A5054308015- Cancer, Lipids, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Cancer-related molecular mechanisms research
- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Cancer Immunotherapy and Biomarkers
- Acute Myeloid Leukemia Research
- Lipid metabolism and disorders
- Ferroptosis and cancer prognosis
- Lung Cancer Treatments and Mutations
- Angiogenesis and VEGF in Cancer
- Head and Neck Cancer Studies
- Gastric Cancer Management and Outcomes
- Endometrial and Cervical Cancer Treatments
- Protease and Inhibitor Mechanisms
- Polyomavirus and related diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer Research and Treatments
- Immune cells in cancer
- Venous Thromboembolism Diagnosis and Management
- Cancer, Hypoxia, and Metabolism
- Bone and Dental Protein Studies
- Respiratory viral infections research
- Immune Cell Function and Interaction
- Liver Disease Diagnosis and Treatment
Sun Yat-sen University
2014-2023
Sun Yat-sen University Cancer Center
2014-2023
State Key Laboratory of Oncology in South China
2014-2022
University of Colorado Denver
2022
University of Colorado Cancer Center
2022
Although the alterations of lipid profile in lung cancer have been documented, prognostic value serum HDL-C level and its correlation with inflammation NSCLC remain unknown.Levels preoperative concentrations (including HDL-C, LDL-C, TC, TG) inflammatory biomarker C-reactive protein (CRP) were retrospectively analyzed 228 patients 300 healthy controls. The levels these two populations compared. Univariate multivariate cox hazards analyses performed to investigate NSCLC. between CRP also...
Multiple studies have reported the prognostic association of certain inflammatory factors with various types cancer. The present study assessed value C-reactive protein (CRP)/albumin (Alb) ratio and neutrophil/lymphocyte (NLR), separately in combination, gastric cancer (GC). A total 337 cases pathologically diagnosed adenocarcinoma were retrospectively evaluated. clinicopathological relevance CRP/Alb NLR their combination analyzed. optimal cut-off values 0.38 3.14, respectively. High (≥0.38)...
To evaluate whether serum Cathepsin S (Cat S) could serve as a biomarker for the diagnosis and prognosis of gastric cancer (GC), Enzyme-linked immuno sorbent assay (ELISA) was used to detect Cat in 496 participants including healthy controls patients with benign diseases, cancer, esophageal liver colorectal nasopharyngeal lung cancer. The levels were significantly increased patients, especially GC patients. qRT-PCR, Western blotting, immunohistochemical staining revealed overexpression cell...
Aims: The levels of coagulation system tests have been studied in various cancers. In this study, our aim is to evaluate the prognostic value pretreatment plasma hepatocellular carcinoma (HCC) patients. Patient and methods: A retrospective study was performed 539 patients with HCC, follow-up period at least 60 months until recurrence or death. significance (prothrombin time, activated partial thromboplastin thrombin fibrinogen) were determined by univariate multivariate Cox hazard models....
The aim of this study was to propose a prognostic scoring system based on preoperative serum apolipoprotein A-1 and C-reactive protein (ApoA-1 CRP, AC score) levels evaluate the value these markers in patients with hepatocellular carcinoma (HCC). In all, 539 consecutive cases diagnosed HCC from 2009 2012 at Sun Yat-sen University Cancer Center were analysed. characteristics pretreatment lipids (ApoA-1, B (Apo-B), high-density lipoprotein cholesterol (HDL-C), low-density (LDL-C), total (TC),...
This study was designed to establish an ELISA method, as well the cut-off value, for IgA against Epstein-Barr virus (EBV) viral capsid antigen (VCA), a screening assay nasopharyngeal carcinoma (NPC) in southern China. In addition, correlation between relative optical density (rOD) values from and titers immunoenzymatic (IEA) also evaluated.Two hundred fifty-eight NPC cases, 33 non-NPC head neck cancer patients, 1156 healthy controls were recruited this study. VCA-IgA early (EA)-IgA measured...
Activation of coagulation and fibrinolysis has been observed in many tumors. Our study aimed to investigate the clinical prognostic significance various plasma tests patients with cervical cancer. A total 296 cancer were included analysis. Patients followed up for at least 60 months until death. Pretreatment parameters including activated partial thromboplastin time, D-dimer, fibrinogen, prothrombin thrombin lactate dehydrogenase, squamous cell carcinoma antigen evaluated. Prothrombin time...
Background: Gastric cancer (GC) is the fifth most common worldwide, approximately 950,000 individuals are diagnosed with gastric causing 800,000 mortalities every year. Our study aimed to establish an effective nomogram predict prognosis of GC patients, which based on inflammation biomarkers. Methods: We retrospectively analysed patients from Sun Yat-sen University Cancer Center between 2009 and 2017. The was developed a primary cohort (n=1067), 537 included in validation cohort. Univariate...
Summary Interactions between acute myeloid leukaemia (AML) cells and immune are postulated to corelate with outcomes of AML patients. However, data on T‐cell function‐related signature not included in current survival prognosis models. We examined RNA matrices from 1611 persons extracted public databases arrayed a training three validation cohorts. developed an eight‐gene using the random forest variable hunting algorithm. Accuracy gene identification was tested real‐world cohort by...
Background: Gastric cancer (GC) is the fifth most common worldwide. Our study aimed to establish an effective nomogram integrated with inflammation-based factors predict prognosis of GC patients.Methods: We retrospectively analysed patients from Sun Yat-sen University Cancer Center between 2009 and 2017. The was established a primary cohort (n=1067), validation included 537 patients. Univariate multivariate Cox survival analyses were used identify prognostic factors. tested accuracy by...
Abstract Background Accurate assessment of the nature enlarged retropharyngeal lymph nodes (RLN) nasopharyngeal carcinoma (NPC) patients after radiotherapy is essential for planning treatment. This study aimed to develop a non-invasive and effective model predicting recurrence RLN (RRLN) in NPC. Methods The data post-radiotherapy NPC (N = 76) with abnormal enlargement who underwent endonasopharyngeal ultrasound-guided fine-needle aspirations (EPUS-FNA) were examined. They randomly divided...