A5115594511- Advanced biosensing and bioanalysis techniques
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Molecular Biology Techniques and Applications
- RNA Research and Splicing
- Nanocluster Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Hydrocarbon exploration and reservoir analysis
- CRISPR and Genetic Engineering
- Blood Pressure and Hypertension Studies
- Photonic and Optical Devices
- Gene expression and cancer classification
- Microstructure and mechanical properties
- Gold and Silver Nanoparticles Synthesis and Applications
- Biosensors and Analytical Detection
- Nuclear Structure and Function
- Metal Alloys Wear and Properties
- Metallurgy and Material Forming
- Optical Wireless Communication Technologies
- Retinal Development and Disorders
- Optimal Experimental Design Methods
- Photosynthetic Processes and Mechanisms
- Innovative Microfluidic and Catalytic Techniques Innovation
- 2D Materials and Applications
- Circular RNAs in diseases
Hebei University of Technology
2024-2025
Southwest University
2022-2025
Southern University of Science and Technology
2024
National University of Defense Technology
2023-2024
Chongqing University
2021-2024
Fu Wai Hospital
2001-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2001-2024
Zhejiang University
2024
Nanjing University of Science and Technology
2024
Dalian Maritime University
2024
Binary titanium-niobium (Ti-Nb) alloys have recently been attracted due to low Young's moduli and non-toxic properties. This study explores the influence of Nb content (0-25 wt%) on comprehensive parameters tensile stress-strain relationships (ultimate strength (σUTS), yield (σ0.2) elastic modulus (E)), surfaces properties (Vickers microhardness, surface roughness (Ra), water contact angle (WCA), X-ray diffraction (XRD) scanning electron microscopy (SEM)), corrosion resistance (in artificial...
P2X receptors are ATP-activated cation channels, and the P2X4 subtype plays important roles in immune system central nervous system, particularly neuropathic pain. Therefore, of increasing interest as potential drug targets. Here, we report cryo-EM structures zebrafish receptor complex with two subtype-specific antagonists, BX430 BAY-1797. Both antagonists bind to same allosteric site located at subunit interface top extracellular domain. Structure-based mutational analysis by...
Engineering of multivariate biosensing and imaging platforms involved in disease plays a vital role effectively discerning cancer cells from normal facilitating reliable targeted therapy. Multiple biomarkers such as mucin 1 (MUC1) nucleolin are typically overexpressed breast compared to human epithelium cells. Motivated by this knowledge, dual-responsive DNA tetrahedron nanomachine (drDT-NM) is constructed through immobilizing two recognition modules, MUC1 aptamer (MA) hairpin H1* encoding...
To address the limitations of typical hairpin-structural molecular beacons, exploring ability a quasi-molecular beacon (qMB) to create label-free fluorescence biosensors is intriguing and remains challenge. Herein, we propose first example modular qMB with feature stimulation-responsive conformation switch develop an aggregated Ag nanocluster (aAgNC) in bifurcated DNA scaffold for fluorescently sensing specific initiator (I*). This was well designed program four functional modules:...
Multiplex biomolecular analysis with inductively coupled plasma mass spectrometry (ICP-MS) becomes increasingly important in clinical diagnosis and single cell analysis. However, the sensitivity of ICP-MS-based immunoassay is only comparable or lower than those fluorescence methods at present stage. Therefore, designing elemental tags a large number metal atoms necessary to achieve high-sensitive detection. In this work, we proposed new strategy build up tag loading hundreds rare earth ions...
Proximity-localized catalytic hairpin assembly (plCHA) is intriguing for rapid and sensitive assay of an HIV-specific DNA segment (T*). Using template-integrated green Ag nanoclusters (igAgNCs) as emitters, herein, we report the first design a T*-activated plCHA circuit that confined in three-way-junction architecture (3WJA) fluorescence sensing T*. To this end, T*-recognizable complement programmed stem-loop (H1), two split template sequences igAgNCs are separately overhung contiguous to...
Full-Heusler alloys (fHAs) exhibit high mechanical strength with earth-abundant elements, but their metallic properties tend to display small electron diffusion thermopower, limiting potential applications as excellent thermoelectric (TE) materials. Here, it is demonstrated that the Co-based fHAs Co2 XAl (X = Ti, V, Nb) relatively performance due spin and charge coupling. Thermopower contributions from different magnetic mechanisms, including fluctuation magnon drag are extracted. A...
The DNA frame structure as a natural shell to stably shield the sequence-templated Ag nanocluster core (csAgNC) is intriguing yet challenging for applicable fluorescence biosensing, which elaborate programming of cluster scaffold inside DNA-based cage guide csAgNC nucleation might be crucial. Herein, we report first design symmetric tetrahedral nanocage (TDC) that was self-assembled in one-pot process using C-rich template strand and four single strands. Inside as-constructed soft TDC...
The reaction kinetics and yield of traditional DNA assembly with a low local concentration in homogeneous solution remain challenging. Exploring confined catalytic (CCDA) is intriguing to boost the rate efficacy for creating rapid sensitive biosensing platforms. A rolling circle amplification (RCA) product containing multiple tandem repeats natural scaffold capable guiding periodic customized functional probes at precise sites. Here, we present RCA-confined CCDA strategy speed up amplifiable...
<title>Abstract</title> While microbial cells have emerged as a versatile platform for the synthesis of metal nanoparticles, their application production single-atom catalysts (SACs) has been rarely studied yet. Here, we develop facile method ambient SACs with high loading >4.0 wt% by in-situ reduction ions on overexpressing catalytically active enzyme (e.g., alcohol dehydrogenase (ADH), amine and monoamine oxidase), producing chemo-bio bifunctional (SAC@cell). The ADH-overexpressed...
Abstract Metalens has shown its significantly ultra-light and ultra-thin features. However, large-aperture achromatic metalens is constrained by both maximum dispersion range computational memory. Here, we propose a fully device optimizing framework that engineers phase amplitude transmittance to create centimeter-size operating in long-wave infrared regime (8–12 μm). Via wrapping group delay within defined of desired wavelengths, chromatic aberrations can be effectively corrected. We verify...
A novel red-NIR probe (SWJT-8) for detecting acrolein by utilizing the Michael addition reaction was developed. SWJT-8 exhibits a series of unique advantages, such as colorimetric discrimination, high selectivity and fastest response. And this has been successfully applied to detection intracellular acrolein.
Ratiometric assays of label-free dual-signaling reporters with enzyme-free amplification are intriguing yet challenging. Herein, yellow- and red-silver nanocluster (yH-AgNC rH-AgNC) acting as bicolor ratiometric emitters guided to site-specifically cluster in two template signaling hairpins (yH rH), respectively, originally, both them almost non-fluorescent. The predesigned complement tethered yH is recognizable a DNA trigger (TOC) related SARS-CoV-2. With the help an enhancer strand (G15E)...
A combinatorial immunoassay method for biomarker detection based on a stable isotope tagging strategy was proposed.
Combination of surface enhanced Raman scattering and multivariate statistical method allows to identify distinguish three subtypes non-small-cell lung cancer cells leukocytes on the single-cell level.
Exploring the replication of hybridization chain reaction HCR (rHCR) for reciprocal amplification is intriguing in biosensing and bioanalysis. Herein, we develop a rHCR-based fluorescence platform that manipulated by combination specific DNA trigger (T) T-analogous amplicon (T*), thereby concatenating multi green-emissive Ag nanoclusters (mgAgNCs) amplifiable signal readout. Four well-designed hairpins (H1 recognizing T, H2, H3, H4) with sequential complements are executed to operate rHCR....