A5045220703- Pediatric Hepatobiliary Diseases and Treatments
- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Liver Diseases and Immunity
- Cholangiocarcinoma and Gallbladder Cancer Studies
- MicroRNA in disease regulation
- Liver Disease and Transplantation
- Neuropeptides and Animal Physiology
- Organ Transplantation Techniques and Outcomes
- Diet, Metabolism, and Disease
- Cancer-related molecular mechanisms research
- Circadian rhythm and melatonin
- Digestive system and related health
- Gallbladder and Bile Duct Disorders
- Pancreatic function and diabetes
- Genetic and Kidney Cyst Diseases
- Circular RNAs in diseases
- Peptidase Inhibition and Analysis
- Alcohol Consumption and Health Effects
- Pancreatitis Pathology and Treatment
- Clinical Nutrition and Gastroenterology
- Pancreatic and Hepatic Oncology Research
- Fibroblast Growth Factor Research
- Extracellular vesicles in disease
Texas A&M University
2015-2024
Central Texas Veterans Health Care System
2012-2023
Texas A&M Health Science Center
2014-2023
Bryan College
2019-2023
University of Rome Tor Vergata
2022
Richard L. Roudebush VA Medical Center
2022
Indiana University – Purdue University Indianapolis
2022
Sapienza University of Rome
2000-2022
Indiana University School of Medicine
2022
Mitchell Institute
1997-2021
Transmembrane protein 173 (TMEM173 or STING) signaling by macrophage activates the type I interferon-mediated innate immune response. The response contributes to hepatic steatosis and non-alcoholic fatty liver disease (NAFLD). We investigated whether STING regulates diet-induced in steatosis, inflammation, fibrosis mice.Mice with disruption of Tmem173 (STINGgt) on a C57BL/6J background, mice without this gene (controls), only myeloid cells were fed standard chow diet, high-fat diet (HFD; 60%...
Injury to the biliary epithelium triggers inflammation and fibrosis, which can result in severe liver diseases may progress malignancy. Development of a type 1 immune response has been linked injury pathogenesis; however, subset patients with atresia, most common childhood cholangiopathy, exhibit increased levels Th2-promoting cytokines. The relationship among different inflammatory drivers, epithelial repair, carcinogenesis remains unclear. Here, we determined that Th2-activating cytokine...
Epigenetic changes are associated with the regulation of transcription key cell regulatory genes [micro RNAs (miRNAs)] during different types liver injury. This study evaluated role methylation-associated miRNA, miR-34a, in alcoholic diseases. We identified that ethanol feeding for 4 weeks significantly up-regulated 0.8% known miRNA compared controls, including miR-34a. Treatment normal human hepatocytes (N-Heps) and cholangiocytes [human intrahepatic biliary epithelial cells (HiBECs)]...
MicroRNAs are endogenous small non-coding RNAs that regulate gene expression and cancer development. A rare population of hepatocellular stem cells (HSCs) holds the extensive proliferative self-renewal potential necessary to form a liver tumour. We postulated specific transcriptional factors might microRNAs subsequently modulate products involved in phenotypic characteristics HSCs. evaluated microRNA human HSCs by microarray profiling, defined target genes functional effects two groups...
Background and Aims Indole is a microbiota metabolite that exerts anti‐inflammatory responses. However, the relevance of indole to human non‐alcoholic fatty liver disease (NAFLD) not clear. It also remains largely unknown whether how acts protect against NAFLD. The present study sought examine association between circulating levels fat content in subjects explore mechanisms underlying actions mice with diet‐induced Approach Results In cohort 137 subjects, were reversely correlated body mass...
The secretin/secretin receptor (SR) axis is up‐regulated by proliferating cholangiocytes during cholestasis. Secretin stimulates biliary proliferation down‐regulation of let‐7a and subsequent up‐regulation the growth‐promoting factor, nerve growth factor (NGF). It not known whether secretin/SR plays a role in subepithelial fibrosis observed Our aim was to determine activation animal models human primary sclerosing cholangitis (PSC). Studies were performed wild‐type (WT) mice with bile duct...
We previously introduced the concept that intrahepatic bile duct epithelial cells, or cholangiocytes, are functionally heterogeneous. This is based on observation secretin receptor (SR) gene expression and secretin-induced cAMP synthesis present in cholangiocytes derived from large (>15 μm diameter) but not small (<15 ducts. In work reported here, we tested hypothesis heterogeneous with regard to proliferative capacity. assessed cholangiocyte proliferation vivo by measurement of...