A5009032123- Rheumatoid Arthritis Research and Therapies
- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
- Flavonoids in Medical Research
- Bone Metabolism and Diseases
- Natural product bioactivities and synthesis
- Mesenchymal stem cell research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Computational Drug Discovery Methods
- Bioinformatics and Genomic Networks
- Sirtuins and Resveratrol in Medicine
- Spondyloarthritis Studies and Treatments
- Ovarian function and disorders
- Neurological Disease Mechanisms and Treatments
- Osteoarthritis Treatment and Mechanisms
- Antioxidant Activity and Oxidative Stress
- Cardiovascular Function and Risk Factors
- Ultrasound and Hyperthermia Applications
- Intracerebral and Subarachnoid Hemorrhage Research
- Psoriasis: Treatment and Pathogenesis
- Ferroptosis and cancer prognosis
- Gut microbiota and health
- Research on Leishmaniasis Studies
- Garlic and Onion Studies
- Microscopic Colitis
Panyu District Central Hospital
2022-2024
Guangzhou Medical University
2024
Hunan University of Traditional Chinese Medicine
2023
Shantou University
2019-2022
Shantou University Medical College
2019-2022
Guangdong General Hospital
2020
Abstract To explore the molecular network mechanism of Celastrol in treatment rheumatoid arthritis (RA) based on a novel strategy (integrated systems pharmacology, proteomics, transcriptomics and single-cell transcriptomics). Firstly, potential targets RA genes were predicted through database, Celastrol-RA obtained by taking intersection. Then, transcriptomic data proteomic collected. Subsequently, targets, differentially expressed genes, proteins imported into Metascape for enrichment...
To investigate the regulation mechanism of baicalin on triple negative breast cancer (TNBC)'s biological network by a systematic strategy and cytology experiment.A methodology is utilized to predict potential targets baicalin, collect genes TNBC, analyze TNBC baicalin's network. After analysis performed, experiment, real-time quantitative PCR (qPCR) used validate key processes signaling pathways.After analysis, two networks were constructed analyzed: (1) network; (2) Baicalin-TNBC...
Abstract Resveratrol and quercetin have effects on polycystic ovary syndrome (PCOS). Hence, resveratrol combined with may better it. However, because of the limitations in animal human experiments, pharmacological molecular mechanism quercetin-resveratrol combination (QRC) remains to be clarified. In this research, a systematic approach comprising multiple compound target collection, potential prediction, network analysis was used for comparing characteristic resveratrol, QRC, exploring QRC....
Abstract Objective: To explore the mechanism of Shengmai Yin (SMY) for coronary heart disease (CHD) by systemic pharmacology and chemoinformatics. Methods: Traditional Chinese Medicine Systems Pharmacology Database (TCMSP), traditional medicine integrative database (TCMID) (TCM) Database@Taiwan were used to screen predict bioactive components SMY. Pharmmapper utilized potential targets SMY, TCMSP was obtain known The Genecards OMIM collect CHD genes. Cytoscape then network construction...
Abstract This research utilized the systematic biological and proteomics strategies to explore regulatory mechanism of Danshen Yin Modified (DSYM) on atherosclerosis (AS) network. The traditional Chinese medicine database HPLC was used find active compounds DSYM, Pharmmapper predict potential targets, OMIM GeneCards were collect AS targets. String obtain other protein proteins protein‐protein interaction (PPI) data DSYM genes, proteins. Cytoscape 3.7.1 software construct analyse DAVID is...
Osteoporosis is an important health problem worldwide. Siwu decoction (SWD) and its modification have a good clinical effect on osteoporosis. However, the molecular mechanism of SWD osteoporosis has not been thoroughly explained. A systematic pharmacological methodology was utilized to predict active compounds potential targets SWD, collect genes known analyze SWD's network. Five networks were constructed analyzed: (1) genes' protein-protein interaction (PPI) network; (2) Compound-compound...
Aim. To explore the mechanism of resveratrol in reducing soft tissue damage osteoarthritis (OA) based on network pharmacology. Methods. Pharmmapper was used to predict target resveratrol, OMIM and Genecards were collect OA-related disease genes, David ver 6.8 for enrichment analysis. Then, animal experiments carried out verification. The rat OA model established rats randomly divided into 4 groups: group, low-dose high-dose blank control group follow-up experiments. Hematoxylin-eosin (HE)...
BACKGROUND:Cardiovascular complications, such as diabetic cardiomyopathy (DCM), are the leading cause of death in patients. Shengmai Powder (SMP) was found to have cardioprotective effects. MATERIAL AND METHODS:Based on systematic pharmacological methodology, this research determined genes DCM and known targets SMP, predicted potential compounds constructed networks for performed network analysis. RESULTS:Five were constructed: (1) gene PPI network; (2) Compound-compound target SMP; (3)...
BACKGROUND:With the aging of world's population, incidence osteoporosis (OP) has become a public health problem worldwide concern. Research shows that icariin may have therapeutic effect on OP. MATERIAL AND METHODS:PharmMapper was utilized to predict potential targets icariin. GeneCards and Online Mendelian Inheritance in Man (OMIM) were used for collection OP genes. The STRING database obtain protein-protein interaction (PPI) data. We Cytoscape 3.7.2 construct analyze networks. genes...
To explore the pharmacological mechanism of Liuwei Dihuang decoction (LDD) for diabetic retinopathy (DR).The potential targets LDD were predicted by PharmMapper. GeneCards and other databases used to collect DR genes. Cytoscape was construct analyze network LDD's network, DAVID Gene Ontology (GO) pathway enrichment analysis. Finally, animal experiments carried out verify results systematic pharmacology.Five networks constructed analyzed: (1) genes' PPI network; (2) compound-compound target...
Objective. To explore the therapeutic targets, network modules, and coexpressed genes of Radix Rhei Et Rhizome intervention in cerebral infarction (CI), to predict significant biological processes pathways through pharmacology. differential proteins CI, conduct bioinformatics verification, initially explain possible mechanism CI proteomics. Methods. The TCM database was used potential compounds Rhizome, PharmMapper its targets. GeneCards OMIM were search for CI-related genes. Cytoscape...
Osteoporosis is an important health problem worldwide. Liuwei Dihuang Decoction (LDD) and its main ingredients may have a good clinical effect on osteoporosis. Meanwhile, mechanism for treating osteoporosis needs to be further revealed in order provide basis future drug development.A systematic biological methodology was utilized construct analyze the LDD-osteoporosis network. After that, human transcription data of LDD intervention patients with protein arrays rats were collected. The...
To explore the mechanism of Radix Rhei Et Rhizome (Dahuang, DH) intervention in intracerebral hemorrhage (ICH) based on systematic pharmacology and proteomics strategy.The pharmacological strategies were utilized to find bioactive compounds Rhizome, predict its potential targets, collect ICH's disease genes; then, Cytoscape 3.7.1 software was applied for network construction topology analysis. After that, in-depth analysis data ICH performed complement validate results predictions.A total...