A5102924746- Oral microbiology and periodontitis research
- Dental materials and restorations
- Antimicrobial Peptides and Activities
- Dental Trauma and Treatments
- Salivary Gland Disorders and Functions
- Endodontics and Root Canal Treatments
- Advanced Nanomaterials in Catalysis
- Aluminum Alloys Composites Properties
- Periodontal Regeneration and Treatments
- Protein purification and stability
- Monoclonal and Polyclonal Antibodies Research
- Advanced materials and composites
- Cell Adhesion Molecules Research
- Polymer composites and self-healing
- Antimicrobial agents and applications
- Graphene and Nanomaterials Applications
- Dental Radiography and Imaging
- Dental Erosion and Treatment
- Polymer Surface Interaction Studies
- Dental Health and Care Utilization
- thermodynamics and calorimetric analyses
- Nanoplatforms for cancer theranostics
- Advanced Drug Delivery Systems
- Bacterial biofilms and quorum sensing
- Advanced ceramic materials synthesis
Sichuan University
2001-2025
Stomatology Hospital
2025
State Key Laboratory of Oral Diseases
2013-2022
Boston University
2003-2004
To elucidate the first colonizers within in vivo dental biofilm and to establish potential population shifts that occur during early phases of formation.A 'checkerboard' DNA-DNA hybridization assay was employed identify 40 different bacterial strains. Dental samples were collected from 15 healthy subjects, 0, 2, 4 6 h after tooth cleaning composition these compared with whole saliva same individuals. The distribution distinct saliva, confirming selectivity adhesion process. In very stages,...
Dental caries is closely associated with the microbial disequilibrium between acidogenic/aciduric pathogens and alkali-generating commensal residents within dental plaque. Fluoride a widely used anticaries agent, which promotes tooth hard-tissue remineralization suppresses bacterial activities. Recent clinical trials have shown that oral hygiene products containing both fluoride arginine possess greater effect compared those alone, indicating synergy in management. Here, we hypothesize may...
Although Streptococcus sanguinis has been reported to produce H 2 O gain a competitive edge over mutans, the molecular mechanisms evolved by S. mutans counter this “peer stress” are still be identified. The current study was designed investigate ecological role of glutathione synthetase ( gshAB) in interspecies interaction between and sanguinis. A gshAB in-frame deletion strain constructed, its phenotypic traits were characterized. spatio-temporal mutant with further investigated...
Secondary caries caused by dental plaque is one of the major reasons for high failure rate resin composite restoration. Although antimicrobial agent–modified restoration systems have been researched years, few reported intelligent anticaries materials could respond to change oral environment and help keep eubiosis. Herein, we report tertiary amine (TA)–modified adhesives (TA@RAs) with pH-responsive antibacterial effect reduce occurrence secondary caries. Two kinds newly designed TA monomers...
Abstract Dynamic therapy utilizes reactive oxygen species (ROS) to antibacterial and enhance the innate immune system treat bacterial infections. If ROS levels are too low, elimination of pathogens enhancement immunity cannot be achieved. However, excess accumulation may impact intracellular glutathione (GSH) levels, hindering T cell maturation establishment memory. Herein, a multifunctional nanofiber membrane is designed, consisting polymer scaffold, MXene/CeO 2 bio‐heterojunctions (MX@Ce...
Fracture is one of the main causes for failure resin-based composite restorations. To overcome this drawback, self-healing composites have been designed by incorporation microcapsules. However, relationship between their capacity and microcapsule resin parameters still poorly understood. Therefore, objective study was to systematically investigate effect initiator concentration (in resin) size on performance commercially available flowable composites. Poly(urea-formaldehyde) (PUF)...
Human acquired enamel pellicle is composed of molecules that selectively adsorb from saliva onto tooth surfaces and provides a protective interface between the oral environment. To identify micro-amounts components present in pellicle, we immunized mice with vivo-formed human analyzed serum immune responses. Selective reactivities (OD > 1.0 above background) against albumin, amylase, carbonic anhydrase II, sIgA, IgG, IgM, lactoferrin, lysozyme, proline-rich proteins, statherin, histatin 1,...
Human acquired enamel pellicle is formed by molecules selectively adsorbed onto tooth surfaces. The present work describes the use of monoclonal antibody (mAb) technology as a novel approach to identify micro amounts components in pellicle. MAbs were obtained with reactivities against statherin, histatin, mucous glycoprotein 1(MGI), albumin, amylase and human immunoglobulins (Igs), indicating that these are components, which was further confirmed immunoblotting. No mAbs proline-rich proteins...
Fluoride agents hold promise for the repair and prevention of caries lesions, but their interaction with enamel is often hampered diminished because dynamic wet environment in oral cavity, which affects efficacy fluoride delivery limits treatment success. We herein developed a mussel-inspired adhesive system (denoted TS@NaF) fabricated by self-assembly tannic acid (TA), silk fibroin (SF), sodium (NaF). TS@NaF demonstrated remarkable biological stability biocompatibility, showed reliable...
TiB2 particulates reinforced steel matrix composites have been fabricated by a novel process with the combination of in situ and vacuum induction melting technique. With method, size ∼30 μm are homogeneously distributed matrix. The tensile test results indicate that content reinforcements has significant effect on microstructure properties composites. More more coarse particulates, higher strength smaller elongation. When reaches 13·0 vol.-%, 0·2% yield strength, ultimate elongation to...