A5076644364- Advanced biosensing and bioanalysis techniques
- CRISPR and Genetic Engineering
- RNA Interference and Gene Delivery
- Phytochemicals and Antioxidant Activities
- RNA and protein synthesis mechanisms
- Biosensors and Analytical Detection
- Reproductive System and Pregnancy
- Food Quality and Safety Studies
- Body Composition Measurement Techniques
- Advanced Glycation End Products research
- Nutritional Studies and Diet
- Botanical Research and Applications
- Soil and Unsaturated Flow
- Soil erosion and sediment transport
- Reproductive Physiology in Livestock
- Radical Photochemical Reactions
- DNA and Nucleic Acid Chemistry
- Microbial Community Ecology and Physiology
- Climate change impacts on agriculture
- Advancements in Battery Materials
- CO2 Reduction Techniques and Catalysts
- Cardiovascular Disease and Adiposity
- Anodic Oxide Films and Nanostructures
- Ovarian function and disorders
- Alcohol Consumption and Health Effects
Shanghai Institute of Microsystem and Information Technology
2023-2025
ShanghaiTech University
2021-2024
University of Science and Technology of China
2024
Nanjing University
2024
Huazhong Agricultural University
2024
Eye & ENT Hospital of Fudan University
2024
State Key Laboratory of Medical Neurobiology
2024
Hefei National Center for Physical Sciences at Nanoscale
2024
Peking University
2024
Peking University Third Hospital
2024
The development of a reliable strategy for stereodivergent radical reactions that allows convenient access to all stereoisomers homocoupling adducts with multiple stereogenic centers remains an unmet goal in organic synthesis. Herein, we describe dual-catalyzed electrooxidative C(sp3)–H/C(sp3)–H complete absolute and relative stereocontrol the synthesis molecules contiguous quaternary stereocenters general predictable manner. reaction is achieved by synergistically utilizing two distinct...
The exploitation of carbon dioxide (CO2) as a sustainable, plentiful, and harmless C1 source for the catalytic synthesis enantioenriched carboxylic acids has long been acknowledged pivotal task in synthetic chemistry. Herein, we present current-driven nickel-catalyzed reductive carboxylation reaction with CO2 fixation, facilitating formation C(sp3)–C(sp2) bonds by circumventing handling moisture-sensitive organometallic reagents. This electroreductive protocol serves practical platform,...
Abstract Aims To investigate the associations of conicity index (C‐index) and relative fat mass (RFM) with incident type 2 diabetes mellitus (T2DM) among adults in China. Materials Methods A total 10 813 participants aged over 18 years Shenzhen Longhua district were enrolled a follow‐up study conducted from 2018 to 2022. The categorized based on quartiles (Q) C‐index RFM. Cox proportional hazards model was performed examine relationships between C‐index, RFM risk T2DM. Results After...
The relationship between specific dietary patterns and diversity with cognitive frailty continues to be a subject of ambiguity.This research revealed that regular consumption fruit, meat, bean products, garlic, tea was connected decreased risk frailty. Compared participants score (DDS) ≤6 points, those DDS 9-10, 11-12, ≥12 had lower frailty.The results the study corroborate augmented frequency tea, in conjunction an elevated DDS, increased developing
Abstract Streptococcus pyogenes Cas9 (SpCas9), a programmable RNA-guided DNA endonuclease, has been widely repurposed for biological and medical applications. Critical interactions between SpCas9 confer the high specificity of enzyme in genome engineering. Here, we unveil that an essential SpCas9–DNA interaction located beyond protospacer adjacent motif (PAM) is realized through electrostatic forces four positively charged lysines among residues 1151–1156 negatively backbone. Modulating this...
Abstract Glucose is critical during early pregnancy. The uterus can store glucose as glycogen but uterine metabolism poorly understood. This study analyzed storage and localization of metabolizing enzymes from proestrus until implantation in the murine uterus. Quantification diastase‐labile periodic acid–Schiff (PAS) staining showed glandular epithelium decreased 71.4% at 1.5 days postcoitum (DPC) 62.13% DPC 3.5 compared to proestrus. In luminal epithelium, was highest proestrus, 46.2% 63.2%...
Single-stranded guanine-rich RNA sequences have a propensity to fold into compact G-quadruplexes (RG4s). The conformational transitions of these molecules provide an important way regulate their biological functions. Here, we examined the stability and conformation RG4-forming sequence identified near end human telomerase RNA. We found that proximal single-stranded (ss) significantly impairs RG4 at physiological K+ concentrations, resulting in reduced rupture force ∼ 24.4 pN easier...
Approximately 50% of pregnancies in humans fail, mostly before or during implantation. One factor contributing to pregnancy loss is abnormal glucose metabolism the endometrium. Glucose contributes preimplantation embryo development, uterine receptivity, and attachment embryo. Across multiple species, epithelium stores as macromolecule glycogen at estrus. This reserve mobilized period. from circulation glycogenolysis can be secreted into lumen for use by metabolized via glycolysis, producing...
The advanced glycation end products (AGEs) are formed in baked through the Maillard reaction (MR), which thought to be a contributing factor chronic diseases such as heart and diabetes. Lotus seedpod oligomeric procyanidins (LSOPC) natural antioxidants that have been added tough biscuit create functional foods may lower risk of diseases. effect LSOPC on AGEs formation sensory quality were examined this study. With addition LSOPC, scavenging rate antioxidant capacity LSOPC-added biscuits...
Red guava, distinguished by its elevated lycopene content, emerges as a promising natural source of carotenoids. This study systematically evaluates the impact diverse processing techniques on efficient release The primary objective is to facilitate transfer carotenoids into juice fraction, yielding carotenoid-enriched seamlessly integrable aqueous-based food matrices. untreated guava puree exhibited modest carotenoids, with only 66.26% β-carotene and 57.08% reaching juice. Contrastly, both...
Abstract Type V-F CRISPR-Cas12f is a group of hypercompact RNA-guided nucleases that present versatile in vivo delivery platform for gene therapy. Upon target recognition, Acidibacillus sulfuroxidans Cas12f (AsCas12f1) distinctively engenders three DNA break sites, two which are located outside the protospacer. Combining ensemble and single-molecule approaches, we elucidate molecular details underlying AsCas12f1-mediated cleavages. We find following protospacer unwinding non-target strand...
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder characterized by hormonal imbalances and insulin resistance (IR). Among the metabolic abnormalities associated with PCOS, obesity often present concurrently. Nevertheless, correlation between obesity, sex hormone levels, blood lipid profiles in PCOS patients IR remains uncertain.
Extreme drought events during spring have been predicted to increase and can profoundly threaten the grassland ecosystem through influencing early growing season stages. However, whether these impacts are recoverable still remain controversial, role of degradation status is also unclear. By selecting three fields with different levels (extreme, moderate, light degradation) on a Leymus chinensis steppe in Northern China, we conducted simulated extreme experiment late (mid-May mid-June) using...
Cas9 is an RNA-guided endonuclease from the type II CRISPR-Cas system that employs RNA-DNA base pairing to target and cleave foreign DNA in bacteria. Due its robust programmable activity, has been repurposed as a revolutionary technology for wide-ranging biological medical applications. A comprehensive understanding of mechanisms at molecular level would aid better usage genome tool. Over past few years, single-molecule techniques, such fluorescence resonance energy transfer, curtains,...