A5091457190- Head and Neck Cancer Studies
- Advanced Proteomics Techniques and Applications
- Cancer survivorship and care
- Head and Neck Surgical Oncology
- Metabolomics and Mass Spectrometry Studies
- Ear and Head Tumors
- Peptidase Inhibition and Analysis
- Connexins and lens biology
- Mass Spectrometry Techniques and Applications
- Ubiquitin and proteasome pathways
- Enzyme Production and Characterization
- Collagen: Extraction and Characterization
- Cancer, Hypoxia, and Metabolism
- Salivary Gland Tumors Diagnosis and Treatment
- Protease and Inhibitor Mechanisms
- Heat shock proteins research
- Childhood Cancer Survivors' Quality of Life
- Bone and Dental Protein Studies
- Alzheimer's disease research and treatments
- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Nuclear Materials and Properties
- Molecular Biology Techniques and Applications
- Surgical Simulation and Training
- Nuclear reactor physics and engineering
Washington University in St. Louis
2005-2023
UPMC Central Pa
2016-2020
United Hospital Center
2019
West Virginia University
2019
Barwon Health
2019
Smarter Alloys (Canada)
2017
Hershey (United States)
2015
Southern Illinois University School of Medicine
2004-2013
Core Laboratories (United States)
2013
Alvin J. Siteman Cancer Center
2006-2012
Phosphophoryns (PPs), a family of Asp and Ser(P)-rich dentin proteins, are considered to be archetypal regulators several aspects extracellular matrix (ECM) biomineralization. We have cloned rat incisor PP gene, <i>Dmp2</i>, from our odontoblast cDNA library localized it mouse chromosome 5q21 within 2 centimorgans <i>Dmp1</i>, another tooth-specific ECM protein. The carboxyl-terminal region <i>Dmp2</i> protein (60 residue % Ser, 31 Asp) is divided into two domains, one with unique repetitive...
Background Ideally, disease modifying therapies for Alzheimer (AD) will be applied during the 'preclinical' stage (pathology present with cognition intact) before severe neuronal damage occurs, or upon recognizing very mild cognitive impairment. Developing and judiciously administering such require biomarker panels to identify early AD pathology, classify stage, monitor pathological progression, predict decline. To discover biomarkers, we measured AD-associated changes in cerebrospinal fluid...
Full-length cDNA coding for dentin matrix protein 1 (DMP1) has been cloned and sequenced, but the corresponding complete not isolated. In searching naturally occurring DMP1, we recently discovered that extracellular of bone contains fragments originating from DMP1. Shortened forms termed 37K 57K fragments, were treated with alkaline phosphatase then digested trypsin. The resultant peptides purified by a two-dimensional method: size exclusion followed reversed-phase high performance liquid...
Standardized, comprehensive platforms for the discovery of protease substrates have been extremely difficult to create. Screens specificity are now frequently based on cleavage patterns peptide substrates, which contain small recognition motifs that required scissile bond within an active site. However, these studies do not identify in vivo nor can they lead definition macromolecular features account biological proteases. To use properly folded proteins a proteomic screen we used 2D...
Cerebrospinal fluid (CSF) is a potential source of biomarkers for many disorders the central nervous system, including Alzheimer disease (AD). Prior to comparing CSF samples between individuals identify patterns disease-associated proteins, it important examine variation within over short period time so that one can better interpret changes in as well given individual longer span. In this study, we analyzed 12 samples, composed pairs from six individuals, obtained 2 weeks apart....
Abstract Background The purpose of this study was to determine the feasibility a randomized trial resistance exercise in patients with head and neck cancer receiving radiation. Methods Fifteen radiation were (using bands) or control group. Resistance occurred at therapy site (weeks 1–6) home 7–12). Results No serious adverse events related exercise. Medium large effect size differences favoring versus group noted for perceived fatigue 6 weeks (smaller increase group; 7.4 vs 15.4, [ d ] =...
As proteomic technology evolves, protein staining sensitivity is constantly being improved, enabling researchers to better visualize the proteome of their system. The current challenge balance limits detection visualization with those mass spectrometric methods. In this report, spectra generated from human serum or rat liver proteins stained either colloidal Coomassie blue, Daiichi silver, SYPRO Orange, Red, Ruby, Tangerine are compared. It has been concluded that newest generation...
There are several surgical approaches for resection of parapharyngeal space (PPS) neoplasms. The purpose this study was to evaluate local disease control, facial nerve injury, and need mandibulotomy associated with PPS neoplasms via the transcervical approach submandibular gland excision. A retrospective chart review 33 patients who underwent a neoplasm between October 1991 July 2000 performed. Of patients, 3 developed recurrence after median follow-up 24 months. None experienced paresis or...
Lightbridge Corporation is developing an advanced metallic nuclear fuel capable of increasing the power output and extending cycle length current-generation light water reactors (LWRs). This paper provides a review unique geometry composition its application to uprates in LWRs.
Overweight and obesity threaten the health, functionality quality of life 77.2% men in West Virginia. The purpose this study was to evaluate feasibility effectiveness a 12-week primary care referred telenutrition weight loss intervention. Fifty-nine 40–70-year-old with were randomized either intervention group (n = 29) or an enhanced usual (EUC) 30) group. Participants from both groups prescribed moderate energy restricted diet (500–750 kcal/day below requirements) provided diet-related...
Our aim was to determine exercise preferences among patients with head and neck cancer their associations quality of life, symptom severity, depression, rural residence.This study involved a cross-sectional chart review self-administered survey, 90 outpatients (response rate = 83%).The majority were <65 years old (65%), male (78%), white (96%) stage > or III (81%). Lack preference the most frequent option for counseling source (66%), delivery (47%), variability (52%). Popular specific...
Background Biomarkers are required for pre-symptomatic diagnosis, treatment, and monitoring of neurodegenerative diseases such as Alzheimer's disease. Cerebrospinal fluid (CSF) is a favored source because its proteome reflects the composition brain. Ideal biomarkers have low technical inter-individual variability (subject variance) among control subjects to minimize overlaps between clinical groups. This study evaluates process multi-affinity fractionation (MAF) quantitative label-free...
Basal cell carcinoma is the most common of cutaneous malignancies, accounting for 65 to 75% all skin cancers. The natural history this disease one chronic local invasion. Metastatic basal a rare clinical entity, with reported incidence only 0.0028 0.5%. Approximately 85% metastatic carcinomas arise in head and neck region. We present case that spread parotid gland man who had multiple lesions on his scalp face. also review literature neck, we discuss its epidemiology, etiology,...
The submandibular gland is commonly removed during neck dissection involving sublevel IB. However, removal reduces basal salivary secretion and therapeutic options for minimizing xerostomia. purpose of this study was to determine whether all lymph nodes in IB can be extirpated without removing the gland.Twenty consecutive patients undergoing 33 dissections were prospectively enrolled. Sublevel performed by 3 sequential steps: (1) targeted node groups (preglandular postglandular, prevascular...