A5091873351- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Inflammasome and immune disorders
- Advanced Glycation End Products research
- Liver Disease Diagnosis and Treatment
- IL-33, ST2, and ILC Pathways
- Fatty Acid Research and Health
- Antioxidant Activity and Oxidative Stress
- Metabolomics and Mass Spectrometry Studies
- Dialysis and Renal Disease Management
- Natural product bioactivities and synthesis
- Immune Cell Function and Interaction
- Peroxisome Proliferator-Activated Receptors
- Sirtuins and Resveratrol in Medicine
- Diabetes and associated disorders
- Acute Myeloid Leukemia Research
- Advancements in Solid Oxide Fuel Cells
- Renal Diseases and Glomerulopathies
- Adenosine and Purinergic Signaling
- Microwave Dielectric Ceramics Synthesis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Photodynamic Therapy Research Studies
- NF-κB Signaling Pathways
- Calpain Protease Function and Regulation
- Atherosclerosis and Cardiovascular Diseases
Chung-Ang University
2024-2025
Chonnam National University
2012-2023
Ewha Womans University
2006-2012
Mitochondrial reactive oxygen species (ROS) play an important role in diabetes complications, including diabetic nephropathy (DN). Plasma free fatty acids (FFAs) as well glucose are increased diabetes, and peroxisomes mitochondria participate FFA oxidation interconnected fashion. Therefore, we investigated whether deficiency of catalase, a major peroxisomal antioxidant, accelerates DN through dysfunction abnormal renal metabolism. Diabetes was induced by multiple injections low-dose...
Increased oxidative stress and mitochondrial dysfunction in obese adipocytes contribute to adipokine dysregulation, inflammation, insulin resistance.Through an advanced proteomic analysis, we found that peroxiredoxin 3 (Prx3), a thioredoxin-dependent peroxidase, is highly expressed 3T3-L1 compared preadipocytes. Interestingly, db/db mice human subjects, adipose Prx3 levels were significantly decreased, indicating its association with obesity. We therefore employed knockout (KO) transfected...
Non-alcoholic fatty liver disease (NAFLD) is a global clinical problem. The MD2-TLR4 pathway exacerbates NAFLD progression by promoting inflammation. Long-term exercise considered to improve but the underlying mechanism still unclear. In this study, we examined protective effect and molecular of on high-fat diet (HFD)-induced injury. an HFD-induced mouse model, training significantly decreased hepatic steatosis fibrosis. Interestingly, blocked binding downstream inflammatory response. Irisin...
Obesity is associated with chronic low-grade inflammation. The benefits of exercise are partly attributed to its anti-inflammatory effect, but whether can regulate NLRP3 inflammasome activation in obese adipose tissue remains unknown. Meteorin-like (METRNL), a recently discovered myokine, has been implicated mediating the effect on metabolism. Herein, we examined and METRNL activation. High-fat diet (HFD)-induced mice were subjected treadmill for 8 weeks. A subgroup HFD was switched normal...
Irisin is an exercise-induced myokine known to induce adipocyte browning through induction of uncoupling protein 1. Recent studies have reported that irisin also adipokine. However, there limiting evidence on the role endogenous from adipocytes. In this study we aim elucidate expression and secretion pattern during differentiation exogenous adipogenic process. As such, recombinant irisin, plasmid expressing FNDC5 small interfering RNA were utilized. Our results show gene precursor increases...
Background and Purpose Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a challenging clinical that leads to various sequelae even high mortality in patients with severe disease. The novel pharmacological strategies therapeutic drugs are urgently needed. Natural products have played fundamental role provided an abundant pool drug discovery. Experimental Approach A compound library containing 160 natural was used screen potential anti‐inflammatory compounds. Mice...
Obesity is one of the most prevalent chronic diseases worldwide, and dysregulated adipocyte function plays an important role in obesity-associated metabolic disorder. The level plasma plasminogen activator inhibitor-1 (PAI-1) increased obese subjects, PAI-1 null mice show improved insulin sensitivity when subjected to high-fat high-sucrose diet-induced stress, suggesting that a best-in-class inhibitor may become novel therapeutic agent for syndrome. TM5441 orally active does not cause...
Irisin is an exercise-induced myokine, suggested to exert beneficial effects on metabolism. However, the studies regulation of irisin secretion and expression its precursor FNDC5 have shown conflicting data. The discrepancies among previous correlation in humans are related heterogeneity study population. fact that not only a myokine but also adipokine leads further complexity role metabolic regulation. In this study, we examined circulation both type 1 2 diabetic mice, their potential...
Background. Despite the beneficial effects of alagebrium (ALA), a putative advanced glycation end-product (AGE) breaker, on diabetic nephropathy, its renoprotective mechanisms are incompletely understood. Since oxidative stress exacerbates renal injury through interaction with AGE, present study examined antioxidative property ALA in db/db mice, mesangial cells cultured under high glucose or H2O2 and test tube.
Objective Accumulation of visceral fat is one the major risk factors for development cardiovascular disease in peritoneal dialysis (PD) patients. Adiponectin, an adipokine commonly regarded as a negative indicator metabolic disease, reported to be downregulated its gene level end-stage renal Since excessive deposit involved increased reactive oxygen species (ROS), PD solution (PDS) may contribute ROS production, resulting dysregulation adiponectin. In this study, we tested our hypothesis...
The prevalence of nonalcoholic fatty liver disease (NAFLD) has increased with the incidence obesity; however, underlying mechanisms are unknown. In this study, high-resolution metabolomics (HRM) along transcriptomics were applied on animal models to draw a mechanistic insight NAFLD. Wild type (WT) and catalase knockout (CKO) mice fed normal fat diet (NFD) or high (HFD) identify changes in metabolic transcriptomic profiles caused by gene deletion correspondence HFD. Integrated omics analysis...
The adipose tissue NLRP3 inflammasome has recently emerged as a contributor to obesity-related metabolic inflammation. Recent studies have demonstrated that the activation of cleaves gasdermin D (GSDMD) and induces pyroptosis, proinflammatory programmed cell death. However, whether GSDMD is involved in regulation function development obesity-induced disease remains unknown. aim present study was investigate role inflammation well whole-body metabolism using GSDMD-deficient mice fed high-fat...
Abstract Long-term peritoneal dialysis is associated with progressive fibrosis of the peritoneum. Epithelial-mesenchymal transition (EMT) mesothelial cells an important mechanism involved in fibrosis, and TGF-β1 considered central this process. However, targeting currently known TGF-β1-associated pathways has not proven effective to date. Therefore, there are still gaps understanding mechanisms underlying EMT fibrosis. We conducted network-based integrated analysis transcriptomic proteomic...
Obesity is a medical condition in which abnormal or excessive fat accumulates to an extent that associated with various diseases. In our ongoing research figure out natural products anti-obesity effects, phytochemical investigation of the EtOH extract seeds Momordica cochinchinensis was carried out, resulted isolation two major triterpenoid saponins: gypsogenin 3-O-β-d-galactopyranosyl(1→2)-[α-l-rhamnopyranosyl (1→3)]-β-d-glucuronopyranoside (1) and quillaic acid...
Betula platyphylla var. japonica (Betulaceae) has been used traditionally in Asian countries for the treatment of inflammatory diseases. A recent study reported a phenolic compound, platyphylloside from B. platyphylla, that shows inhibition on adipocyte differentiation and induces lipolysis 3T3-L1 cells. Based this finding, we conducted phytochemical analysis EtOH extract bark japonica, which resulted isolation glycosides (1–4). Treatment isolated compounds (1–4) during mouse adipocytes...
Irisin is a myokine primarily expressed in skeletal muscle, known to mediate the beneficial effects of exercise.Irisin was first reported induce adipocyte browning by increasing expression uncoupling protein 1 (UCP1), and subsequent studies have also discovered anti-oxidant, anti-inflammatory, anti-metastatic irisin.Despite controversies on circulating levels irisin, that tested therapeutic potential irisin injecting recombinant shown promising results.Therefore, there need develop means...