A5022836896- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Treatment and Research
- Peptidase Inhibition and Analysis
- Urinary and Genital Oncology Studies
- Cancer Immunotherapy and Biomarkers
- Protease and Inhibitor Mechanisms
- Renal cell carcinoma treatment
- Radiopharmaceutical Chemistry and Applications
- Urological Disorders and Treatments
- Virus-based gene therapy research
- CAR-T cell therapy research
- Hormonal and reproductive studies
- Adenosine and Purinergic Signaling
- COVID-19 Clinical Research Studies
- Urinary Bladder and Prostate Research
- Chemokine receptors and signaling
- Intensive Care Unit Cognitive Disorders
- Sarcoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Xenotransplantation and immune response
- Histone Deacetylase Inhibitors Research
- Inflammasome and immune disorders
- Prostate Cancer Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Transplantation: Methods and Outcomes
Ludwig-Maximilians-Universität München
2019-2025
LMU Klinikum
2019-2025
Beth Israel Deaconess Medical Center
2015-2016
Harvard University
2015-2016
Severe acute respiratory syndrome corona virus 2 infection causes severe pneumonia (coronavirus disease 2019 [COVID-19]), but the mechanisms of subsequent failure and complicating renal myocardial involvement are poorly understood. In addition, a systemic prothrombotic phenotype has been reported in patients with COVID-19.A total 62 subjects were included our study (n=38 reverse transcriptase polymerase chain reaction-confirmed COVID-19 n=24 non-COVID-19 controls). We performed...
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can lead to pneumonia, but also thrombotic complications and non-pulmonary organ failure. Recent studies suggest intravascular neutrophil activation subsequent immune cell-triggered immunothrombosis as a central pathomechanism linking the heterogenous clinical picture of disease 2019 (COVID-19). We sought study whether is pathognomonic factor in COVID-19 or general feature (viral) well better understand its upstream...
Abstract Progressive respiratory failure and hyperinflammatory response is the primary cause of death in coronavirus disease 2019 (COVID-19) pandemic. Despite mounting evidence disruption hypothalamus-pituitary-adrenal axis COVID-19, relatively little known about tropism severe acute syndrome 2 (SARS-CoV-2) to adrenal glands associated changes. Here we demonstrate viral replication COVID-19 patients. Adrenal showed inflammation accompanied by inflammatory cell death. Histopathologic analysis...
Variant histologies of bladder cancer (BC) often present with advanced tumor stage and the status perioperative therapy is unclear. Thereby, squamous cell carcinoma (SCC), adenocarcinoma (ADENO), sarcomatoid urothelial (SARCO) are most frequent variants. Nectin-4 has emerged as a highly interesting target in BC might guide therapeutic application antibody−drug conjugates (ADC). We therefore aimed to investigate expression patterns prognostic value variant BC. A single-center retrospective...
T cell suppression in sepsis is a well-known phenomenon; however, the underlying mechanisms are not fully understood. Previous studies have shown that stimulation up-regulates mitochondrial adenosine triphosphate (ATP) production to fuel purinergic signaling necessary for adequate responses. Here we show basal ATP production, release, and of P2X1 receptors represent standby mechanism antigen recognition. Inhibition this process impairs vigilance ability cells trigger activation, up-regulate...
[68Ga]Ga-FAPI-46 is a novel positron emission tomography (PET) ligand that targets fibroblast activation protein (FAP) expression as FAP inhibitor (FAPI) and could already show promising results in several tumor entities. It be demonstrated an increased correlates with aggressivity urothelial carcinoma (UC). Given the limited value of [18F]FDG UC, add diagnostic information staging response assessment UC. We present first data PET imaging pilot cohort UC patients evaluating uptake...
Orthotopic cardiac xenotransplantation has seen substantial advancement in the last years and initiation of a clinical pilot study is close. However, donor organ overgrowth been major hurdle for preclinical experiments, resulting loss function decease recipient. A better understanding pathogenesis after necessary before application.Hearts from genetically modified ( GGTA1-KO , hCD46/hTBM transgenic) juvenile pigs were orthotopically transplanted into male baboons. Group I (control, n = 3)...
Abstract Although initially assumed to be similar, immune checkpoint inhibitor (ICI)-induced autoimmunity can differ from spontaneous autoimmune disease regarding clinical presentation, pathogenesis and therapy. Despite limited pathogenetic understanding, ICI-induced colitis (irColitis), a common adverse event during ICI therapy, is treated analogously its counterpart, ulcerative (UC). Thus, there tremendous need characterize immunophenotypes in both forms of colonic inflammation ultimately...
Bladder cancer is amongst the most common causes of death worldwide. Muscle-invasive bladder (MIBC) bears a particularly poor prognosis. Overexpression purinergic P2X receptors (P2XRs) has been associated with worse outcome in several malignant tumors. Here, we investigated role P2XRs cell proliferation vitro and prognostic value P2XR expression MIBC patients. Cell culture experiments T24, RT4, non-transformed TRT-HU-1 cells revealed link between high ATP concentrations supernatants lines...
The blockade of the CD40/CD40L immune checkpoint is considered essential for cardiac xenotransplantation. However, it still unclear which single antibody directed against CD40 or CD40L (CD154), combination antibodies, better at preventing organ rejection. For example, high doses administered in previous experiments might not be feasible treatment humans, while thrombotic side effects were described first-generation anti-CD40L antibodies. To address these issues, we conducted six orthotopic...
Delineation of PSMA-positive tumor volume on PET using PSMA-ligands is highest clinical interest as changes PSMA-PET/CT-derived whole (WTV) have shown to correlate with treatment response in metastatic prostate cancer patients. So far, WTV estimation was performed 68Ga-labeled ligands; nonetheless, 18F-labeled ligands are gaining increasing importance due advantages over compounds. However, standardized delineation methods for not been established so far. As correlation PET-based information...
Abstract Introduction [ 68 Ga]Ga-FAPI-46 PET/CT is a novel hybrid imaging method that previously showed additional diagnostic value in the assessment of distant urothelial carcinoma lesions. We hypothesized patients with bladder cancer benefit from prior to radical cystectomy for locoregional lymph node staging. Materials and methods Eighteen underwent evaluation (LN) status predefined LN regions. Two hundred twenty-nine intraoperatively removed served as histopathological reference...
Sinonasal mucosal melanoma (SNMM) is a rare but aggressive tumor with poor prognosis. The co-inhibitory receptors T cell immunoglobulin and mucinodomain containing-3 (TIM-3), lymphocyte activation gene-3 (LAG-3) immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) are promising new targets in anti-cancer immunotherapy. expression profiles of these immune checkpoint molecules (ICMs) potential prognostic implications have not been characterized SNMM yet. Immunohistochemical staining...
Hypertonic saline (HS) resuscitation has been studied as a possible strategy to reduce polymorphonuclear neutrophil (PMN) activation and tissue damage in trauma patients. blocks PMNs by adenosine triphosphate (ATP) release stimulation of A2a receptors. Here, we the underlying mechanisms search reasons for inconsistent results recent clinical trials with HS resuscitation. Purified human or whole blood were treated simulate hypertonicity levels found after (40 mmol/L beyond isotonic levels)....
Tumor-infiltrating lymphocytes (TILs) predict better outcome in several types of cancers. However, the prognostic value TILs sinonasal mucosal melanoma (SNMM) is uncertain. Here, we investigated whether can be used as a indicator for survival SNMM.Retrospective cohort study.Patient history and histologic specimens from 27 patients with primary SNMM were retrospectively analyzed. TIL grade was determined associations between AJCC tumor stage, overall survival, recurrence-free...
68Ga-EMP-100 is a novel positron emission tomography (PET) ligand that directly targets tumoral c-MET expression. Upregulation of the receptor tyrosin kinase in renal cell carcinoma (RCC) correlated with overall survival metastatic disease (mRCC). Clinicopathological staging expression could improve patient management prior to systemic therapy for instance inhibitors targeting such as cabozantinib. We present first in-human data mRCC patients evaluating uptake characteristics metastases and...
Abstract Purpose To detect SARS-CoV-2 RNA in post-mortem human eyes. Ocular symptoms are common patients with COVID-19. In some cases, they can occur before the onset of respiratory and other symptoms. Accordingly, has been detected conjunctival samples tear film suffering from However, detection clinical relevance intravitreal still remain unclear due to so far contradictory reports literature. Methods our study 20 confirmed diagnosis COVID-19 were evaluated assess intraocular presence...
Recently, the European Association of Urology recommended hexane-extracted fruit Serenoa repens (HESr) in their guidelines on management non-neurogenic male lower urinary tracts symptoms (LUTS). Despite previously lacking recommendations, Permixon® is most investigated HESr clinical trials, where it proved effective for LUTS. In contrast, underlying mechanisms were rarely addressed and are only marginally understood. We therefore effects human prostate detrusor smooth muscle contraction...
In renal cell carcinoma (RCC), accurate imaging methods are required for treatment planning and response assessment to therapy. addition, there is an urgent need new therapeutic options, especially in metastatic RCC. One way combine diagnostics therapy a so-called theranostic approach the use of radioligands directed against surface antigens. For instance, prostate-specific membrane antigen (PSMA) have already been successfully used diagnosis radionuclide prostate cancer. Recent studies...
Background: Our study endeavors to elucidate the clinical implications of PD-L1 positivity in individuals afflicted with advanced urothelial carcinoma bladder (UCB). Methods: Patients UCB were prospectively enrolled following a radical cystectomy (RC) performed within January 2017 December 2022 at our tertiary referral center. The outcome, defined as progression-free survival (PFS) and overall (OS) on systemic treatment, was analyzed using an χ2-test, Mann–Whitney U-test, Kaplan–Meier...