A5100702074- Catalysis and Oxidation Reactions
- Topological Materials and Phenomena
- Catalysts for Methane Reforming
- Catalytic Processes in Materials Science
- CRISPR and Genetic Engineering
- Bacteriophages and microbial interactions
- Sports injuries and prevention
- Shoulder Injury and Treatment
- Genomics and Phylogenetic Studies
- Single-cell and spatial transcriptomics
- Graphene research and applications
- Tendon Structure and Treatment
- Advanced biosensing and bioanalysis techniques
- Bacterial Genetics and Biotechnology
- RNA and protein synthesis mechanisms
- 2D Materials and Applications
- Evaluation Methods in Various Fields
- Galectins and Cancer Biology
- Multimodal Machine Learning Applications
- Inflammasome and immune disorders
- Advanced oxidation water treatment
- Global Health Care Issues
- IL-33, ST2, and ILC Pathways
- Magnetic properties of thin films
- Ideological and Political Education
ShanghaiTech University
2022-2025
Nanyang Technological University
2024-2025
State Key Laboratory of Nonferrous Metals and Processes
2024-2025
General Research Institute for Nonferrous Metals (China)
2024-2025
Suzhou Municipal Hospital
2024
Central South University
2024
Australian National University
2024
Nanjing Medical University
2024
Shanghai Children's Hospital
2024
Shanghai Jiao Tong University
2024
The National Genomics Data Center (NGDC), part of the China for Bioinformation (CNCB), provides a family database resources to support global research in both academia and industry. With explosively accumulated multi-omics data at ever-faster rates, CNCB-NGDC is constantly scaling up updating its core through big archive, curation, integration analysis. In past year, efforts have been made synthesize growing knowledge, particularly single-cell omics precision medicine research, series newly...
ABSTRACT α‐Synuclein (α‐syn) forms structurally distinct fibril polymorphs with various pathological activities in different subtypes of synucleinopathies, such as Parkinson's disease (PD). As a unique proteinaceous polymer, the mechanical property α‐syn is primary determinant its neurotoxicity, immunogenicity, and seeding transmission capacity. Nevertheless, how genetic mutations fibrils cause varied polymer behaviors remains largely unknown. Using optical tweezers, we quantitatively...
Paraffin wax (PW) has significant potential for spacecraft thermal management, but low conductivity and leakage issues make it no longer sufficient the requirements of evolving control systems. Although free-state expanded graphite (EG) as a enhancer can ameliorate above problems, remains challenging to achieve higher (K) (>8 W/(m·K)) at filler contents below 10 wt.% mitigate problem. Two preparations thermally conductive shape-stabilized PW/EG composites, using pressure-induced method...
Recently, promising progress has been made by open-source vision-language models (VLMs) in bringing their capabilities closer to those of proprietary frontier models. However, most only publish final model weights, leaving the critical details data strategies and implementation largely opaque. In this work, we address VLM post-training from a data-centric perspective, showing key role strategy developing VLMs. By studying building our scratch, share detailed insights into development...
Chirality or handedness manifests in all fields of science, ranging from cell biology, molecular interaction, and catalysis to different branches physics. In condensed matter physics, chirality is intrinsic enigmatic quantum phases, such as chiral charge density waves superconductivity. Here, the underlying response subtle leads broken symmetries ground state. Detection key understand these states but they are extremely challenging expose leading debate controversy. using second-order...
Abstract The tripartite ParABS system mediates chromosome segregation in a wide range of bacteria. Dimeric ParB was proposed to nucleate on parS sites and spread neighboring DNA. However, how properly distributed dimers further compact chromosomal DNA into higher-order nucleoprotein complex for partitioning remains poorly understood. Here, using single-molecule approach, we show that tens Bacillus subtilis (Spo0J) proteins can stochastically multimerize stably bind nonspecific introduction...
Abstract The tripartite ParABS system mediates chromosome segregation in the majority of bacterial species. Typically, DNA-bound ParB proteins around parS sites condense chromosomal DNA into a higher-order multimeric nucleoprotein complex for ParA-driven partition. Despite extensive studies, molecular mechanism underlying dynamic assembly partition remains unclear. Herein, we demonstrate that Bacillus subtilis (Spo0J), through multimerization its N-terminal domain, forms phase-separated...
Abstract Type V-F CRISPR-Cas12f is a group of hypercompact RNA-guided nucleases that present versatile in vivo delivery platform for gene therapy. Upon target recognition, Acidibacillus sulfuroxidans Cas12f (AsCas12f1) distinctively engenders three DNA break sites, two which are located outside the protospacer. Combining ensemble and single-molecule approaches, we elucidate molecular details underlying AsCas12f1-mediated cleavages. We find following protospacer unwinding non-target strand...
Abstract The purpose of this study was to investigate differences in ankle plantar flexion proprioception and lower extremity function between Achilles tendinopathy (AT) patients healthy controls. 17 with midportion AT (age 22.0 ± 3.0, 7 females, 10 males) controls 21.5 2.1, were recruited. following tests performed randomly: the active movement extent discrimination assessment (AMEDA), weight‐bearing lunge test (WBLT), single leg hop test, figure‐of‐eight Y Balance Test (YBT), functional...
A topological insulator is a quantum material which possesses conducting surfaces and an insulating bulk. Despite extensive researches on the properties of Dirac surface states, characteristics bulk states have remained largely unexplored. Here we report observation spinor-dominated magnetoresistance anomalies in β-Ag2Se, induced by magnetic-field-driven band phase transition. These are caused intrinsic orthogonality wave-function spinors last Landau bands backscattering strictly forbidden...
(1) Background: The role of radiotherapy (RT) in superficial esophageal squamous cell cancer (ESCC) remains unclear. objective our study was to perform a detailed outcome and safety analysis RT as definitive or adjuvant treatment for T1N0M0 staged ESCC patients. (2) Methods: A total 55 patients treated with endoscopic resection (ER) + RT/concurrent chemoradiotherapy (CCRT) RT/CCRT from January 2011 June 2021 were included this study. Eighteen risk factors received ER RT/CCRT, thirty-seven...
Centralized photovoltaic power station is an important part of building a new system, whose generation unit the main equipment station. Therefore, it basis analyzing harmonic characteristics to study mechanism and influencing factors units establish equivalent model units. In this paper, firstly, analyzed from aspects sinusoidal pulse width modulation (SPWM) dead time inverter. Secondly, correlation analysis output carried out, then influence on harmonics analyzed. Thirdly, characteristic...
Abstract G‐quadruplex (G4) is a four‐stranded noncanonical DNA structure that has long been recognized as potential hindrance to replication. However, how replisomes effectively deal with G4s avoid replication failure still obscure. Here, using single‐molecule and ensemble approaches, the consequence of collision between bacteriophage T7 replisome an intramolecular G4 located on either leading or lagging strand examined. It found adjacent fork junctions induced by formation incur binding...
Abstract Objectives By measuring the cost of basic public health service projects in township centres Guangxi, it provides a reference for improving practical test theoretical system equivalence method, saving projects, and efficiency quality services provided by medical personnel. Methods We used multi-stage stratified sampling method to select 50 from Guangxi province, China. The was measured equivalent through field research data collection. Results In 2020, carried out 71 primary care 5...
In this article, AlSi10Mg aluminum alloy was used as the substrate to prepare alloy/diamond composite materials with laser cladding technology. The effects of composition and power on microstructure thermal properties were studied. results show that prefabrication tungsten carbide layer diamond surface enhances wettability reduces reflection, which ensures implementability technology for preparation composites. components determine temperature molten pool thus state organization material be...
Pyroptosis has attracted attention due to its role in various cancers. Recently, gasdermins (GSDMs) involved pyroptosis have been reported be associated with several types of However, the GSDMs expression diagnosis and prognosis gastric cancer (GC) is still not well understood. We analyzed transcriptional prognostic information patients GC from TIMER, UALCAN, Human Protein Atlas (HPA), GEPIA, Kaplan-Meier Plotter databases. The cBioPortal platform was used discover genetic alterations,...
Proprioception plays an important role in joint stability, and ankle sprains usually happen involving plantarflexion, internal rotation, inversion. However, 3D movement proprioception has never been measured weight-bearing. Accordingly, the active 3-dimensional extent discrimination apparatus (AMEDA-3D) was developed its reliability validity were investigated. A total of 58 subjects volunteered for this trial, with 12 chronic instability (CAI) healthy controls test-retest study. There 17 CAI...
ObjectiveOxygen and hemodynamic management are important for providing a sufficient adequate oxygen-containing blood to the organs septic patients. In present study, we aimed explore application of sequential respiratory support (SRS) association SRS with outcome patients who needed continuous renal replacement therapy (CRRT).MethodsWe extracted medical information received CRRT within 24 h intensive care unit (ICU) admission from MIMIC-III v1.4. was defined as receiving firstly oxygen...