobilinogen and encode all similar enzymes required for process. Both E ORF3a...
A rare mutation in LRP6 has been shown to underlie autosomal dominant coronary artery disease (CAD) and metabolic syndrome an Iranian kindred. The prevalence spectrum of mutations the population United States is not known. Two hundred white Americans with early onset familial CAD 2,000 healthy Northern European controls were screened for nonconservative LRP6. Three novel identified, which cosegregated traits kindreds affected subjects none controls. All three reside second propeller domain,...
The novel coronavirus pneumonia (COVID-19) is an infectious acute respiratory caused by the coronavirus. virus positive-strand RNA one with high homology to bat pathogenic mechanism of new still unclear, which a significant obstacle development drugs and patients' rescue. In this study, conserved domain analysis, modeling, molecular docking were made compare biological roles specific proteins belonging analysis showed envelope protein (E), nucleocapsid phosphoprotein (N) ORF3a had heme...
Investigating poor respiratory function and high immunological escape in COVID-19 patients may aid the prevention of additional deaths. The conserved domain search method was used to evaluate biological roles specific SARS-COV-2 proteins this present study. research findings indicate that virus contains domains capable binding porphyrin synthesizing heme. S ORF3a can bind hemoglobin. protein possesses hemocyanin-like since it copper-oxygen binding, agglutination, phenoloxidase domains....
Abstract Research demonstrates the important role of genetic factors in attention-deficit/hyperactivity disorder (ADHD). DNA sequencing families provides a powerful approach for identifying de novo (spontaneous) variants, leading to discovery hundreds clinically informative risk genes other childhood neurodevelopmental disorders. This has yet be extensively leveraged ADHD. We conduct whole-exome 152 families, comprising child with ADHD and both biological parents, demonstrate significant...
Background: Hantavirus illness is characterized by increased vascular permeability and hemorrhagic fever with renal syndrome or cardiopulmonary syndrome. Methods: In this study, the domain search approach, a bioinformatics method, was utilized to understand more about hantavirus E protein structures. Results: Activities of Ca2+ binding domain, C-type lectin, Dockerin, glycosyl hydrolase (cellulase), PI3K, threonine kinase, PTEN, GTPase, PPM, flippase, other domains were identified in...
Pre-trained large models attract widespread attention in recent years, but they face challenges applications that require high interpretability or have limited resources, such as physical sensing, medical imaging, and bioinformatics. Compressed Sensing (CS) is a well-proved theory drives many breakthroughs these applications. However, typical under-determined linear system, CS suffers from excessively long sparse reconstruction times when using traditional iterative methods, particularly...
Mutation in the EGFP domain of LDL receptor-related protein 6 (LRP6(R611C)) is associated with hypercholesterolemia and early-onset atherosclerosis, but mechanism by which it causes disease not known. Cholesterol uptake was examined cells from LRP6(+/-) mice LRP6(R611C) mutation carriers. Splenic B have significantly lower LRP6 expression low-density lipoprotein (LDL) than those wild-type littermates. Although similar levels total were found lymphoblastoid (LCLs) carriers unaffected family...