Gastric cancer (GC) is a common malignant tumor of the digestive tract, and chemoresistance significantly impacts GC patients' prognosis. PANoptosis has been associated with oxaliplatin-induced cell death. However, direct regulatory role YBX1 in cellular through remains unclear. In this study, we investigated impact on regulating its influence resistance gastric cells to oxaliplatin. Through overexpression silencing experiments, assessed YBX1's effect proliferation regulation cells....

In this paper, we present a novel universal coupled theory for metamaterial Bound states in the continuum (BIC) or quasi-Bound (quasi-BIC) which provides ultra-high Q resonance devices. Our analytically calculates coupling of two bright modes with phase. method has much more accuracy ultra-strong comparing previous (the one mode and dark mode). Therefore, our is suitable BIC quasi-BIC can accurately predict transmission spectrum first time.

Abstract Chirality prevails in nature and is of great value for molecular biology, medicine, bioscience. Due to the enhancement chiroptical responses, chiral metasurfaces has attracted enormous attentions. In this paper, some novel polarization-sensitive transmission effects terahertz are exhibited. whose unit cell consists two basic resonators – a wire split ring resonator (SRR), we observe asymmetrical circularly polarized state from circular cross-polarization conversion spectra dichroism...

Abstract Colorectal cancer cannot be completely cured at present, and it is still an important clinical medical problem. TRAF6 highly expressed in many malignant tumors. However, the role of colorectal controversial, mainly because specific regulatory mechanism unclear, death mode cells has not been elucidated. The recent study found that inhibits necroptosis via RIPK1/RIPK3/MLKL signaling pathway. RIPK1 inhibitor Necrostain-1 cell directly interacts with through polyubiquitination...

In this paper, we present a Bound states in the continuum (BIC) metamaterial heterogeneous structures based on coupled mode theory. We find more general physical parameters to represent BIC, which are resonant frequencies and corresponding phases of structures. Therefore, BIC comes from equal value not only for homogeneous Meanwhile, if one structure's frequency phase vary by varying geometry, can obtain quasi-BIC instead broken symmetry provide with example two cut wire (CW) Split-Ring...

This paper investigates the problem of anti-jamming communication in dynamic and intelligent jamming environment. A sequential deep reinforcement learning algorithm (SDRLA) without prior information is proposed, raw spectrum used as input SDRLA. The proposed SDRLA mainly contains two parts: Firstly, sliding window principle are introduced to identify patterns; Secondly, carried out make on-line channel selection based on recognized patterns. In addition, switching cost for purpose...

This paper addresses the challenge of anti-jamming in moving reactive jamming scenarios. The jammer initiates high-power tracking upon detecting any transmission activity, and when unable to detect a signal, resorts indiscriminate jamming. presents dual imperatives: maintaining hiding avoid jammer's detection simultaneously evading Spread spectrum techniques effectively reduce transmitting power elude but fall short countering Conversely, changing communication frequencies can help evade...

Gastric cancer (GC) development trends have identified multiple processes ranging from inflammation to carcinogenesis, however, key pathogenic mechanisms remain unclear. Tissue microenvironment (TME) cells are critical for the progression of malignant tumors. Here, we generated a dynamic transcriptome map various TME during multi-disease stages using single-cell sequencing analysis. We observed set transition markers related cell carcinogenic evolution, and delineated landmark trajectories...

This letter investigates the scenario of resisting intelligent reactive jammer in mobile edge computing (MEC) networks. To solve multi-dimensional offloading allocation problem while avoiding malicious jamming attacks, a hierarchical reinforcement learning (HRL) based hybrid hidden strategy is proposed to allocate resources and reduce probability being perceived process. Specifically, HRL framework divided into two layers for asynchronous update: upper layer with discrete policy network...

We numerically demonstrate a photo-excited plasmon-induced transparency (PIT) effect in hybrid terahertz (THz) metamaterials. The proposed metamaterials are regular arrays of unit cells composed metallic cut wire and four split-ring resonators (SRRs) whose gaps filled with photosensitive semiconductor gallium arsenide (GaAs) patches. simulate the PIT controlled by external infrared light intensity to change conductivity GaAs. In absence photo excitation, GaAs is 0, thus SRR disconnected, not...

In this paper, we propose what believe to be a novel coupling mechanism for generating quasi-bound states in the continuum (quasi-BIC) symmetrical metasurface structures. We demonstrate first time theoretical predictions that supercell can induce quasi-BIC(s). utilize coupled mode theory (CMT) analyze physical generation of such structures, which result from our investigation between sub-cells are separated supercells. verify by using both full-wave simulations and experiments.

Colorectal cancer (CRC) is a formidable disease due to the intricate mechanisms that drive its proliferation and metastasis. Despite significant progress in research, integration of these influence cell behavior remains elusive. Therefore, it imperative comprehensively elucidate underlying driving CRC In this study, we reported novel role SLC26A3 suppressing progression. We found expression was downregulated CRC, which proportionally correlated with survival. Our vivo vitro experiments...

The expression of CXC motif chemokine 17 (CXCL17) and its reported membrane receptor G-protein-coupled 35 (GPR35) in different gastric pathological lesions their clinical implications are largely unknown. In this study, a total 860 sections were immune-stained with either anti-CXCL17 or anti-GPR35 antibodies. Their was scored within the area normal gland non-atrophic gastritis (NAG-NOR), intestinal metaplasia atrophic (AG-IM), IM adjacent to GC (GC-IM), tissue. significance potential...

In this study, we use a phase-changing material vanadium dioxide (VO2) to design multilayer metasurface structure achieve the transition from an electromagnetically induced transparency(EIT) device absorber. The consists of gold layer, polyimide spacer VO2 and sapphire substrate. top layer one cut wire two split-ring resonators with same parameters. When is in its insulating phase at room temperature, peak EIT will appear near 1.138 THz. metallic state, absorption peaks above 99.5%...

In this paper, we present a full quantum description for coupling mechanism of the metamaterial. We start derivation from master equation to fit spectrum THz Therefore can employ describe metamaterial, such as electromagnetically induced transparency (EIT) and bound state in continuum (BIC). build up bridge between so-called quantum–classical analogies. Based on our theory, find more phenomenon with corresponding

This paper investigates the problem of multidimensional resource management in multi-access mobile edge computing (MEC) networks against external dynamic jamming. The objective is to minimize long-term computational cost MEC network while satisfying task computation delay requirements user equipment (UE) by jointly optimizing and communication allocation. To overcome challenges such as frequency conflict jamming attacks, a distributed multi-agent hierarchical deep reinforcement learning...

In this paper, we focus on detecting the MAC spoofing attack in physical-layer (PHY-layer) by using a centralized cooperative detection algorithm multi-user networks. Specifically, propose an approach that exploits channel fingerprints power (CFPP) slow time-varying fading and derive CFPP estimation with consideration of error. As it is challenging for suspect factor function design, design discuss its properties. Then, proposed. Simulations validate proposed can achieve better performance.

Background Interleukin 20 receptor A (IL20RA) has been shown to play a role in the establishment and progression of multiple tumors. However, expression this protein colorectal cancer (CRC) its correlation with clinicopathological parameters CRC have remained unclear. Methods total 323 paraffin sections including tissues adjacent normal after surgery were collected. IL20RA was detected by immunohistochemical staining. The difference mRNA between also explored Oncomine GEO databases. In...

This paper investigates multi-domain anti-jamming communication in a malicious jamming and channel fading environment using deep reinforcement learning (DRL). Unlike existing research, which mainly focuses on single-domain methods such as frequency selection power control, is considered to cope with dynamic the cognitive radio scene. We consider whether transmit at current time slot domain joint channel-bandwidth domain. To represent state, A two-dimensional time-frequency spatial-spectral...

Background The gut microbiota is very important for maintaining the homeostasis and health of crustaceans. Many factors affect crustaceans, one which temperature. However, it currently unclear how temperature affects metabolites Procambarus clarkii . Methods Using metagenomic sequencing gas chromatography–mass spectrometry (GC–MS) techniques, P. from Hubei (HB), Jiangsu (JS), Shandong (SD), Zhejiang (ZJ) in China were investigated. Results Under impact temperature, exhibit a specific trend...

To explore immune-related molecules that affect the prognosis of endometrial carcinoma (EC) using bioinformatic data mining. The expression related to EC were downloaded from Cancer Genome Atlas (TCGA) and Gene Expression Omnibus databases. After differential analysis, intersection with immune genes in ImmPort database was used obtain differentially expressed (IRDEGs). correlation between clinicopathological information IRDEGs further analyzed (PRDEIG). analysis Set Enrichment Analysis...

Inflammatory bowel disease (IBD), including Crohn's (CD) and ulcerative colitis (UC), is a chronic, inflammatory, autoimmune disease, but its specific etiology pathogenesis are still unclear. This study aimed to better discover the causative basement membrane (BM) genes of their subtypes associations. The differential expression BM between CD UC was analyzed validated by downloading relevant datasets from GEO database. We divided samples into 3 groups for comparative analysis. Construction...