A5007590410- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Eicosanoids and Hypertension Pharmacology
- Wound Healing and Treatments
- Mesenchymal stem cell research
- Diabetic Foot Ulcer Assessment and Management
- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
Karolinska Institutet
2020-2022
Karolinska University Hospital
2020
Background: Excessive production of mitochondrial reactive oxygen species (ROS) is a central mechanism for the development diabetes complications. Recently, hypoxia has been identified to play an additional pathogenic role in diabetes. In this study, we hypothesized that ROS overproduction was secondary impaired responses due inhibition hypoxia-inducible factor-1 (HIF-1) by hyperglycemia. Methods: The levels were analyzed blood healthy subjects and individuals with type 1 after exposure...
Persistent and impaired inflammation impedes tissue healing is a characteristic of chronic wounds. A better understanding the mechanisms controlling wound needed. In this study, we show that in human wound-edge keratinocytes, expressions microRNA (miR)-17, miR-18a, miR-19a, miR-19b, miR-20a, which all belong to miR-17∼92 cluster, are upregulated during repair. However, their levels lower ulcers than acute wounds at proliferative phase. Conditional knockout keratinocytes as well injection...
Abstract Wound healing is a high energy demanding process that needs good coordination of the mitochondria with glycolysis in characteristic highly hypoxic environment. In diabetes, hyperglycemia impairs adaptive responses to hypoxia profound negative effects on different cellular compartments wound healing. miR-210 hypoxia-induced microRNA regulates metabolism and processes important for Here, we show blunted hypoxia-dependent induction both vitro human mouse diabetic wounds. The impaired...
Abstract Background Excessive production of mitochondrial reactive oxygen species (ROS) is a central mechanism for the development diabetes complications. Recently, hypoxia has been identified to play an additional pathogenic role in diabetes. In this study, we hypothesized that ROS overproduction was secondary impaired responses due inhibition hypoxia-inducible factor-1 (HIF-1) by hyperglycemia. Methods The dynamic levels analysed blood healthy subjects and individuals with type 1 after...