A5078397753- RNA modifications and cancer
- RNA Research and Splicing
- NF-κB Signaling Pathways
- Cancer-related molecular mechanisms research
- RNA and protein synthesis mechanisms
- Genetic Syndromes and Imprinting
- Epigenetics and DNA Methylation
- interferon and immune responses
- MicroRNA in disease regulation
- Endometrial and Cervical Cancer Treatments
- Circular RNAs in diseases
- Immune cells in cancer
- Immune Response and Inflammation
- Silk-based biomaterials and applications
- Galectins and Cancer Biology
- Inflammatory Bowel Disease
- Skin and Cellular Biology Research
- Cancer Mechanisms and Therapy
- Cytokine Signaling Pathways and Interactions
- Invertebrate Immune Response Mechanisms
- Nanoplatforms for cancer theranostics
- Cancer, Lipids, and Metabolism
- Cell Adhesion Molecules Research
- Wnt/β-catenin signaling in development and cancer
- Cancer-related gene regulation
Fujian Medical University
2019-2025
First Affiliated Hospital of Fujian Medical University
2019-2025
The University of Texas Health Science Center at San Antonio
2020
Gastric cancer (GC) is a common malignant tumor of the digestive tract, and chemoresistance significantly impacts GC patients' prognosis. PANoptosis has been associated with oxaliplatin-induced cell death. However, direct regulatory role YBX1 in cellular through remains unclear. In this study, we investigated impact on regulating its influence resistance gastric cells to oxaliplatin. Through overexpression silencing experiments, assessed YBX1's effect proliferation regulation cells....
The role of myeloid differentiation factor 88 (MyD88) in malignant tumors is largely unknown. Therefore, this study, we aimed to examine the function and underlying mechanism MyD88 colorectal carcinoma vitro using SW480 HCT116 cell lines vivo a nude mouse model. cells were infected with lentiviral‑based effective siRNA virus. CCK‑8 colony formation assay used assess proliferation. Transwell scratch assays test migration cancer cells, was further analyze invasiveness cells. Western blotting...
Abstract Colorectal cancer cannot be completely cured at present, and it is still an important clinical medical problem. TRAF6 highly expressed in many malignant tumors. However, the role of colorectal controversial, mainly because specific regulatory mechanism unclear, death mode cells has not been elucidated. The recent study found that inhibits necroptosis via RIPK1/RIPK3/MLKL signaling pathway. RIPK1 inhibitor Necrostain-1 cell directly interacts with through polyubiquitination...
Abstract Gastric cancer is an aggressive malignancy with poor patient outcomes. N-Acetyltransferase 10 (NAT10) acetyltransferase that has been reported to contribute gastric progression. In-depth investigation into the underlying molecular mechanisms driven by NAT10 could help identify therapeutic targets improve treatment. In this study, we found forms condensates regulate RNA dynamics and promote samples of patients cancer, elevated expression correlated unfavorable prognosis, advanced...
Abstract Uncontrolled recurrence and metastasis are important reasons for the high mortality rate of malignant tumors. Vimentin is positively correlated with degree malignancy cancer cells. also highly expressed in colorectal (CRC) cells plays a critical role prognosis CRC. However, molecular mechanism vimentin progression CRC incompletely understood. Therefore, most active regions (nucleotides: 785–1085 nt) promoter were identified using luciferase experiments. By transcription factor...
Abstract The cGAS‐STING signaling pathway is a pivotal immune response mechanism that bridges tumor and cell interactions. This study describes multifunctional LPDAM nanoplatform integrating Lapachone, polydopamine (PDA), Mn 2+ , which synergistically kills cells activates the pathway, thereby inducing DC maturation T activation to achieve potent antitumor immunity. In microenvironment, Lapachone generates H 2 O via NAD(P)H:quinone oxidoreductase 1 (NQO1 enzyme), while catalyze conversion...
Inflammation may play a role in cancer initiation and progression. The molecular mechanisms by which inflammation causes colorectal cancer, remains unclear. present study investigated signaling pathway that affects cancer.SW480 cells, HCT116 cells with knockdown of myeloid differentiation 88 (MyD88), forced expression MyD88 were treated lipopolysaccharide (LPS; 1 μg/ml). Inflammation-related mRNA was analyzed the quantitative reverse transcription polymerase chain reaction inflammatory...
Abstract N6,2′‐ O ‐dimethyladenosine (m 6 A) RNA methylation, which is correlated with cancer initiation and progression, dynamically regulated by m A methylation regulators, including writers, erasers, readers. Two subgroups of rectal cancer, cluster1 cluster2, were identified based on consensus clustering to regulators. protein–protein interaction network was constructed hub genes identified. The results demonstrated that the expression WTAP significantly associated YTHDC1 YTHDF2 ....
Abstract Background Epigenetic alterations are involved in most cancers, but its application cancer diagnosis is still limited. More practical and intuitive methods to detect the aberrant expressions from clinical samples using highly sensitive biomarkers needed. In this study, we developed a novel approach identifying, visualizing, quantifying biallelic multiallelic of an imprinted gene panel associated with status. We evaluated normal measured formulate diagnostic models which could...
Colorectal cancer (CRC) is a formidable disease due to the intricate mechanisms that drive its proliferation and metastasis. Despite significant progress in research, integration of these influence cell behavior remains elusive. Therefore, it imperative comprehensively elucidate underlying driving CRC In this study, we reported novel role SLC26A3 suppressing progression. We found expression was downregulated CRC, which proportionally correlated with survival. Our vivo vitro experiments...
Background/Aim: Colorectal cancer (CRC) cells secrete inflammatory cytokines that affect CRC progression. The aim of the present study was to determine if micro-RNA-140(miR-140) regulates cytokine secretion induced by lipopolysaccharide (LPS) in colorectal targeting tumor necrosis factor receptor (TNFR)-associated 6 (TRAF6). Materials and Methods: Fifty fresh colon-cancer specimens normal tissues were collected from patients with tested for expression miR-140. Human cell lines SW480 HCT116...
Background and Aim: Some studies have confirmed that miRNA-140 exhibits a suppressive role in gastric cancer, Wilms’ tumor. However, the function of colorectal cancer has not been completely elucidated. The present study aims to verify TRAF6 as targeted gene by which was investigated tissues cells, its effects on biological characteristics cells were determined, order provide an experimental theoretical basis for application treatment cancer. Methods: qPCR analyzed expression levels tissues,...
To explore immune-related molecules that affect the prognosis of endometrial carcinoma (EC) using bioinformatic data mining. The expression related to EC were downloaded from Cancer Genome Atlas (TCGA) and Gene Expression Omnibus databases. After differential analysis, intersection with immune genes in ImmPort database was used obtain differentially expressed (IRDEGs). correlation between clinicopathological information IRDEGs further analyzed (PRDEIG). analysis Set Enrichment Analysis...
Inflammatory bowel disease (IBD), including Crohn's (CD) and ulcerative colitis (UC), is a chronic, inflammatory, autoimmune disease, but its specific etiology pathogenesis are still unclear. This study aimed to better discover the causative basement membrane (BM) genes of their subtypes associations. The differential expression BM between CD UC was analyzed validated by downloading relevant datasets from GEO database. We divided samples into 3 groups for comparative analysis. Construction...
<p>Raw data</p>
<div>Abstract<p>Gastric cancer is an aggressive malignancy with poor patient outcomes. N-Acetyltransferase 10 (NAT10) acetyltransferase that has been reported to contribute gastric progression. In-depth investigation into the underlying molecular mechanisms driven by NAT10 could help identify therapeutic targets improve treatment. In this study, we found forms condensates regulate RNA dynamics and promote samples of patients cancer, elevated expression correlated unfavorable...
<p>Raw data</p>
<p>Supplementary Tables</p>
<p>Supplementary Figures</p>
<p>Supplementary Materials and Methods</p>
Background/Aim: Endometrial carcinoma (EC) is the most common gynecological cancer, but lacks specific targetable markers. In order to explore immune-related molecules that affect progression and prognosis of EC, we analyzed differential expression genes in different histological grades disease. Materials Methods: EC-related gene-expression data were downloaded from TCGA GEO databases. The list was obtained ImmPort database. identity differentially-expressed (DEGs), differential-expression...