A5028231940- Circadian rhythm and melatonin
- Genetics, Aging, and Longevity in Model Organisms
- Adipose Tissue and Metabolism
- Muscle Physiology and Disorders
- Mitochondrial Function and Pathology
- Spaceflight effects on biology
- Metabolism and Genetic Disorders
- Metabolism, Diabetes, and Cancer
- Herpesvirus Infections and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Virus-based gene therapy research
- Cancer, Hypoxia, and Metabolism
- Exercise and Physiological Responses
- Prostate Cancer Treatment and Research
- Heart Rate Variability and Autonomic Control
- Telomeres, Telomerase, and Senescence
- Nutrition and Health in Aging
- Advanced Neural Network Applications
- Plant Toxicity and Pharmacological Properties
- Microtubule and mitosis dynamics
- Fuel Cells and Related Materials
- Cancer, Lipids, and Metabolism
- Ecology and Conservation Studies
- Dietary Effects on Health
- Mass Spectrometry Techniques and Applications
Baylor College of Medicine
2020-2025
Houston Methodist
2012-2022
BioEnergetics (United States)
2018-2022
City of Hope
2018
Northeastern University
2009
Ohio University
2009
Kent State University
2009
Central Drug Research Institute
1981
Circadian clocks in adipose tissue are known to regulate adipocyte biology. Although circadian dysregulation is associated with development of obesity, the underlying mechanism has not been established. Here we report that disruption clock gene, brain and muscle Arnt-like 1 (Bmal1), mice led increased adipogenesis, hypertrophy, compared wild-type (WT) mice. This due its cell-autonomous effect, as Bmal1 deficiency embryonic fibroblasts, well stable shRNA knockdown (KD) 3T3-L1 preadipocyte...
Highlights•Biguanides activate or suppress TNBC progression in a dose-dependent manner•Biguanides regulate c-Src by the antithetical regulation of AMPK-FAO•Combination dasatinib with metformin suppresses and metastasisSummaryThe biguanide attenuates mitochondrial oxidation is proposed as an anti-cancer therapy. However, recent clinical studies suggest increased proliferation fatty acid β-oxidation (FAO) subgroup patients breast cancer (BC) after Considering that FAO can Src kinase aggressive...
The circadian clock network is an evolutionarily conserved mechanism that imparts temporal regulation to diverse biological processes. Brain and muscle Arnt-like 1 (Bmal1), essential transcriptional activator of the clock, highly expressed in skeletal muscle. However, whether this key component impacts myogenesis, a temporally regulated event requires sequential activation myogenic regulatory factors, not known. Here we report novel function Bmal1 controlling differentiation through direct...
The molecular clock is intimately linked with metabolic regulation and brown adipose tissue plays a key role in energy homeostasis. However, whether the cell-intrinsic machinery participates adipocyte development unknown. Here we show that Bmal1, essential transcription activator, inhibits adipogenesis to adversely impact fat formation thermogenic capacity. Global ablation of Bmal1 mice increases mass cold tolerance, while adipocyte-selective inactivation recapitulates these effects...
Abstract Aberrant mitochondrial energy transfer underlies prevalent chronic health conditions, including cancer, cardiovascular, and neurodegenerative diseases. Mitochondrial transplantation represents an innovative strategy aimed at restoring favorable metabolic phenotypes in cells with dysfunctional metabolism. While promising, significant barriers to vivo translation of this approach abound, limited cellular uptake recognition mitochondria as foreign. The objective is functionalize...
<ns4:p>Accumulating evidence indicates that the circadian clock, a transcriptional/translational feedback circuit generates ~24-hour oscillations in behavior and physiology, is key temporal regulatory mechanism involved many important aspects of muscle physiology. Given clock as an evolutionarily-conserved time-keeping synchronizes internal physiology to environmental cues, locomotor activities initiated by skeletal enable entrainment light-dark cycles on earth, thus ensuring organismal...
Brown adipose tissue is a major thermogenic organ that plays key role in maintenance of body temperature and whole-body energy homeostasis. Rev-erbα, ligand-dependent nuclear receptor transcription repressor the molecular clock, has been implicated regulation adipogenesis. However, whether Rev-erbα participates brown fat formation not known. Here we show regulator development by promoting Genetic ablation mice severely impairs embryonic neonatal accompanied loss identity. This defect due to...
Abstract Rev-erbα is a ligand-dependent nuclear receptor and key repressor of the molecular clock transcription network. Accumulating evidence indicate that circadian machinery governs diverse biological processes in skeletal muscle, including muscle growth, repair mass maintenance. The physiological function myogenic regulation remains largely unknown. Here we show exerts cell-autonomous inhibitory effects on proliferation differentiation precursor cells, these actions concertedly inhibit...
Circadian clock confers temporal control in metabolism, with its disruption leading to the development of insulin resistance. Metabolic substrate utilization skeletal muscle is coordinated diurnal nutrient cycles. However, whether molecular involved this coordination largely unknown. Using a myocyte-selective genetic ablation mouse model essential activator Bmal1, here we identify muscle-intrinsic as sensor feeding cues orchestrate oxidation required for global flux. Bmal1 responds robustly...
The antifertility effects of alcoholic extract Malvaviscus conzattii flowers were observed on male albino mice after oral administration 30 and 50 doses (one dose = mg/day/mouse). genital degenerative changes found to be more pronounced when the results doses. drug resulted in mass atrophy spermatogenic elements testicular stages left with only 1-2 cell layers. Epididymal epithelium was regressed lumina either devoid spermatozoa or contained its debris. flower treatment produced a...
The transformation of prostatic epithelial cells to prostate cancer (PCa) has been characterized as a transition from citrate secretion oxidation, which one would anticipate enhanced mitochondrial complex I (CI) respiratory flux. Molecular mechanisms for this are attributed declining zinc concentrations. unique metabolic properties PCa have become hot research area. Several publications provided indirect evidence based on investigations using pre-clinical models, established cell lines, and...
The adipocyte clock controls brown adipogenesis via TGF-β/BMP signaling pathway Deokhwa Nam, Bingyan Guo, Somik Chatterjee, Miao-Hsueh Chen, David Nelson, Vijay K. Yechoor, Ke Ma* Center for Diabetes Research, Department of Medicine, Methodist Hospital Research Institute, Houston, TX, 77030 Cardiovascular Second Affiliated Hospital, Hebei Medical University, Shijiazhuang, 050017, Hebei, China. Pediatrics, Children’s Nutrition Center, Molecular and Human Genetics, Endocrinology Baylor College
Isolated mitochondria are polymerically functionalized for transplantation into metabolically compromised cells. In article number 1700530, Elvin Blanco, Dale J. Hamilton, and co-workers demonstrate that coating with a dextran-triphenylphosphonium (TPP) conjugate results in longer functional survival of the organelle ex vivo, increased cellular uptake, an enhanced shift metabolic phenotype cells compared to uncoated mitochondria.
Abstract Biguanides such as metformin are one of the most widely administered anti-diabetic drugs. can suppress OXPHOS by inhibiting complex-I activity mitochondrial electron transport chain (ETC). Though recently generated lots hope in cancer therapy, several clinical trials showed only limited advantages for breast patients. Considering its long-term observed and accepted safety parameters, we investigated possible mechanisms lack vivo anticancer effect potential combination therapies....
The circadian clock exerts temporal control in metabolism and its disruption leads to the development of diabetes obesity. Tissue-intrinsic circuits are integral components global metabolic homeostasis, although how they sense nutrient signals orchestrate flux is not clear. Skeletal muscle major site for substrate oxidation, utilization glucose fatty acid depends on availability nutrients accompanying feeding-fasting transitions. Interestingly, nearly 30% rhythmic transcripts skeletal...
Circadian clock imparts temporal regulation on diverse physiological processes. We and others recently demonstrated that the circuit plays an important role in muscle growth repair for maintenance of mass, raising possibility targeting this machinery muscle‐wasting disease therapies. Currently, mechanisms underlying processes are largely unknown. Here we show antagonistic actions essential transcriptional activator, Brain Muscle Ant‐like 1 (Bmal1), repressor protein, Rev‐erbα, coordinately...
Diastolic dysfunction (DD) is prevalent in elderly post-menopausal women. In addition to impaired cardiac relaxation and output, DD associated with loss of skeletal muscle mass, strength function, exercise capacity. Understanding the mechanisms estrogen (E2)-mediated regulation structure function can have broader implications understanding progression heart disease muscle, E2 regulates autophagy mitophagy, processes that orchestrate degradation recycling damaged cellular components maintain...