A5082113289- Neuroscience and Neuropharmacology Research
- Cancer and Skin Lesions
- Neural dynamics and brain function
- Genetic Syndromes and Imprinting
- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
- Ear and Head Tumors
- Neuroscience of respiration and sleep
- Olfactory and Sensory Function Studies
- Nonmelanoma Skin Cancer Studies
- Cancer Diagnosis and Treatment
- Neural and Behavioral Psychology Studies
- Photoreceptor and optogenetics research
- Cell Image Analysis Techniques
- Receptor Mechanisms and Signaling
- Genetics and Neurodevelopmental Disorders
- Single-cell and spatial transcriptomics
- Neurogenesis and neuroplasticity mechanisms
- Epigenetics and DNA Methylation
- Science Education and Pedagogy
- Engineering Education and Pedagogy
- Autoimmune Bullous Skin Diseases
- Hair Growth and Disorders
- Breast Lesions and Carcinomas
- Histiocytic Disorders and Treatments
Boston University
2021-2025
Augusta University
2023
Howard Hughes Medical Institute
2017-2022
Harvard University
2017-2022
University of North Carolina at Chapel Hill
2011-2017
Institut des Sciences Cognitives Marc Jeannerod
2016
Jacksonville College
2014
Mayo Clinic in Florida
2014
WinnMed
2014
Marine Biological Laboratory
2013
The lateral habenula (LHb) is an epithalamic brain structure critical for processing and adapting to negative action outcomes. However, despite the importance of LHb behavior clear anatomical molecular diversity neurons, neuron types remain unknown. Here, we use high-throughput single-cell transcriptional profiling, monosynaptic retrograde tracing, multiplexed FISH characterize cells mouse habenula. We find five subtypes neurons in medial (MHb) that are organized into subregions. In LHb,...
The continued addition of new neurons to mature olfactory circuits represents a remarkable mode cellular and structural brain plasticity. However, the anatomical configuration newly established circuits, types numbers that form synaptic connections, effect sensory experience on connectivity in bulb remain poorly understood. Using vivo electroporation monosynaptic tracing, we show postnatal-born granule cells connections with centrifugal inputs mitral/tufted mouse bulb. In addition, born...
Basket axon collaterals synapse onto the Purkinje soma/axon initial segment (AIS) area to form specialized structures, pinceau, which are critical for normal cerebellar function. Mechanistic details of how pinceau become organized during development poorly understood. Loss cytoskeletal adaptor protein Ankyrin G (AnkG) results in mislocalization cell adhesion molecule Neurofascin (Nfasc) at AIS and abnormal organization pinceau. Nfasc adult neurons leads slow disorganization morphology. Here,...
The basal ganglia (BG) are an evolutionarily conserved and phylogenetically old set of sub-cortical nuclei that guide action selection, evaluation, reinforcement. entopeduncular nucleus (EP) is a major BG output contains population GABA/glutamate cotransmitting neurons (EP Sst+ ) specifically target the lateral habenula (LHb) whose function in behavior remains mysterious. Here we use probabilistic switching task requires animal to maintain flexible relationships between selection evaluation...
The basal ganglia (BG) are an evolutionarily conserved and phylogenetically old set of sub-cortical nuclei that guide action selection, evaluation, reinforcement. entopeduncular nucleus (EP) is a major BG output contains population GABA/glutamate cotransmitting neurons (EP Sst+ ) specifically target the lateral habenula (LHb) whose function in behavior remains mysterious. Here, we use probabilistic switching task requires animal to maintain flexible relationships between selection evaluation...
Syringomas may be at least partially under estrogen and/or progesterone influence, as they are more common in women and known to proliferate puberty. During pregnancy the premenstrual period an increase tumor size has also been described. We examined nine syringomas using immunohistochemical markers for (ER) (PR) receptors. Scattered cells displaying nuclear cytoplasmic staining ER were noted one of cases. Intense PR was most (> 80%) neoplastic 8/9 syringoma Current evidence supports theory...
Genomic imprinting describes an epigenetic process through which genes can be expressed in a parent-of-origin-specific manner. The monoallelic expression of imprinted renders them particularly susceptible to disease causing mutations. A large proportion are the brain, but little is known about their functions. Indeed, it has proven difficult identify cell type-specific due heterogeneity types within brain. Here we used laser capture microdissection visual cortical neurons and found evidence...
Angelman syndrome (AS) is a neurodevelopmental disorder caused by loss of the maternally inherited allele UBE3AUbe3aSTOP/p+ mice recapitulate major features AS in humans and allow conditional reinstatement maternal Ube3a with expression Cre recombinase. We have recently shown that model exhibit reduced inhibitory drive onto layer (L)2/3 pyramidal neurons visual cortex, which contributes to synaptic excitatory/inhibitory imbalance. However, it remains unclear how this affects neural circuits...
Although the neurobiology of rodent facial whiskers has been studied intensively, little is known about sensing in other vibrissae. Here we describe under-investigated submandibular "whisker trident" on rat's chin. In this three-whisker array, a unique unpaired midline whisker laterally flanked by two slightly shorter whiskers. All three point to ground and are curved backwards. Unlike whiskers, trident not located an exposed body part. Trident vibrissae whisked do touch anything over long...
Cutaneous aspergillosis commonly occurs in immunocompromised hosts and may also complicate burn wounds. Pseudoepitheliomatous hyperplasia (PH) is a histologic reaction secondary to wide range of stimuli, including fungal infection. We describe case an 18-year-old man, status-post burns over 70% his total body surface area, with cutaneous the axilla PH. A single PH primary has been described larynx but, our knowledge, never cutaneously. Histologic examination lesion reveals irregularly...
In some situations, hair growth is under hormonal control. Androgenic alopecia characterized as hormonally driven loss in the genetically susceptible individual. During pregnancy, increased, estrogen appears to prolong anagen phase. However, postpartum common, and thus may be related a decrease or progesterone levels. contrast, areata not considered We compared immunohistochemical staining characteristics of nine cases androgenic with those 13 using receptor (ER) (PR) markers. Estrogen...