A5026253216- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Adipokines, Inflammation, and Metabolic Diseases
- Advanced Sensor and Energy Harvesting Materials
- Advanced Glycation End Products research
- Liver Disease Diagnosis and Treatment
- Conducting polymers and applications
- Sleep and Wakefulness Research
- Muscle metabolism and nutrition
- Electrochemical sensors and biosensors
- Polymer crystallization and properties
- Eicosanoids and Hypertension Pharmacology
- Osteoarthritis Treatment and Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Cannabis and Cannabinoid Research
- Analytical Chemistry and Sensors
- Biotin and Related Studies
- Endoplasmic Reticulum Stress and Disease
- Heme Oxygenase-1 and Carbon Monoxide
- Nanoplatforms for cancer theranostics
- Chronic Kidney Disease and Diabetes
- Fatty Acid Research and Health
- Exercise and Physiological Responses
- Metabolism and Genetic Disorders
- Advanced biosensing and bioanalysis techniques
Wonkwang University
2023-2024
Ewha Womans University
2017-2022
In-Q-Tel
2019
Sichuan University
2008
// Guideock Kwon 1, * , Md Jamal Uddin Gayoung Lee 1 Songling Jiang Ahreum Cho Jung Hwa Sae Rom 2 Yun Soo Bae Sung Hwan Moon 3 Jin Dae Ryong Cha 4 and Hunjoo Ha Graduate School of Pharmaceutical Sciences, College Pharmacy, Ewha Womans University, Seoul, Korea Department Life Science, Aptabio Therapeutics Inc, Yongin-si, Internal Medicine, Division Nephrology, These authors contributed equally to this work Correspondence to: Ha, email: hha@ewha.ac.kr Keywords: APX-115, diabetic kidney...
Src family kinases (SFKs) have been implicated in the pathogenesis of kidney fibrosis. However, specific mechanism by which SFKs contribute to progression diabetic disease (DKD) remains unclear. Our preliminary transcriptome analysis suggested that SFK expression was increased kidneys and Fyn (a member SFKs), along with genes related unfolded protein responses from endoplasmic reticulum (ER) stress signaling pathway, upregulated tubules human kidneys. Thus, we examined whether SFK-induced ER...
Non-alcoholic fatty liver disease (NAFLD) has been increasing in association with the epidemic of obesity and diabetes. Peroxisomes are single membrane-enclosed organelles that play a role metabolism lipid reactive oxygen species. The present study examined peroxisomes high-fat diet (HFD)-induced NAFLD using fenofibrate, peroxisome proliferator-activated receptor α (PPARα) agonist.
Irisin is an exercise-induced myokine, suggested to exert beneficial effects on metabolism. However, the studies regulation of irisin secretion and expression its precursor FNDC5 have shown conflicting data. The discrepancies among previous correlation in humans are related heterogeneity study population. fact that not only a myokine but also adipokine leads further complexity role metabolic regulation. In this study, we examined circulation both type 1 2 diabetic mice, their potential...
Background Non-alcoholic fatty liver disease (NAFLD) has been increasing in association with the epidemic of obesity and diabetes. Peroxisomes are single membrane-enclosed organelles that play a role metabolism lipid reactive oxygen species. The present study examined peroxisomes high-fat diet (HFD)-induced NAFLD using fenofibrate, peroxisome proliferator-activated receptor α (PPARα) agonist. Methods Eight-week-old male C57BL/6J mice were fed either normal or HFD for 12 weeks, fenofibrate...
Abstract Diabetic kidney disease (DKD) is the leading cause of end-stage disease. Epidemiological studies have demonstrated that cigarette smoke or nicotine a risk factor for progression chronic injury. The present study analyzed toxicity in experimental rats with DKD. Experimental diabetes was induced 7-week-old Sprague-Dawley by single intraperitoneal injection streptozotocin (60 mg kg−1). Four weeks after induction diabetes, were exposed to (200 μg L−1), 4 h daily, and 5 days per week...
An electrochemical sensor sensitive to coenzyme A (CoA) was designed using a CoA-responsive polyallylamine-manganese oxide-polymer dot nanogel coated on the electrode surface detect various genetic models of osteoarthritis (OA). The responded abundance CoA in OA, causing breakage MnO
In this study, we report the rejuvenation of aged muscle fibers facilitated by heterochronic parabiosis, underscored a notable upregulation in peroxisomal gene expression. Our findings highlight pivotal role dysregulation biogenesis and consequential impairment fatty acid β-oxidation myoblast differentiation regeneration. Notably, demonstrate novel therapeutic strategy that involves administration peroxisome-COS-FITC complexes nanozymes mimic function, effectively rejuvenating tissues. This...
Aims: Peroxisome is a critical organelle for fatty acid oxidation (FAO) and metabolism of reactive oxygen species (ROS). Increased oxidative stress in adipose tissue contributes to the development insulin resistance metabolic syndrome obesity. This study aimed investigate role peroxisomal fitness maintaining adipocyte function, which has been under-rated obesity research area. Results: Reduced gene expressions white (WAT) obese mice suggested close correlation between peroxisomes Peroxisomal...
A coenzyme (CoA-SH)-responsive dual electrochemical and fluorescence-based sensor was designed utilizing an MnO2-immobilized-polymer-dot (MnO2@D-PD)-coated electrode for the sensitive detection of osteoarthritis (OA) in a peroxisomal β-oxidation knockout model. The CoA-SH-responsive MnO2@D-PD-coated interacted sensitively with CoA-SH OA chondrocytes, triggering electroconductivity fluorescence changes due to cleavage MnO2 nanosheet on electrode. can detect immature articular chondrocyte...
Background: Increased oxidative stress in adipose tissue is critical for the development of insulin resistance and metabolic syndrome obesity. Peroxisomes are involved fatty acid oxidation removal reactive oxygen species, but importance peroxisome homeostasis poorly understood. This study aimed to determine peroxisomal biogenesis
Peroxisome is a critical organelle for fatty acid oxidation (FAO) and metabolismof reactive oxygen species (ROS). Increased oxidative stress in white adiposetissue (WAT) crucial the development of insulin resistance metabolicsyndrome obesity. The present study aimed to investigate role ofperoxisomal fitness maintaining adipocyte function. Reduced adiposeperoxisomal genes obesity suggested close correlation between peroxisomesand Pex5 siRNA increased cellular ROS inflammatory mediators...
Abstract Background and Aims Sarcopenia physical inactivity synergistically progress in patients with chronic kidney disease (CKD). is also strongly associated the risk of mortality end-stage disease. Exercise improves skeletal muscle mass strength, PGC-1α significantly upregulated after exercise. Since CKD have limitation to exercise, present study aimed find natural compounds that mimic Dojuksan, a traditional decoction was confirmed increase expression c2c12 cells. Method Unilateral...