A5101902705- Ferroptosis and cancer prognosis
- Autophagy in Disease and Therapy
- Glioma Diagnosis and Treatment
- Healthcare and Venom Research
- Histone Deacetylase Inhibitors Research
- Liver Disease Diagnosis and Treatment
- Acupuncture Treatment Research Studies
- Pain Mechanisms and Treatments
- Cancer Mechanisms and Therapy
- Immune cells in cancer
- Bacterial Identification and Susceptibility Testing
- Osteoarthritis Treatment and Mechanisms
- Adipose Tissue and Metabolism
- S100 Proteins and Annexins
- Myofascial pain diagnosis and treatment
- Venomous Animal Envenomation and Studies
- interferon and immune responses
- Cystic Fibrosis Research Advances
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Radiopharmaceutical Chemistry and Applications
- Cancer-related molecular mechanisms research
- Mycobacterium research and diagnosis
- Meningioma and schwannoma management
- Cancer, Lipids, and Metabolism
Huazhong University of Science and Technology
2019-2025
Union Hospital
2019-2025
Second Affiliated Hospital of Dalian Medical University
2012-2023
The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture
2023
Dalian Medical University
2012-2023
Inner Mongolia People's Hospital
2022
Chengdu University of Traditional Chinese Medicine
2017-2021
Hubei University of Medicine
2021
Suizhou Central Hospital
2021
Wuhan No. 7 Hospital
2019
M2 tumor-associated macrophage has been found to play a supportive role in the progression of glioma. The underlying mechanism, nevertheless, largely unknown. In our study, investigate how played glioma, firstly we've analyzed clinicopathological significance existence on clinical tissues glioma using detection CD163 expression with immunohistochemistry. Then, artificially induced from human monocyte cell line THP-1, followed by co-culture lines vitro. It was that shown be markedly...
Glioblastoma (GBM) is the most lethal primary tumor of central nervous system, with its resistance to treatment posing significant challenges. This study aims develop a comprehensive prognostic model identify biomarkers associated temozolomide (TMZ) resistance. We employed multifaceted approach, combining differential expression and univariate Cox regression analyses screen for TMZ resistance-related differentially expressed genes (TMZR-RDEGs) in GBM. Using LASSO analysis, we selected 12...
To test the effects of Tanshinone IIA (Tan IIA) on cell viability, cycle, apoptosis, and autophagy human glioma U251 by regulating phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target rapamycin (mTOR) signal pathway.Tan PI3K agonist (740 Y-P) were used to treat cells U251. MTT assay was assess viability flow cytometry detect apoptosis cycle. The expressions apoptosis-related proteins (Bcl-2 Bax), autophagy-related (LC3B Beclin 1) PI3K/Akt/mTOR pathway-associated (p-PI3K, p-Akt p-mTOR)...
Chrysophanol shows promising antitumor activity, but how it may work against malignant meningioma is poorly understood. In addition, osteoglycin (OGN) help mediate the effects of chrysophanol; thus, this study investigated potential mechanism chrysophanol in cultures. Meningioma cell line HBL-52 were incubated with varying doses (0–90 μM) for different time points, and was overexpressed or inhibited some cultures to assess its roles. Cell viability quantified using CCK8 assay colony...
Aims: Gliomas are the most common malignant brain neoplasms with high recurrence and lethality rates.Recently, studies have reported that cyclin-dependent kinase 5 (CDK5) is involved in tumorigenesis.Herein, we applied bioinformatics analysis to determine clinical value of CDK5 patients glioma examined effects on glioblastoma cell proliferation, apoptosis, cycle vitro.Methods: Gene expression profiles containing data low-grade (LGG) cohorts were obtained from The Cancer Genome Atlas database...
Abstract Aims To evaluate the clinical significance of coatomer protein complex subunit beta 2 ( COPB2 ) in patients with glioma using a bioinformatics analysis. Methods Oncomine, GEO, and The Cancer Genome Atlas databases were used to examine transcript levels tissues. Gene expression profiles information from low‐grade glioblastoma (GBM) projects analyzed for associations between clinicopathologic characteristics. Kaplan‐Meier survival Cox regression analyses set enrichment analysis (GSEA)...
Brusatol (Bru), a Chinese medicine Brucea javanica extract, has variety of antitumour effects. However, its role and underlying mechanism in melanoma have not been fully elucidated. In this study, we found that brusatol inhibited cell proliferation migration promoted apoptosis vitro, addition to suppressing tumorigenesis vivo. Further studies on the revealed significantly downregulated expression stearoyl-CoA desaturase 1 (SCD1). Increased SCD1 could impair effects cells. Subsequently,...
Abstract Objective We aimed to find out the underlying mechanism of forskolin (Fsk) and 3‐isobutyl‐1‐methylxanthine (IBMX) on glioma stem cells (GSCs). Methods The expression cAMP‐related protein CREB pCREB as well apoptosis‐related proteins were detected through Western blot analysis. level proliferation growth rate human GSCs was measured thiazolyl blue tetrazolium bromide assay forming sphere assay. gene reverse transcription‐polymerase chain reaction. Results cAMP signaling pathway...
Conventional moxibustion is a representative non-drug intervention in traditional Chinese medicine, and it has been reported to produce encouraging results benefits relieving symptoms improving the quality of life for patients with knee osteoarthritis (KOA) previous clinical trials systematic reviews. Given that increasing concerns on safety generated smoke from conventional have received much attention, smoke-free regarded as potential alternative. However, whether would display similar...
Introduction Knee osteoarthritis is a common form of arthritis in elderly patients that characterised by pain and functional limitation. Moxibustion has been employed to relieve chronic as an alternative therapy for knee osteoarthritis. However, the evidence its efficacy equivocal due low methodological quality most clinical studies. Therefore, we are performing double-blinded, double-placebo, randomised controlled trial evaluate moxibustion participants with Methods analysis This...
Uncoordinated 51-like kinase 1 (ULK1) is an essential part involved in autophagy to maintain cell viability and homeostasis. Herein, the expression levels of ULK1 colon cancer (CC) were investigated, its clinicopathological features potential function analyzed. Data obtained from a public database. UCSC XENA RNAseq data uniformly processed by using Toil process. STRING was employed for identification co-expression genes development PPI networks whose interaction scores exceeded 0.4. The...
We studied the clinical implication and potential function of ATG4A in breast cancer by using publicly accessible patient data. The mRNA protein levels were up-regulated tissues compared with normal tissues. is a marker for prognosis, diagnosis therapeutic target cancer. Autophagy conservative catabolic process cell homeostasis. mechanism autophagy tumors very complicated, since it can either promote or inhibit occurrence development tumor according to different stages types. purpose this...
Gliomas are the most intrinsic type of primary intracranial tumors. The protein encoded by calponin 3 (CNN3) has been proven to be a member family. Its relationships with cervical cancer, colorectal gastric and colon cancer have emphasized several studies. Our research aims explore prognosis value immunotherapeutic targetability CNN3 in glioma patients using bioinformatics approach.CNN3 expression was analyzed based on GEO TCGA datasets. Gene profiling clinical information employed...
Previous studies have identified several ICAM3 transcript variants and mainly investigated the function of longest in various tumor progressions. However, role other remains unclear. Herein, we detected expression 1–4 DLBCL cells tissues, disclosed that 1, 3, 4 were expressed normal B cell lines 3 except SU-DHL-2 as well while variant 2 was not detected. Moreover, found ectopic enhanced proliferation by accelerating cycle SU-DHL2 vitro. In addition, overexpression showed no effects on...
Objective Leptin resistance is thought to be a main mechanism of child obesity. Suppressors-of-cytokine-signaling 3 (SOCS3) leptin inducible inhibitor signaling and potential mediator in From the aspect expression OB-Rb mRNA post-receptor signal transduction pathway, we tried probe possible pathogenesis resistance. Methods 4-week-old healthy male SD rats were fed with high-fat diet set up animal model dietary Expressions suppressors-of-cytokine-signaling mRNA, hypothalamus liver...
Objective To summarize the clinical manifestations and treatment of retinal artery occlusion cerebral infarction caused by facial injection hyaluronic acid. Methods Fifteen cases (15 eyes) with vision lose cosmetic acid visited Xi＇an No.4 Hospital from December 2010 to January 2017. The data were collected such as general medical history methods, follow-up for 1 year. Results All patients female, 22-41 years old, average age 33. All injected acid. For 8 fillers in forehead, 3...