A5059718939- Alzheimer's disease research and treatments
- Bioinformatics and Genomic Networks
- Genetically Modified Organisms Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Turfgrass Adaptation and Management
- Glutathione Transferases and Polymorphisms
- Genomics and Phylogenetic Studies
- Computational Drug Discovery Methods
- Genetics and Neurodevelopmental Disorders
- Tryptophan and brain disorders
- Immune Cell Function and Interaction
- Dementia and Cognitive Impairment Research
- Genetics, Aging, and Longevity in Model Organisms
- 3D Printing in Biomedical Research
- Neurological diseases and metabolism
- Horticultural and Viticultural Research
- Machine Learning in Bioinformatics
- Genomics and Rare Diseases
- CRISPR and Genetic Engineering
- Molecular Biology Techniques and Applications
- Genetic Associations and Epidemiology
- RNA and protein synthesis mechanisms
- Ferroptosis and cancer prognosis
- Plant Physiology and Cultivation Studies
- Immune Response and Inflammation
Chinese Academy of Sciences
2014-2017
Beijing Institute of Genomics
2014-2017
University of Chinese Academy of Sciences
2012-2017
Shandong Agricultural University
2014
Abstract With the rapid development of sequencing technologies towards higher throughput and lower cost, sequence data are generated at an unprecedentedly explosive rate. To provide efficient easy-to-use platform for managing huge data, here we present Genome Sequence Archive (GSA; http://bigd.big.ac.cn/gsa or http://gsa.big.ac.cn), a repository archiving raw data. In compliance with standards structures International Nucleotide Database Collaboration (INSDC), GSA adopts four objects...
Abstract The BIG Data Center at Beijing Institute of Genomics (BIG) the Chinese Academy Sciences provides freely open access to a suite database resources in support worldwide research activities both academia and industry. With vast amounts omics data generated ever-greater scales rates, is continually expanding, updating enriching its core through big-data integration value-added curation, including BioCode (a repository archiving bioinformatics tool codes), BioProject biological project...
Meta-analysis of data from genome-wide association studies (GWAS) Alzheimer's disease (AD) has confirmed the high risk APOE and identified twenty other genes/loci with moderate effect size. However, many more remain to be discovered account for missing heritability. The contributions individual singe-nucleotide polymorphisms (SNPs) have been thoroughly examined in traditional GWAS analysis, while SNP-SNP interactions can explored by a variety alternative approaches. Here we applied...
Apple replant disease (ARD) causes the inhibition of root system development, stunts tree growth and so on. To further investigate effects ARD on apple fruits, a 25-year-old orchard was remediated to establish between November 2008 March 2009. A rotational cropping established an adjacent wheat field. The cultivar rootstock-scion combination used in newly orchards Royal Gala/M26/Malus hupehensis Rehd. Ripe fruits were collected mid-August 2011 2012, meanwhile, following indices measured:...
Peripheral blood is an attractive source for the discovery of disease biomarkers. Gene expression profiling whole or its components has been widely conducted various diseases. However, due to population heterogeneity and dynamic nature gene expression, certain biomarkers discovered from transcriptome studies could not be replicated in independent studies. In meantime, it's also important know whether a reliable biomarker shared by several diseases specific health conditions. We hypothesized...
The brain transcriptome of Alzheimer's disease (AD) reflects the prevailing mechanism at gene expression level. However, thousands genes have been reported to be dysregulated in AD brains existing studies, and consistency or dis
Glutathione-S-transferases (GSTs) are ubiquitous enzymes that play a key role in stress tolerance and cellular detoxification. The GST gene GsGST14 selected from the expression profiles of Glycine soja under alkaline was transformed into alfalfa (Medicago sativa L.). Transgenic plants showed 1.73-1.99 times higher activity than wild-type plants. grew well presence 100 mM NaHCO3, while exhibited chlorosis stunted growth, even death. There were marked changes malondialdehyde content relative...
Glutathione-S-transferases (GSTs) are ubiquitous enzymes that play a key role in stress tolerance and cellular detoxification. The GST gene GsGST14 selected from the expression profiles of Glycine soja under alkaline was transformed into alfalfa (Medicago sativa L.). Transgenic plants showed 1.73-1.99 times higher activity than wild-type plants. grew well presence 100 mM NaHCO3, while exhibited chlorosis stunted growth, even death. There were marked changes malondialdehyde content relative...