A5031539946- Single-cell and spatial transcriptomics
- Conducting polymers and applications
- Perovskite Materials and Applications
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Random Matrices and Applications
- Genetic Associations and Epidemiology
- RNA modifications and cancer
- Gene Regulatory Network Analysis
- Nonlinear Dynamics and Pattern Formation
- Advanced Memory and Neural Computing
- Semiconductor materials and devices
- Stochastic processes and statistical mechanics
- Aluminum Alloys Composites Properties
- Genomics and Chromatin Dynamics
- Ferroelectric and Negative Capacitance Devices
- Organic Electronics and Photovoltaics
- Aluminum Alloy Microstructure Properties
- Advanced Algebra and Geometry
- Mathematical Dynamics and Fractals
- RNA and protein synthesis mechanisms
- Psychosocial Factors Impacting Youth
- Education and Learning Interventions
- Quantum Dots Synthesis And Properties
- Genomics and Rare Diseases
Samsung (South Korea)
2023-2024
Sungkyunkwan University
2022-2024
Icahn School of Medicine at Mount Sinai
2023
The University of Tokyo
2022
Yale University
2015-2021
Pusan National University
2009-2021
Kavli Institute for Theoretical Sciences
2019
University of Florida
2009-2010
INTRODUCTION The brain is responsible for cognition, behavior, and much of what makes us uniquely human. development the a highly complex process, this process reliant on precise regulation molecular cellular events grounded in spatiotemporal transcriptome. Disruption can lead to neuropsychiatric disorders. RATIONALE regulatory, epigenomic, transcriptomic features human have not been comprehensively compiled across time, regions, or cell types. Understanding etiology disorders requires...
Genes implicated in neuropsychiatric disorders are active human fetal brain, yet difficult to study a longitudinal fashion. We demonstrate that organoids from pluripotent cells model cerebral cortical development on the molecular level before 16 weeks postconception. A multiomics analysis revealed differentially genes and enhancers, with greatest changes occurring at transition stem progenitors. Networks of converging gene enhancer modules were assembled into six four global patterns...
The hippocampal-entorhinal system supports cognitive functions, has lifelong neurogenic capabilities in many species, and is selectively vulnerable to Alzheimer's disease. To investigate potential cellular diversity, we profiled single-nucleus transcriptomes five subregions humans, macaques, pigs. Integrated cross-species analysis revealed robust transcriptomic histologic signatures of neurogenesis the adult mouse, pig, macaque but not humans. Doublecortin (DCX), a widely accepted marker...
Gene expression levels vary across developmental stage, cell type, and region in the brain. Genomic variants also contribute to variation expression, some neuropsychiatric disorder loci may exert their effects through this mechanism. To investigate these relationships, we present BrainVar, a unique resource of paired whole-genome bulk tissue RNA sequencing from dorsolateral prefrontal cortex 176 individuals prenatal postnatal development. Here identify common that alter gene (expression...
Abstract Mechanically resilient optoelectronic devices are relevant for a wide range of applications, including portable and wearable devices. Perovskite thin film‐based suitable choice designing such systems as it demonstrates high performance while preserving moderate mechanical compliance. Yet its property can be improved further by integrating the energy dissipation system self‐healing ability into film. Copolymers containing Lewis‐base functional groups, elastomer chains, cyclic...
Abstract Dithiocarbonate‐based non‐hygroscopic polymers with a glass transition temperature ( T g ) and polydispersity index (PDI) of ≈4 °C 1, respectively, are synthesized through living cationic ring‐opening polymerization. These liquid‐state characterized by monodispersity based on the low PDI, rendering remarkable miscibility perovskite precursors without aggregation. Accordingly, these added to solar cells (PSCs) enhance their power conversion efficiency (PCE). The PCE reference PSCs...
Abstract This review addresses the self‐healing effects in perovskite solar cells (PSCs), emphasizing significance of chemical and physical bonding as core mechanisms. Polymeric additives play a vital role inducing phenomena along with intrinsic properties materials, both which are discussed herein. As relatively underexplored area, effect induced by polymeric PSCs is reviewed from perspective. The bonds involved include isocyanate, disulfide, carboxylic acid groups. related to primarily...
Abstract Nanocarbon materials, such as graphene and carbon nanotubes (CNTs), have attracted considerable attention the main or supplementary components in various optoelectronics boosting device performance improving process conditions. Specifically, their application to perovskite solar cells, which are among most promising photovoltaic devices acknowledged for eco‐friendly energy generation, has significantly impacted current standing of metal halide perovskite‐based devices. The...
The mechanisms whereby immune therapies affect progression of type 1 diabetes (T1D) are not well understood. Teplizumab, an FcR nonbinding anti‐CD3 mAb, has shown efficacy in multiple randomized clinical trials. We previously reported increase the frequency circulating CD8 + central memory (CD8CM) T cells responders, but generalizability this finding and molecular effects teplizumab on these have been evaluated. analyzed data from two studies patients with new‐ recent‐onset T1D. At...
Abstract Twenty-five participants listened to 8 radio messages—half of which were greater in auditory structural complexity. Physiological measures taken during message presentation, and self-report after each. Results show that increased complexity led higher self-reported physiological arousal, better attitudes toward the messages overall their nonclaim components. There no differences claims made at each level Structurally complex also freely recalled more often than simple messages. The...
This study pioneers a chemical sensor based on surfactant-free aerosol-synthesized single-walled carbon nanotube (SWCNT) films for detecting nitrogen dioxide (NO
SUMMARY The hippocampal-entorhinal system is comprised of functionally distinct subregions collectively critical for cognition, and selectively vulnerable to aging pathological processes. To gain insights into neuronal non-neuronal populations within this system, we performed single-nucleus transcriptional profiling from five human subregions. We found that transcriptomic diversity excitatory neurons across these reflected the molecular transition three-layered archicortex six-layered...
Using robust, integrated analysis of multiple genomic datasets, we show that genes depleted for non-synonymous de novo mutations form a subnetwork 72 members under strong selective constraint. We further this is preferentially expressed in the early development human hippocampus and enriched mutated neurological Mendelian disorders. thus conclude carefully orchestrated developmental processes are constraint brain development, perturbations caused by mutation have adverse outcomes subject to...
Perovskite solar cells (PSCs) are regarded as the next-generation thin-film energy harvester, owing to their high performance. However, there is a lack of studies on encapsulation technology, which critical for resolving shortcomings, such degradation by oxygen and moisture. It determined that moisture intrusion heat trapped within encapsulating cover glass PSCs influenced operating stability devices. Therefore, we improved barrier ability releasing capability in passivation adding...
Passivation films, commonly referred to as solid–electrolyte interphase and cathode–electrolyte (CEI), are essential for the operation of rechargeable batteries due their positive impact on electrochemical performances. This paper reports a bifunctional Al2O3 artificial layer LiNiO2 (LNO) cathode high-energy-density aqueous Li-ion (ALIBs). As determined by first-principles density functional theory calculations, has relatively high adsorption energy with H2O molecules at surface, which is...
We introduce a family of rotationally invariant random matrix ensembles characterized by parameter λ. While λ = 1 corresponds to well-known critical ensembles, we show that ≠ describes 'Lévy-like' power-law eigenvalue densities. For > the density is bounded, as in Gaussian but < densities with long tails. In particular, model allows us evaluate, terms novel orthogonal polynomials, correlations for Lévy-like ensembles. These differ qualitatively from those either or
Recently we introduced a family of $U(N)$ invariant Random Matrix Ensembles which is characterized by parameter $\lambda$ describing logarithmic soft-confinement potentials $V(H) \sim [\ln H]^{(1+\lambda)} \:(\lambda>0$). We showed that can study eigenvalue correlations these "$\lambda$-ensembles" based on the numerical construction corresponding orthogonal polynomials with respect to weight function $\exp[- (\ln x)^{1+\lambda}]$. In this work, expand our previous work and show that: i)...
Summary Variation in gene expression underlies neurotypical development, while genomic variants contribute to neuropsychiatric disorders. BrainVar is a unique resource of paired whole-genome sequencing and bulk-tissue RNA-sequencing from the human dorsolateral prefrontal cortex 176 individuals across prenatal postnatal providing opportunity assay transcriptomic variation tandem. Leveraging this resource, we identified rare premature stop codons with commensurate reduced allele-specific...
Abstract Single-walled carbon nanotubes (SWCNTs) are representative one-dimensional materials that show exceptional optical and electronic properties with various tuneable bandgaps. SWCNTs can be integrated into a variety of photovoltaics particularly, perovskite solar cells (PSCs) based on high level functionality purity. In this topical review, we discuss the fundamentals applied to PSCs as an electron-transporting layer, hole-transporting photoactive interfacial from literature. Firstly,...
Abstract This study presents an acetylene gas sensor capable of in situ monitoring transformer oils. utilizes carbon nanotubes (CNTs) embedded polyimide (PI) synthesized by floating catalyst chemical vapor deposition. Unlike conventional sensors that target hydrocarbon gases dissolved oil and measure the extracted from oil, proposed CNT‐PI detects within real time. The PI embedding technique effectively anchors shields CNT network against fluidic damage, ensuring stable sensing performance...
Abstract Spatially resolved transcriptomics (SRT) have enabled profiling spatial organization of cells and their transcriptome in situ. Various analytical methods been developed to uncover cell-cell interaction processes using SRT data. To improve upon existing efforts, we a novel statistical framework called QuadST for the robust powerful identification interaction-changed genes (ICGs) cell-type-pair specific interactions on single-cell dataset. is motivated by idea that presence...