A5033384496- HIV Research and Treatment
- Immune Cell Function and Interaction
- Photonic and Optical Devices
- Hepatitis C virus research
- interferon and immune responses
- Advanced Fiber Optic Sensors
- Advanced Fiber Laser Technologies
- Herpesvirus Infections and Treatments
- Hepatitis B Virus Studies
- Immune Response and Inflammation
- Andrographolide Research and Applications
- Reproductive System and Pregnancy
- Liver Disease Diagnosis and Treatment
- Assisted Reproductive Technology and Twin Pregnancy
- Extracellular vesicles in disease
- Liver physiology and pathology
- Pancreatic function and diabetes
- Autophagy in Disease and Therapy
- Atherosclerosis and Cardiovascular Diseases
- Cytomegalovirus and herpesvirus research
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Semiconductor Lasers and Optical Devices
- RNA Interference and Gene Delivery
- Adipokines, Inflammation, and Metabolic Diseases
Boai Hospital of Zhongshan
2023-2024
Southern Medical University
2023-2024
United States Department of State
2022
Temple University
2011-2021
Tianma Microelectronics (China)
2020-2021
Wuhan University
2011-2020
Johnson University
2020
Rutgers, The State University of New Jersey
2020
Creative Research Enterprises (United States)
2017
University of Utah
2016
The in vitro cytotoxicities of the ethanol extract Andrographis paniculata (APE) and its main diterpenoid components were evaluated various cancer cells. APE was found to be significantly growth inhibitory human acute myeloid leukemic HL-60 cells with an IC50 value 14.01 μg/mL after 24 h treatment. Among three diterpenoids A. paniculata, andrographolide exhibited highest degree cytotoxicity followed by deoxyandrographolide while neoandrographolide least effective. Laser confocal microscopy...
A novel, low-cost, and simple dual-parameter measurement scheme based on a cascaded optical fiber device composed of long-period grating (LPFG) an S taper Mach-Zehnder interferometer (SFT-MZI) is proposed demonstrated. The crosstalk problem solved as different resonance peaks the LPFG MZI possess refractive index (RI) temperature sensitivities. Experimental results show distinctive spectral sensitivities -52.57 nm/refractive unit (RIU) 45.87 pm/°C by LPFG, 311.48 nm/RIU (in RI range...
(−)-Epigallocatechin gallate (EGCG) is a major polyphenol component of green tea that has antioxidant activities. Lipopolysaccharide (LPS) induces inflammatory cytokine production and impairs blood–brain barrier (BBB) integrity. We examined the effect EGCG on LPS-induced expression cytokines in human cerebral microvascular endothelial cells (hCMECs) BBB permeability. The TNF-α, IL-1β monocyte chemotactic protein-1 (MCP-1/CCL2) was determined by quantitative real time PCR (qRT-PCR) ELISA....
A novel bending vector sensor based on spatial cascaded orthogonal long period fiber gratings (SCO-LPFGs) written by high-frequency CO(2) laser pulses has been proposed, and two-dimensional sensing characteristics the simple SCO-LPFGs have experimentally demonstrated. three-dimensional coordinate system established, measurement results of proposed above is given, furthermore both curvature bending-direction could be intuitively solved according to coordinates. The research work presented in...
Electronic cigarette (e-cig) use has recently been implicated in promoting atherosclerosis. In this study, we aimed to investigate the mechanism of e-cig exposure accelerated atherosclerotic lesion development. Approach and Results: Eight-week-old ApoE-/- mice fed normal laboratory diet were exposed vapor (ECV) for 2 hours/day, 5 days/week 16 weeks. We found that ECV significantly induced lesions as examined by Oil Red O staining greatly upregulated TLR9 (toll-like receptor 9) expression...
Herpes simplex virus Type I (HSV-1) is a neurotropic that capable of infecting not only neurons, but also microglia and astrocytes can establish latent infection in the central nervous system (CNS). We investigated whether IFN lambda (IFN-λ), newly identified member family, has ability to inhibit HSV-1 primary human neurons. Both neurons were found be highly susceptible infection. However, upon IFN-λ treatment, replication both was significantly suppressed, which evidenced by reduced...
A hybrid optical fiber structure of two cascading long-period gratings (LPFGs), respectively, inscribed on a segment few-mode (FMF) and single-mode (SMF), is proposed experimentally demonstrated. This could be used for simultaneous measurement strain temperature. The FMF-LPFG exhibits an opposite temperature response higher sensitivity compared to that the SMF-LPFG, which can improve resolutions. Experimentally, sensitivities sensor are -2.9 pm/με -17.6 pm/°C, FMF-LPFG; these -1.47 46.4...
A microfiber-enabled Fabry-Pérot interferometer (FPI) constructed by splicing a section of microfiber between two cleaved standard single-mode fibers (SMFs) with unique relative fiber cross relationship has been proposed and experimentally demonstrated. The opening air cavity the SMF ends connected serves as an FP also direct sensing head. characteristics FPIs different lengths diameters have studied. force sensitivity high 167.41 nm/N (~200 pm/με) refractive index (RI) 1330.8 nm/RIU (around...
Chitosan is considered to be a very promising biopolymer for various biomedical and pharmaceutical uses because of its nontoxic biocompatible natures (Chandy T, Shama P. Biomater Artif Cells Org 1990;18:1-24). In this study, we prepared porous chitosan scaffolds by lyophilization solution. The were modified with water-soluble polyanionic species such as alginate heparin. pore structures these viewed via light scanning electron microscopy. have high porosity approximately 90% mean sizes from...
Abstract Toll‐like receptors (TLRs) play an essential role in initiating intracellular type I interferon (IFN)‐mediated innate immunity against viral infections. We examined whether human neuronal cells (primary neurons, NT2‐N and CHP‐212 cells) express TLRs mount IFN‐mediated herpes simplex virus‐1 (HSV‐1) infection. Human expressed TLR family members 1–10 IFN‐α/β. The activation of TLR3 or TLR8 by double‐stranded RNA (poly‐I:C) single‐stranded (ssRNA) induced IFN‐α/β expression. In...
A fiber in-line Mach-Zehnder interferometer is fabricated by selectively filling liquid into one air hole of the innermost layer a photonic crystal (PCF). The refractive index so close to that background silica in wavelength range 1300-1600 nm two-mode PCF evolves multimode with an elliptically shaped core. Due different propagation constants, interference can occur between fundamental mode and higher-order modes liquid-filled PCF. Such device applied temperature strain measurements high...
As a rich source of CD4+ T cells and macrophages, the gastrointestinal (GI) tract is major target site for HIV infection. The interplay between GI-resident macrophages intestinal epithelial (IECs) constitutes an important element GI innate immunity against pathogens. In this study, we investigated whether human IECs have ability to produce antiviral factors that can inhibit infection macrophages. We demonstrated possess functional toll-like receptor 3 (TLR3), activation which resulted in...
Background Opioids exert a profound influence on immunomodulation and enhance HIV infection replication. However, the mechanism(s) of their action remains to be determined. We thus investigated impact morphine intracellular innate antiviral immunity. Methodology/Principal Findings Seven-day-cultured macrophages were infected with equal amounts cell-free Bal or SIV DeltaB670 for 2 h at 37°C after 24 treatment without morphine. Effect HIV/SIV replication was evaluated by RT activity assay...
A novel in-fiber Mach-Zehnder interferometer formed by a microfiber-assisted U-shape cavity (MFA-USC) with ultrahigh refractive index (RI) sensitivity and an ultra-wide RI measurement range is demonstrated. The MFA-USC fabricated splicing section of micro-fiber (diameter ~ 63 μm, length 688 μm) tapered from single-mode fiber (SMF) between two sections SMF designed geometry relationship. An (higher than 126 000 nm/RIU at 1.445) within 1.320-1.446 1.462-1.738 has been experimentally achieved....
The RIG-I signaling pathway is critical in the activation of type I IFN-dependent antiviral innate-immune response. We thus examined whether can inhibit HIV replication macrophages. showed that stimulation monocyte-derived macrophages with 5'ppp-dsRNA, a synthetic ligand for RIG-I, induced expression IFN-α/β, and several IRFs, key regulators IFN pathway. In addition, multiple intracellular HIV-restriction factors, including ISGs, members APOBEC3 family, tetherin CC chemokines, ligands entry...
Abstract Toll‐like receptor 3 (TLR3) recognizes double‐stranded RNA and induces type I interferon (IFN)‐mediated antiviral immunity against a number of viral infections. Type III IFN (IFN‐λ) is newly identified cytokine that has biological functions similar to those IFNs. We thus investigated the role IFN‐λ in TLR3 activation‐mediated inhibition herpes simplex virus 1 (HSV‐1) human primary astrocytes. Human astrocytes express endogenous IFN‐λ1 complex, interleukin‐28 α subunit (IL‐28Rα),...
Abstract (−)-Epigallocatechin-3-gallate (EGCG), a major polyphenol component of green tea, has recently been identified as an inhibitor hepatitis C virus (HCV) entry. Here, we examined whether EGCG can enhance hepatocyte-mediated intracellular innate immunity against HCV. HCV dsRNAs (Core, E1-P7, NS-3′NTR and NS5A) induced interferon-λ1 (IFN-λ1) expression in human hepatocytes. These also the Toll-like receptor 3 (TLR3), retinoic acid-inducible gene I (RIG-I) several antiviral IFN-stimulated...
An ultracompact optical fiber sensor based on an S taper Mach-Zehnder interferometer (SFT-MZI) embedded in Bragg grating (FBG) is proposed and experimentally demonstrated for simultaneous force temperature measurement. Experimental results show distinctive spectral sensitivities of -48.56842 nm/N (~54.97 pm/με) 14.71 pm/°C by the SFT-MZI, 1.30588 10.13 FBG. The exhibiting opposite response as compared with that FBG, highly sensitive to force. calculated matrix agree well actual experiment.