Profile and clinical significance of long non-coding RNA GAS8-AS1 in papillary thyroid microcarcinoma

• DOI: 10.3760/cma.j.issn.1000-6699.2017.08.011
• Publication Date: 2017-08-25
• Authors: Dongxue Zhang; Xin Liu; Zhenwen Chen; Bojun Wei; Guoliang Qiao; Wei Yan; Xiao Zheng; Zhen Wen; Lei Xiu
• Keywords: Clinical Significance

Objective To investigate the expression level and clinical significance of long non-coding RNA(LncRNA) growth arrest specific gene-antisense 1(GAS8-AS1) in papillary thyroid microcarcinoma(PTMC) patients.

Methods We investigated profile GAS8-AS1 tissue samples patients with PTMC as well nodular goiter(NG) by quantitative real-time polymerase chain reaction(RT-qPCR).

Results GAS8-AS1 cancer was down-regulated compared adjacent NG samples(P<0.05). Lower also correlated central cervical lymph node metastasis(CLNM, P<0.05). The area under ROC curve for up to 0.717 3 CLNM prediction(P<0.05).

Conclusion GAS8-AS1 may act a potential biomarker PTC diagnosis prediction. (Chin J Endocrinol Metab, 2017, 33: 687-692)

Key words: Long RNA; GAS8-AS1; Papillary microcarcinomas; Clinical biomarkers