A5103052346- Malaria Research and Control
- Mosquito-borne diseases and control
- Insect Resistance and Genetics
- Ideological and Political Education
- Computational Drug Discovery Methods
- Global Maternal and Child Health
- Parasite Biology and Host Interactions
- Viral Infections and Vectors
- Congenital Anomalies and Fetal Surgery
- Vector-borne infectious diseases
- Insect Pest Control Strategies
- Zoonotic diseases and public health
- Parasitic infections in humans and animals
- Parasites and Host Interactions
- Trypanosoma species research and implications
- Educational Strategies and Epistemologies
- Aquaculture disease management and microbiota
- Amoebic Infections and Treatments
- Hepatitis Viruses Studies and Epidemiology
- Education and Critical Thinking Development
- Immune responses and vaccinations
- Climate Change, Adaptation, Migration
- Social Capital and Networks
- Chemical Safety and Risk Management
- vaccines and immunoinformatics approaches
National Institute for Parasitic Diseases
2009-2024
Shanghai Jiao Tong University
2020-2024
Fujian Medical University
2024
Union Hospital
2024
Panzhihua University
2023
Putian University
2019
Chinese Center For Disease Control and Prevention
2008-2018
Zhejiang Academy of Medical Sciences
2017
Beijing Jiaotong University
2014
Fujian Jiangxia University
2010
Anopheles sinensis is the most important vector of malaria in Southeast Asia, including China. Currently, effective measure to prevent transmission relies on control through use insecticides, primarily pyrethroids. Extensive insecticides poses strong selection pressure mosquito populations for resistance. Resistance can arise due mutations insecticide target site (target resistance), which case pyrethroids para-type sodium channel gene, and/or catabolism by detoxification enzymes before it...
In the past decade, developing countries have been experiencing rapid land use and cover changes, including deforestation cultivation of previously forested land. However, little is known about impact land-use changes on life history malaria vectors their effects transmission. This study examined crop adult survivorship major mosquitoes, Anopheles sinensis An. minimus in China-Myanmar border region. We three conditions: indoor, forested, banana plantation. Mean survival time plantation...
Background Babesia is a unique apicomplexan parasite that specifically invades and proliferates in red blood cells can be transmitted via transfusion, resulting transfusion-transmitted babesiosis. However, detecting before transfusion has not received enough attention, the risk of transfusing containing low density microti ( B. ) unclear, possibly threatening public health wellness. Purpose This study aimed to determine lower detection limit evaluate transmission low-density . Methods...
Abstract Background Artemisinin and its derivatives have been used for falciparum malaria treatment in China since late 1970s. Monotherapy uncontrolled use of artemisinin drugs were common practices a long period time. In vitro tests showed that the susceptibility Plasmodium to artemisinins was declining China. A concern raised about resistance country. It has reported associated with S769N mutation PfATPase6 gene. The main purpose this study investigate whether occurred field isolates from...
Objective To ascertain the trends and burden of malaria in China costs interventions for 2011-2015.Methods We analysed spatiotemporal demographic features locally transmitted imported cases using disaggregated surveillance data on from 2011 to 2015, covering range dominant vectors China.The total mean elimination were calculated by funding sources, population at risk.Findings A 17 745 cases, including 123 deaths (0.7%), reported mainland China, with 15 840 (89%) being mainly Africa...
Abstract Background Insecticide resistance monitoring in malaria mosquitoes is essential for guiding the rational use of insecticides vector control programs. Resistance bioassay first step insecticide and it lays an important foundation molecular examination mechanisms. In literature, various mosquito sample collection preparation methods have been used, but how affect susceptibility results largely unknown. The objectives this study were to determine whether affected results, which may...
Drug resistance in Plasmodium falciparum is a serious public health threat the countries where this organism endemic. Since has been associated with specific single-nucleotide polymorphisms (SNPs) parasite genes, molecular markers are becoming useful surrogates for monitoring emergence and dispersion of drug resistance. In study, multiplex PCR (mPCR) oligonucleotide microarray method was developed detection these SNPs genes encoding chloroquine transporter (Pfcrt), multidrug 1 (Pfmdr1),...
To prioritize the introducing of new vaccines into China's National Immunization Program (NIP) among 10 candidate across four classes. We developed a vaccine value framework using Multi-Criteria Decision Analysis (MCDA) to simulate introduction NIP, covering 21 criteria encompassing six dimensions: safety, effectiveness, economy, innovation, accessibility, and appropriateness. Two decision scenarios were considered: Scenario One prioritized classes vaccines, while identified specific within...
BACKGROUND The role of the ubiquitin-specific peptidase 9 X-linked (USP9X) gene in breast cancer remains poorly understood. This study aimed to investigate USP9X tissue and cell lines. MATERIAL AND METHODS Immunohistochemistry was used examine expression levels 102 samples 41 normal samples. Overexpression MCF-7 MDA-MB-231 lines were studied by lentivirus vector transfection. Clustered regularly interspaced short palindromic repeats (CRISPR)/caspase-9 knockout performed. Cell proliferation,...
In China, Chloroquine (CQ) and sulfadoxine-pyrimethamine (SP) were abandoned for the treatment of falciparum malaria 20 years ago due to resistance. Subsequent field studies showed a trend declining CQ SP resistance in country. The main purpose this study was analyse molecular markers antimalarial thereby assess possibility reintroduction or treatment.Plasmodium isolates collected 2006-2007 from Hainan Yunnan provinces, China. Nested PCR-sequencing assays applied SNPs four genes: P....
Abstract Echinococcosis is endemic in pastoral regions of south, west and mid-Gansu province, China. The present study aimed to determine the prevalence echinococcosis east Gansu, analyze its associated risk factors. A cross-sectional survey was conducted 2011 12 villages Xiaonangou township, Huan County Gansu province by ultrasound abdominal scan auxiliary serotest, a surveillance from 2008 2014 performed one ultrasonography screening. Questionnaire information analysis indicates that...
CRISPR/Cas system, an adaptive immune system with clustered regularly interspaced short palindromic repeats, may interfere exogenous nucleic acids and protect prokaryotes from external damages, is effective gene editing acid detection tools. The has been widely applied in virology bacteriology; however, there relatively less knowledge about the application of parasitic diseases. review summarizes mechanisms action provides a comprehensive overview their diseases, so as to provide insights...
Purpose. The current study quantitatively assessed research trends in tropical medicine China via a bibliometric method, which used the Web of Science database to analyse research-based literature related published from 2010 2019. Methods. Articles were analysed according output and performance institutes countries that collaborated with China. Distribution keywords was applied evaluate trends. Results. Our findings showed 3372 articles field have been indexed under during past 10 years,...
Objective To investigate the pyrethroid resistance in malarial vector Anopheles sinensis and association with kdr mutation. Methods The insecticide impregnated papers contact method recommended by WHO was used to observe knockdown rate mortality of Anopheles, Leu-Phc mutation sodium channel gene detected polymerase chain reaction sequencing. Results Insecticide susceptibility bioassay results showed that mortalities from all three localities were lower than 95% on both deltamethrin...
Abstract Background Many valuable and productive patented technologies have been developed to control schistosomiasis in China the past 70 years. We conducted a research analyse for prevention filed by Chinese applicants determining future patent layout. Methods The databases of National Intellectual Property Administration Baiten were comprehensively searched, prevention, published between January 1950 December 2020 sorted on 30 2020. types, technical fields, development trends analysed...
By reviewing the relevant theories, definition and research object of safety occupational aptitude has been cleared.By introducing competency theory in human resource management into drawing reference from establishment inspection method model, this paper provides a new theoretical basis for establishing special industry model.
To evaluate the risk assessment model of Cryptosporidium laboratory, so as to provide basis for laboratory personnel engaging in operation Cryptosporidium.Firstly, factors infection were determined by literature and Delphi, then weights fuzzy analytic hierarchy process. A biosafety was established.Compared indexes, based on model, stool sample processing two steps with high factors, combination possibility hazard rating 0.111 0.107, respectively.The established is feasible. It can be used...