A5083942287- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- Genetics and Neurodevelopmental Disorders
- Epigenetics and DNA Methylation
- Glioma Diagnosis and Treatment
- Genetic Associations and Epidemiology
- Single-cell and spatial transcriptomics
- Mitochondrial Function and Pathology
- Cancer Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Health, Environment, Cognitive Aging
- CNS Lymphoma Diagnosis and Treatment
- Genomics and Rare Diseases
- Brain Metastases and Treatment
- Machine Learning in Bioinformatics
- Retinal Development and Disorders
- Immunotherapy and Immune Responses
- Genomics and Chromatin Dynamics
- Advanced Biosensing Techniques and Applications
Yale University
2018-2021
INTRODUCTION The brain is responsible for cognition, behavior, and much of what makes us uniquely human. development the a highly complex process, this process reliant on precise regulation molecular cellular events grounded in spatiotemporal transcriptome. Disruption can lead to neuropsychiatric disorders. RATIONALE regulatory, epigenomic, transcriptomic features human have not been comprehensively compiled across time, regions, or cell types. Understanding etiology disorders requires...
Abstract Transcriptome-wide association analysis is a powerful approach to studying the genetic architecture of complex traits. A key component this build model predict (impute) gene expression levels from genotypes samples with matched and in specific tissue. However, it challenging develop robust accurate imputation models limited sample sizes for any single Here, we first introduce multi-task learning jointly impute 44 human tissues. Compared single-tissue methods, our achieved an average...
Abstract The similarities and differences between nervous systems of various species result from developmental constraints specific adaptations 1-4 . Comparative analyses the prefrontal cortex (PFC), a region cerebral involved in higher-order cognition complex social behaviors, have identified confirmed putative human-specific structural molecular changes 4-8 For example, one crucial specialization involves anterior-posterior gradient synaptic density, with disproportionately higher number...
Despite the findings in genome-wide association studies (GWASs) for late-onset Alzheimer's disease (LOAD), our understanding of its genetic architecture is far from complete. Transcriptome-wide analysis that integrates GWAS data with large-scale transcriptomic databases a powerful method to study complex traits' architecture. It challenging effectively utilize information given limited and unbalanced sample sizes different tissues. Here we introduce apply novel perform statistically...