A5073022207- Psoriasis: Treatment and Pathogenesis
- Axon Guidance and Neuronal Signaling
- Microtubule and mitosis dynamics
- Dermatology and Skin Diseases
- IL-33, ST2, and ILC Pathways
- Complementary and Alternative Medicine Studies
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Glioma Diagnosis and Treatment
Second Affiliated Hospital of Harbin Medical University
2018-2024
National Clinical Research Center for Digestive Diseases
2024
Harbin Medical University
2018-2024
Abstract Psoriasis is the most common skin disease in adults. Current experimental and clinical evidences suggested infiltrating immune cells could target local thus induce psoriatic phenotype. However, recent studies indicated existence of a potential feedback signaling loop from resident to cells. Here, we deconstructed full-thickness human skins both healthy donors patients with psoriasis vulgaris at single cell transcriptional level, further built neural-network classifier evaluate...
Glioblastoma multiforme (GBM) is the most malignant central nervous system tumor. Alkylating agent, temozolomide (TMZ), currently first-line chemotherapeutic agent for GBM. However, sensitivity of GBM cells to TMZ affected by many factors. And, several clinic trials, including co-administration with other drugs, have failed in successful treatment We previously reported that Netrin-4 (NTN4), a laminin-like axon guidance protein, plays protective role cell senescence upon TMZ-triggered DNA...
Psoriasis is a complex, chronic autoimmune disorder predominantly affecting the skin. Accumulating evidence underscores critical role of localized cellular inflammation in development and persistence psoriatic skin lesions, involving cell types such as keratinocytes, mesenchymal cells, Schwann cells. However, underlying mechanisms remain largely unexplored. Long non-coding RNAs (lncRNAs), known to regulate gene expression across various processes, have been particularly implicated immune...
Background While extensive research has provided a wealth of information on psoriasis in general, there remains critical gap understanding the unique characteristics special body areas, such as scalp, nails, palms, and genitals.