A5104287422- Genetic Syndromes and Imprinting
- Genetics and Neurodevelopmental Disorders
- Cellular Mechanics and Interactions
- Cancer-related molecular mechanisms research
- Genomic variations and chromosomal abnormalities
- Protein Kinase Regulation and GTPase Signaling
- Cell Adhesion Molecules Research
- Congenital heart defects research
- Cancer, Hypoxia, and Metabolism
- Autism Spectrum Disorder Research
- Prenatal Substance Exposure Effects
- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Lipids, and Metabolism
- Mesenchymal stem cell research
- RNA Research and Splicing
- Aldose Reductase and Taurine
- Advanced Neuroimaging Techniques and Applications
- Mechanisms of cancer metastasis
- Pancreatic function and diabetes
- Adenosine and Purinergic Signaling
- Sleep and Wakefulness Research
- Ubiquitin and proteasome pathways
- 3D Printing in Biomedical Research
- Neuroscience of respiration and sleep
- Neuroinflammation and Neurodegeneration Mechanisms
Boston University
2025
China Jiliang University
2024-2025
Institute of Zoology
2024
University of Chinese Academy of Sciences
2024
Chinese Academy of Sciences
2024
Luye Pharma (China)
2023
Iowa State University
2022
China Pharmaceutical University
2021-2022
Jilin University
2019-2022
Dalian Ocean University
2021
The Rho-family GTPase Rac1 activates the WAVE regulatory complex (WRC) to drive Arp2/3 complex-mediated actin polymerization in many essential processes. binds WRC at two distinct sites-the A and D sites. Precisely how binding triggers activation remain unknown. Here we report structures by itself, when bound single or double molecules, ~3 Å resolutions cryogenic-electron microscopy. reveal that sites mechanisms, site, but not drives activation. Activation involves a series of unique...
Brain disturbances, like injuries or aberrant protein deposits, evoke nucleotide release leakage from cells, leading to microglial chemotaxis and ingestion. Recent studies have identified P2Y12 purinergic receptors as triggers for P2Y6 mediators phagocytosis. However, pinocytosis, known the internalization of fluid-phase materials, has received much less attention. We found that ATP efficiently triggered pinocytosis in microglia. Pharmacological analysis knockdown experiments demonstrated...
Abstract The neuropathologic abnormalities associated with Prader–Willi syndrome (PWS) are largely unknown. PWS is due to the loss of several paternally expressed genes in chromosome 15q11‐q13 region. Several imprinted region normally brain and thought be necessary for neuronal growth development. Thus, we hypothesized that would find gray white matter individuals PWS. We evaluated three‐dimensional (3‐D) MRI scans 20 PWS, aged three months 39 years, compared them 3‐D 21 normal weight...
Abstract Prader–Willi syndrome (PWS) is a well‐defined of childhood‐obesity which can serve as model for investigating early onset childhood obesity. Many the clinical features PWS (e.g., hyperphagia, hypogonadotropic hypogonadism, growth hormone deficiency) are hypothesized to be due abnormalities hypothalamus and/or pituitary gland. Children who become severely obese very in life (i.e., before age 4 years) may also have genetic etiology their obesity, perhaps with associated neuroendocrine...
The basal ganglia (BG) are an evolutionarily conserved and phylogenetically old set of sub-cortical nuclei that guide action selection, evaluation, reinforcement. entopeduncular nucleus (EP) is a major BG output contains population GABA/glutamate cotransmitting neurons (EP Sst+ ) specifically target the lateral habenula (LHb) whose function in behavior remains mysterious. Here, we use probabilistic switching task requires animal to maintain flexible relationships between selection evaluation...
Adaptive changes in respiratory and cardiovascular responses at high altitude (HA) have been well clarified. However, the central mechanisms underlying HA acclimatization remain unclear. Using voxel-based morphometry (VBM) diffusion tensor imaging (DTI) with fractional anisotropy (FA) calculation, we investigated 28 Han immigrant residents (17–22 yr) born raised of 2616–4200 m Qinghai-Tibetan Plateau for least 17 years who currently attended college sea-level (SL). Their family migrated from...
Prader–Willi syndrome (PWS) is a genetic imprinting disorder characterized mainly by hyperphagia and early childhood obesity. Previous functional neuroimaging studies used visual stimuli to examine abnormal activities in the eating‐related neural circuitry of patients with PWS. It was found that PWS exhibited both excessive hunger consistently, even situations without any food stimulation. In present study, we employed resting‐state MRI techniques investigate brain networks related eating...
Abstract As part of a study investigating commonalities between Prader-Willi syndrome (PWS—a genetic imprinting disorder) and early-onset obesity unknown etiology (EMO) we measured total cerebral cerebellar volume on volumetric magnetic resonance imaging (MRI) images. Individuals with PWS (n = 16) EMO 12) had smaller volumes than control group 15 siblings (p .02 vs. EMO; p .0005 PWS), although there was no difference among the groups in volume. also impaired cognitive function: general...
The aim of this study was to propose a prognostic scoring system based on preoperative serum apolipoprotein A-1 and C-reactive protein (ApoA-1 CRP, AC score) levels evaluate the value these markers in patients with hepatocellular carcinoma (HCC). In all, 539 consecutive cases diagnosed HCC from 2009 2012 at Sun Yat-sen University Cancer Center were analysed. characteristics pretreatment lipids (ApoA-1, B (Apo-B), high-density lipoprotein cholesterol (HDL-C), low-density (LDL-C), total (TC),...
The RAC1-WAVE-Arp2/3 signaling pathway generates branched actin networks that power lamellipodium protrusion of migrating cells. Feedback is thought to control lifetime and migration persistence, but its molecular circuitry remains elusive. Here, we identify PPP2R1A by proteomics as a protein differentially associated with the WAVE complex subunit ABI1 when RAC1 activated downstream generation blocked. found associate at lamellipodial edge an alternative form complex, Shell Complex, contains...
An efficient and simple method for determining vanillin, methyl vanillin ethyl in milk dairy products was developed using a liquid-liquid extraction (LLE) procedure coupled to high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS). Different procedures were tested optimised by spiking three compounds into blank matrix which none of any food additives detected, the with acetonitrile solution n-hexane as cleaning sorbent allowed an recovery 87.6–101.7% RSDs less than 5%....
As a crucial target which is overexpressed in variety of cancers, aldo-keto reductase 1C3 (AKR1C3) confers chemotherapeutic resistance to many clinical agents. However, limited number AKR1C3-selective inhibitors are applied clinically, indicates the importance identifying active compounds. Herein, we report discovery, synthesis, and evaluation novel potent AKR1C3 with structural diversity. Molecular dynamics simulations these compounds provide reasonable clarification interpreted biological...
Obesity research has recognized that there are many factors contributing to this devastating disorder. Much debate arisen among scientists develop models might be useful in understanding why obesity become a major health problem and epidemic. However, much of the current been fractious causes have attributed solely behavior or fast food, personality issues, depression, addiction, genetics. One neurohormonal genetic found Prader-Willi syndrome (PWS), which results excessive, pathologic...
The amount, timing, and location of bone morphogenetic protein 2 (BMP2) synthesis influences the differentiation pluripotent mesenchymal cells in embryos adults. BMP2 3′untranslated region (3′UTR) contains a highly conserved AU-rich element (ARE) embedded sequence that commonly represses gene expression cells. Computational analyses indicate this site also may bind several microRNAs (miRNAs). Although miRNAs frequently target regions, ARE is unusual because directly span ARE. We began to...
Multiple myeloma is a heterogeneous disorder and the intratumor genetic heterogeneity contributes to emergency of drug resistance. Dexamethasone has been used clinically for decades MM. Nevertheless, their use severely hampered by risk developing side effects occurrence Dex LncRNA NEAT1 plays oncogenic role participates in resistance many solid tumors. Therefore, we investigated potential usefulness this molecular as biomarker diagnosis MM possible correlations expression with prognosis.Bone...
Background: Serum lipids have been documented as prognostic biomarkers in several types of cancer, however the value serum non-esophageal squamous cell carcinoma (non-ESCC) is not clear. The purpose this study was to investigate roles non-ESCC and establish a novel effective nomogram for overall survival (OS) disease-free (DFS) patients with non-ESCC. Methods: We retrospectively analyzed values pretreatment lipids, including total cholesterol (TC), triglycerides (TG), high-density...