A5100325892- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Lung Cancer Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Ferroptosis and cancer prognosis
- Diabetes Management and Research
- Diabetes and associated disorders
- Diabetes Treatment and Management
- Cancer, Lipids, and Metabolism
- Gastric Cancer Management and Outcomes
- Neonatal Respiratory Health Research
- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Alcohol Consumption and Health Effects
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Respiratory Support and Mechanisms
- Gastrointestinal Tumor Research and Treatment
- Galectins and Cancer Biology
- Metastasis and carcinoma case studies
- Renal cell carcinoma treatment
- Cancer Treatment and Pharmacology
- Diabetes Management and Education
- Rheumatoid Arthritis Research and Therapies
- Traditional and Medicinal Uses of Annonaceae
- Alkaloids: synthesis and pharmacology
First Hospital of Jilin University
2016-2024
Jilin University
2016-2024
Jiangsu Province Hospital
2024
Nanjing Medical University
2024
Henan Provincial Chest Hospital
2023
Southern Medical University
2012-2023
Nanfang Hospital
2012-2023
Shandong First Medical University
2023
Shandong Tumor Hospital
2023
Shanghai University of Sport
2023
The heterogeneity of idiopathic pulmonary fibrosis (IPF) limits its diagnosis and treatment. association between the pathophysiological features serum protein signatures IPF currently remains unclear. present study analyzed specific proteins patterns associated with clinical parameters based on a proteomic dataset by data-independent acquisition using MS. Differentiated in sera distinguished patients into three subgroups signal pathways overall survival. Aging-associated weighted gene...
The objective of this study was to compare survival in patients with stage IIIA (N2) non-small-cell lung cancer (NSCLC) treated definitive chemoradiation (CRT) or surgery plus neoadjuvant chemotherapy (CRTS). A retrospective analysis 242 NSCLC curative intent between 1997 and 2007, identified 215 surgically resectable disease. Overall outcomes were analysed using the Kaplan–Meier plots, log-rank tests Cox proportional hazards models adjusting for age, gender, histology, smoking history...
Large amounts of time and effort are needed to implement an Internet-based glucose monitoring system (IBGMS) in the clinical setting. This study was designed using research experience that developed while implementing IBGMS Korea, platform modified evaluate efficacy controlling blood sugar Chinese population.A randomized, open-label, parallel group design used among subjects with type 2 diabetes. Over a 6-month period, 182 were evaluated (n = 92) or control 90) groups.After 3 months, group's...
Abstract Fatty acid synthase (FASN) is vital for maintaining lipid homeostasis in prostate cancer (PCa) cells, which have an increased rate of de novo fatty (FA) synthesis. Mutations the gene encoding tumor suppressor speckle‐type POZ protein (SPOP), a E3 ubiquitin ligase, are critical feature PCa. Here, we provide evidence that FASN substrate SPOP and interaction these proteins induces ubiquitination proteasome‐dependent degradation. We showed mutants commonly found PCa cannot bind to FASN....
Type 2 diabetes mellitus (T2DM) and diabetic complications threaten human health seriously. Healthy lifestyles can lower the risk of cardiovascular disease (CVD) long-term complications. However, relationship between alcohol consumption CVD mortality is still controversial, there a lack evidence from large-scale longitudinal studies in Chinese population. Based on REACTION study (Risk Evaluation Cancers Diabetic Individuals: A Longitudinal Study), this paper explores association all-cause...
We aimed to identify key genes associated with rheumatoid arthritis (RA). The microarray datasets of GSE1919, GSE12021, and GSE21959 (35 RA samples 32 normal controls) were downloaded from the Gene Expression Omnibus database. Differentially expressed (DEGs) in identified using t test limma package. Functional enrichment analysis was performed clusterProfiler A protein–protein interaction (PPI) network selected DEGs constructed based on Human Protein Reference Database. Active modules...
Aim. The relationship between alcohol consumption and glycometabolic abnormality is controversial, especially in different ethnic population. In this study, a cross-sectional survey was carried out to examine the middle-aged elderly Chinese men. Methods. Using cluster random sampling, men aged more than 40 years from Changchun, China, were given standardized questionnaires. total, 1996 individuals, for whom complete data available, recruited into study. We calculated incidence of prediabetes...
The efficiency of inhaled and systemic corticosteroids on pregnant women with chronic obstructive pulmonary disease (COPD) was investigated. study also compared the effects administration expression inflammatory mediator procalcitonin (PCT) high-sensitivity C-reactive protein (hs-CRP). A total 120 COPD patients were recruited randomly allocated into following three groups: Intravenous corticosteroid treatment group (n=42), (n=38), control (without any treatment, n=40). Patients all groups...
<title>Abstract</title> Objective To determine the efficacy and tolerability of Anlotinib plus temozolomide (TMZ) as a first-line treatment for recurrent malignant glioma (rMG). Methods A total 30 eligible patients who relapsed from standard chemoradiotherapy regimen (TMZ radiotherapy) or had macroscopic residual tumor after surgery because located in eloquent brain areas were enrolled this study between March 2018 January 2021. Patients subjected to concurrent (12mg qd, 14 days on with 7...
<sec> <title>BACKGROUND</title> Type 1 diabetes mellitus (T1DM) significantly affects patients’ quality of life and can be life-threatening, necessitating improved monitoring strategies. Telemedicine, which leverages telecommunications technologies to deliver health care services expertise, has the potential enhance T1DM management. However, its effectiveness remains fully established. </sec> <title>OBJECTIVE</title> This study aims evaluate various telemedicine-based carbohydrate-counting...
Abstract Background To promote the utilization of pulmonary function tests (PFT) through analyzing data PFT during past seven years in one large teaching hospital China.Methods Through a retrospective analysis, allocation full-time staff room, demographic characteristics patients, cost-effectiveness PFT, positive rate and failure adverse events were analyzed.Results 1) From 2012 to 2018, numbers showed trend escalation year by year. The proportion patients receiving rose from 29.0/10000...
<h3>Objective</h3> To determine the Cardiac protective effects of resveratrol in old rat with emphysema. <h3>Material and Methods</h3> Twenty-two months SD rats were divided to control (CTL) group, smoking/lipopolysaccharide (SM/LPS) group SM/LPS plus (SM/LPS-Res) group. The exposed Cigarette smoking (CS) (0.5 h/day) for eight weeks instillation LPS 200 μg/200 μl at first day 25th day. SM/LPS-Res administered (25 mg/d/kg, 1 before throughout experimental period) above-described cigarette...
<p>Pilot in vivo combination treatment studies of Kras/p53/Lkb1 lung tumors with AZD7762 and other drugs</p>
<p>In vitro treatment studies of murine Kras/p53 and Kras/p53/Lkb1 cell lines with 5FU or Pemetrexed</p>