Conventional measurements are not always helpful in the diagnosis of malignant mesothelioma (MM). Increasing studies indicate that loss BRCA1-associated protein 1 (BAP1) detected by immunohistochemistry (IHC) is a useful diagnostic marker for MM. In this meta-analysis, we investigated accuracy BAP1 MM.In total, 12 eligible with total 1824 patients were selected. Results indicated sustained pooled sensitivity 0.56 (95% CI, 0.50-0.62), specificity 1.00 0.95-1.00), PLR 548.82 11.31-2.7 × 104),...

To evaluate the association of 12 tag single nucleotide polymorphisms (tagSNPs) in three onco-long non-coding RNA (lncRNA) genes (HOTTIP, CCAT2, MALAT1) with risk and prognosis hepatocellular cancer (HCC).Twelve tagSNPs covering onco-lncRNAs were genotyped by KASP method a total 1338 samples, including 521 HCC patients frequency-matched 817 controls. The samples obtained from an unrelated Chinese population at First Hospital China Medical University 2012-2015. expression quantitative trait...

Background This study aimed to analysis the relationship between sodium intake and risk of heart failure hypertension through epidemiological studies Mendelian randomization analysis. Methods result We initially conducted an using data from National Health Nutrition Examination Survey (NHANES) database examine failure, hypertension, systolic blood pressure, diastolic pressure. After adjusting for confounding factors, we found a non-linear association (p nonlinear = 0.0448). Subsequently,...

Gastric mucosal immune microenvironment plays an important role in the occurrence and development of diseases such as inflammation cancer. In present study, single-sample gene set enrichment analysis (ssGSEA) was used to evaluate expression cytokines degree cell infiltration four different gastric mucosa tissues from normal mucosa, simple gastritis, atrophic gastritis Here, we show microenvironments these mucosae were significantly different. From cancer, most immunoinflammatory cells showed...

N6-methyladenosine (m6A) modification might be closely associated with the genesis and development of gastric cancer (GC). Currently, evidence established by high-throughput assay for GC-related m6A patterns based on long non-coding RNAs (lncRNAs) remains limited. Here, a joint analysis lncRNA methylome lncRNA/mRNA expression profiles in GC was performed to explore regulatory roles lncRNAs. Three subjects primary were enrolled our study paired sample randomly selected from tissue adjacent...

Objective:The microsatellite status and tumor immune microenvironment have a remarkable influence on immunotherapy.This study was performed to investigate programmed cell death protein 1/programmed ligand 1 (PD1/PDL1) expression their correlations with CD8+ T cell/CD68+ macrophage (CD68+ M) densities in gastric cancer (GC) at different statuses.Methods: The of MLH1, PMS2, MSH2, MSH6 detected via immunohistochemistry (IHC) determine the 215 GC samples obtained from surgical...

Abstract To explore the mutation characteristics of H. pylori resistance‐related genes to antibiotics clarithromycin (CAM), levofloxacin (LVX) and metronidazole, 23SrRNA, gyrA , gyrB rdxA, frxA were amplified sequenced, respectively. Molecular docking study was performed molecular interactions between chemotherapeutic agents target proteins. In CAM‐resistant strains, rate in site A2143G 74.2% (n = 23). The sites G1949A, C1953T, G2211T with CAM weaker after mutation. LVX‐resistant rates 87 (N...

As the largest gene family functioning in protein transport among human solute carriers, SLC25 (mitochondrial carrier family) can participate development of cancer. However, a comprehensive exploration for exactly roles SLC remains lacking. In present study, total 15 functional genes were retrieved from all current publications. And multidimensional analyses systematically performed based on transcriptome and genome data variety online databases their expression, immune cell infiltration,...

The role of long non-coding RNA (lncRNA) HOXA transcript at the distal tip (HOTTIP) as an oncogene in varieties human cancer including colorectal (CRC) has been extensively researched. expression and function lncRNAs could be affected by single nucleotide polymorphisms (SNPs), which are associated with susceptibility prognosis. However, no investigation focused on association between HOTTIP SNPs CRC. aim present study was to explore lncRNA gene CRC risk prognosis.A total 1848 subjects were...

Low rectal cancer is a subtype of colorectal at special anatomic site with distinct biological behavior. TP53 one the most important suppressor genes, and its structural variation abnormal expression has been revealed to be associated multiple types. However, best our knowledge, association p53 protein gene polymorphism, behavior prognosis in low not clarified. Therefore, current study aimed explore these associations. In present study, 347 patients 353 controls were enrolled. Kompetitive...

// Zhi Lv 1, * , Liping Sun Qian Xu 1 Yuehua Gong Jingjing Jing Chengzhong Xing and Yuan Tumor Etiology Screening Department of Cancer Institute General Surgery, The First Affiliated Hospital China Medical University, Key Laboratory Prevention Liaoning Provincial Education Department, Shenyang 110001, These authors contributed equally to this work Correspondence to: Yuan, email: yuanyuan@cmu.edu.cn Keywords: LncRNA, polymorphism, gastric cancer, susceptibility, prognosis Received: May 24,...

Objective: TNFAIP2 is a novel gene induced by TNF-α and participates in inflammatory reaction tumor angiogenesis. This study aims to understand the correlation between polymorphism prediction as well prognosis of gastric cancer (GC) Chinese population. Methods: One thousand two hundred seventy-nine cases were enrolled, including 640 GC 639 non-cancer cases. The functional tagSNPs screened Haploview software NIH Snpinfo website. Human whole-blood genomic DNA was extracted phenol chloroform...

Multidimensional interactions of multiple factors are more important in promoting cancer initiation. Gene-gene between protein-coding genes have been paid great attention, while rare studies refer to the encoding and noncoding genes. Our research group previously found gene PGC polymorphisms could affect susceptibility atrophic gastritis (AG) gastric (GC). Interestingly, several SNPs long RNA (lncRNA) genes, just adjacent PGC, were be associated with AG risk GC prognosis afterward. This...

Purpose: The study was conducted to investigate the relationship of serum pepsinogens PGI, PGII, gastrin-17, and Hp-IgG with colorectal cancer (CRC), aiming explore clinical significance markers reflecting gastric function H. pylori infection in CRC. Methods: A total 569 CRC cases age sex-matched controls were enrolled this between June 2012 April 2016 from First Hospital China Medical University. detected using ELISA, including PGI/II ratio, G-17 Hp-IgG. Information clinicopathological...