A5103268015- Lipid metabolism and disorders
- Renal Diseases and Glomerulopathies
- Circular RNAs in diseases
- Chronic Kidney Disease and Diabetes
- Immunotherapy and Immune Responses
- Pharmacological Effects and Toxicity Studies
- Apelin-related biomedical research
- Cannabis and Cannabinoid Research
- Pregnancy and preeclampsia studies
- Hormonal Regulation and Hypertension
- Pancreatitis Pathology and Treatment
- Coenzyme Q10 studies and effects
- Nuclear Receptors and Signaling
- Vitamin C and Antioxidants Research
- Cancer-related molecular mechanisms research
- Dialysis and Renal Disease Management
- Synthesis and Biological Evaluation
- Cancer Immunotherapy and Biomarkers
- Cytokine Signaling Pathways and Interactions
- Monoclonal and Polyclonal Antibodies Research
- Birth, Development, and Health
- Electrolyte and hormonal disorders
- Chemokine receptors and signaling
- Pancreatic function and diabetes
- Advanced Proteomics Techniques and Applications
Southern University of Science and Technology
2024
Jinan University
2021-2024
State Key Laboratory of Kidney Diseases
2015-2022
Chinese People's Liberation Army
2018-2022
Chinese PLA General Hospital
2010-2022
Wuxi Fourth People's Hospital
2022
Cell Technology (China)
2021
Renal inflammation is a critical pathophysiological characteristic of diabetic kidney disease (DKD). The mechanism the inflammatory response complicated, and there are few effective treatments for renal that can be used clinically. Insulin-like growth factor-binding protein 5 (IGFBP5) an important secretory related to fibrosis in several tissues. Studies have shown IGFBP5 level significantly upregulated DKD. However, function its DKD remain unclear. Here, we showed levels were increased...
Focal segmental glomerulosclerosis (FSGS) is a kidney disease that commonly associated with proteinuria and the progressive loss of renal function, which characterized by podocyte injury depletion collapse glomerular capillary segments. The pathogenesis FSGS has not been completely elucidated; however, recent advances in molecular genetics have provided increasing evidence structural functional disruption central to pathogenesis. Here, we identified patient aimed characterize pathogenic gene...
Background/Aims: Chronic inflammation contributes to the development of type 2 diabetes mellitus by targeting insulin receptor substrate protein-1 (IRS-1) signaling pathway. Previous studies showed that Leukemia related protein 16 (LRP16) reduced stimulated glucose uptake in adipocytes impairing IRS-1 We explored mechanism which LRP16 promotes inflammatory response. Methods: screened induced proteins lipopolysaccharide (LPS)-stimulated response using liquid chromatography-mass spectrometry...
Lung cancer remains a global challenge due to high morbidity and mortality rates poor response treatment, there are still no effective strategies solve it. The bispecific antibody (BsAb) is novel antibody, which can target two different antigens mediate specific killing effects by selectively redirecting effector cells the cells. In this study, we combined BsAbs achieve dual-target therapy strategy of EpCAM+ MUC-1+ with affinity specificity. results showed that combination against EpCAM...
Neoantigen reactive T cell (NRT) has the ability to inhibit growth of tumors expressing specific neoantigens. However, due difficult immune infiltration and inhibition tumor microenvironment, therapeutic effect NRT in solid is limited. In this study, we designed cells (7×19 NRT) that can express both interleukin-7 (IL-7) chemokine C-C motif ligand 19 (CCL19) mouse lung cancer cells, evaluated difference anti-tumor between 7×19 conventional cells.