A5101622959- Graphene and Nanomaterials Applications
- Carbon and Quantum Dots Applications
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Bone Tissue Engineering Materials
- Advanced biosensing and bioanalysis techniques
- Oral microbiology and periodontitis research
- Probiotics and Fermented Foods
- Metal-Organic Frameworks: Synthesis and Applications
- Dental materials and restorations
- Graphene research and applications
- Bacterial biofilms and quorum sensing
- Nanocluster Synthesis and Applications
- Polysaccharides and Plant Cell Walls
- Molecular Sensors and Ion Detection
- RNA Interference and Gene Delivery
- Microbial Community Ecology and Physiology
- Nanoparticles: synthesis and applications
- Infective Endocarditis Diagnosis and Management
- Seaweed-derived Bioactive Compounds
- Adsorption and biosorption for pollutant removal
- Microbial Metabolites in Food Biotechnology
- Polysaccharides Composition and Applications
- Microencapsulation and Drying Processes
- Fullerene Chemistry and Applications
State Key Laboratory of Oral Diseases
2015-2024
Sichuan University
2015-2024
Northeastern University
2023
Chengdu University
2015-2021
Stomatology Hospital
2015-2021
Carbon dots (CDs) are one of the most promising carbon-based materials in bioimaging and drug/gene delivery applications. In this study, we have attempted to study drug carrying capacity highly fluorescent CDs for doxorubicin (DOX) investigate therapeutic activity CDs-DOX system.Carbon were synthesized by means a hydrothermal approach with mixing citric acid ethylenediamine. The properties characterized respects spectral property, zeta potential, particle morphology chemical composition....
As novel applied nanomaterials, both graphene oxide (GO) and its reduced form (rGO) have attracted global attention, because of their excellent properties. However, the lack comprehensive understanding interactions with biomacromolecules highly limits biomedical applications. This work aims to initiate a systematic study on property changes GO/rGO upon interaction serum proteins how degree reduction exposure concentration affect this interaction, as well analyze possible impacts interaction....
Abstract Objectives Aptamer sgc8c is a short DNA sequence that can target protein tyrosine kinase 7 ( PTK 7), which was overexpressed on many tumour cells. This study aimed to fabricate novelty nanostructure drug delivery system 7‐positive cells— CCRF ‐ CEM (human T‐cell ALL ). Methods Aptamer‐modified tetrahedron synthesized through one‐step thermal annealing process. The sgc8c‐ TDN s (s‐ s) loading DOX complexes were applied investigate the effect 7‐negative and ‐positive Results When s‐ :...
Poor penetrability and nonselective distribution of chemotherapeutic drugs are the main obstacles for chemotherapy triple-negative breast cancer (TNBC). In our work, we developed a DNA-based drug delivery system to surmount these barriers. addition, tetrahedral framework nucleic acid (tFNA) was employed load doxorubicin (DOX) with iRGD decoration form novel nanoparticle (tFNA/DOX@iRGD). The RGD sequence CendR motif in used tumor targeting tissue penetration, respectively. Based on sustained...
Abstract Objectives Carbon dots (CDs), as a fascinating class of fluorescent carbon nanomaterials, have been proven to be powerful tools in the field bioimaging and biosensing due their small size, suitable photostability favourable biocompatibility. However, cellular uptake free CDs lacks selectivity same negative charges cell membranes may cause inefficient internalization. In this study, an efficient detecting targeting nanosystem was developed based on DNA aptamer AS1411 modified with...
Some chemotherapeutic agents, such as anthracyclines and oxaliplatin, can induce immunogenic cell death (ICD) with additional immune responses against cancer. However, ICD-based immunotherapy is limited by the nonspecific distribution of drugs various side effects. Here, an immunostimulatory self-assembled tetrahedral framework nucleic acid (tFNA) vehicle was constructed to potentiate chemo-immunotherapy, in which doxorubicin (DOX) acted a agent ICD-inducer. Meanwhile, CpG-tFNA employed...
Dentin phosphoprotein (DPP) plays an extremely important role in the biomineralization of human tooth. The repetitive nucleotide sequence aspartate-serine-serine (DSS) is fundamental unit within DPP, and peptides containing 8 repeats DSS (8DSS) have been shown to possess ability induce remineralization demineralized enamel. In this work, we coated 8DSS peptide on completely dentin evaluate effect coating remineralization. Human samples were with 37% phosphoric acid for 2 min, then (1 mg...
Abstract The present study outlines a one‐step route to the preparation and functionalization of graphene nanosheets from oxide using tea polyphenols as simultaneous reductant reagent. This method uses “green” is free additional reagents, thus it environmentally friendly, simple, low‐cost. resulting functionalized have mostly single‐layer structure, are stable, very good water dispersibility. composition, morphology material were characterized by various methods including, X‐ray diffraction...
As for cancer treatments, synergistic therapy provides outstanding strategies to facilitate multiple anticancer pathways induce improved therapeutic efficacy. Here, because of excellent physicochemical and biological properties, tea polyphenol-reduced functionalized graphene oxide (TPG) was used develop one single nanoplatform targeted photo-chemotherapy. Specifically, a multifunctional with anti-PDL1-conjugated TPG (TPDL1) as therapy, loading the drug doxorubicin hydrochloride (DOX) on...
Tetragenococcus halophilus, a halophilic lactic acid bacterium (LAB), plays an important role in the production of high-salt fermented foods. Generally, formation biofilm benefits fitness cells when faced with competitive and increasingly hostile environments. In this work, biofilm-forming capacity T. halophilus was investigated. The results showed that optimal conditions for by were at 3-9% salt content, 0-6% ethanol pH 7.0, 30°C, on surface stainless steel. Confocal laser scanning...
Abstract Straw returning has been demonstrated as a beneficial approach for the utilization of renewable biomass source, which contributes to reducing environmental pollution and strengthening sustainability agriculture. However, information on how microorganisms respond different straw return modes (SRMs) at varying nitrogen fertilizer levels (NFLs) in black soil is still limited. The community composition, network pattern, modular function bacteria fungi are investigated under three SRMs,...