A5008944816- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal disorders and treatments
- Advancements in Transdermal Drug Delivery
- Pancreatic function and diabetes
- Contact Dermatitis and Allergies
- Dermatology and Skin Diseases
- Microbial Inactivation Methods
- Ultrasound and Hyperthermia Applications
- Pediatric Hepatobiliary Diseases and Treatments
- Dermatologic Treatments and Research
- Skin and Cellular Biology Research
- Corneal surgery and disorders
- Facial Rejuvenation and Surgery Techniques
- Intraocular Surgery and Lenses
- Body Contouring and Surgery
- Endoplasmic Reticulum Stress and Disease
- Diabetes and associated disorders
- Viral Infections and Vectors
- Ocular Infections and Treatments
- Dermatological and COVID-19 studies
- Analytical Chemistry and Chromatography
- Photoacoustic and Ultrasonic Imaging
- Advanced Biosensing Techniques and Applications
- Diagnosis and Treatment of Venous Diseases
All India Institute of Medical Sciences
2024
Spanish National Cancer Research Centre
2019-2023
Centre for Cellular and Molecular Biology
2010-2022
Centro de Investigación Biomédica en Red de Cáncer
2021
Alcon (United States)
2016-2019
Centre for DNA Fingerprinting and Diagnostics
2016
Singapore Institute of Technology
2016
Genome Institute of Singapore
2016
Government of India
2016
Council of Scientific and Industrial Research
1989-2016
Molecular taxonomy of tumours is the foundation personalised medicine and becoming paramount importance for therapeutic purposes. Four transcriptomics-based classification systems pancreatic ductal adenocarcinoma (PDAC) exist, which consistently identified a subtype highly aggressive PDACs with basal-like features, including ΔNp63 expression loss epithelial master regulator GATA6. We investigated precise molecular events driving PDAC progression emergence basal programme.
Hyaluronic acid-based dermal fillers have gained rapid acceptance for treating facial wrinkles and deep tissue folds. Although their space-filling properties are well understood, this study evaluates the cellular molecular changes in skin, as a secondary effect, following injection of commercially available, 24-mg/ml, cross-linked hyaluronic filler (HYC-24L+) rodent model.Sprague-Dawley rats, aged 2 to 4 months, were injected intradermally with 20 μl HYC-24L+ using linear threading technique...
OBJECTIVES: Premature activation of the digestive protease trypsin within pancreatic parenchyma is a critical factor in pathogenesis pancreatitis. Alterations genes that affect intrapancreatic activity are associated with chronic pancreatitis (CP). Recently, carboxyl ester lipase emerged as trypsin-independent risk gene. Here, we evaluated ( PNLIP ) potential novel susceptibility gene for CP. METHODS: We analyzed all 13 exons 429 nonalcoholic patients CP and 600 control subjects from...
In a previous study, the authors have shown that rather than variants in trypsinogen gene(s), mutations pancreatic secretory trypsin inhibitor (encoded by SPINK1) and cathepsin B (CTSB) are associated with tropical calcific pancreatitis (TCP). Recently, chymotrypsin C (CTRC) diminish its activity or secretion were found to predict susceptibility chronic (CP). The analysed CTRC large, ethnically matched case-control TCP cohort.The sequenced all eight exons flanking regions 584 CP patients...
Association of PRSS1-PRSS2 (rs10273639) and CLDN2-MORC4 (rs12688220 rs7057398) variants with alcohol-related chronic pancreatitis (CP) is established but nonalcoholic CP unclear. We addressed this inconsistency using tropical calcific (TCP) as model.We sequenced 5'-UTR PRSS1 genotyped in 555 patients TCP 801 controls performed association analysis. Gene-gene interaction between p.Asn34Ser SPINK1 p.Leu26Val CTSB was also evaluated.We observed significant rs10273639/rs4726576 (odds ratio [OR]...
Abstract Pancreatic acinar cells rely on PTF1 and other transcription factors to deploy their transcriptional program. We identify NFIC as a NR5A2 interactor regulator of differentiation. binding sites are enriched in ChIP-Sequencing peaks. Nfic knockout mice have smaller, histologically normal, pancreas with reduced gene expression. binds regulates the promoters genes those involved RNA/protein metabolism, pancreata show defective ribosomal RNA maturation. dampens endoplasmic reticulum...
Purpose To compare the delivery performance of a new preloaded intraocular lens (IOL) system (Ultrasert [system U]) with that 2 commercially available systems (iSert S] and Tecnis iTec T]), manual (Monarch III D). Setting Alcon Laboratories, Fort Worth, Texas, USA. Design Experimental study. Methods Freshly excised porcine eyes were randomly assigned to 5 groups 10 each as follows: U, S, T 2.2 mm incision, 2.4 system. Corneal incision size was measured before after delivery. The rate...
The SPINK1 gene, encoding the human pancreatic secretory trypsin inhibitor, is one of major genes involved in predisposition to chronic pancreatitis (CP). In this study we have assessed potential functional impact 11 promoter variants by means both luciferase reporter gene assay and electrophoretic mobility shift (EMSA), using COLO-357 cells as an expression system. were found be separable into three distinct categories on basis results viz loss-of-function, gain-of-function functionally...
The haplotype harboring the SPINK1 c.101A>G (p.Asn34Ser) variant (also known as rs17107315:T>C) represents most important heritable risk factor for idiopathic chronic pancreatitis identified to date. causal contained within this has however remained stubbornly elusive. Herein, we set out resolve enigma by employing a hypothesis-driven approach. First, searched variants in strong linkage disequilibrium (LD) with rs17107315:T>C using HaploReg v4.1. Second, two candidate SNPs visual inspection...
Introduction: Vascular leg ulcers are highly prevalent conditions that have difficult management, a high sanitary cost and an impact on the patient's quality of life. Individualised homoeopathic treatment could be safe affordable therapeutic option for venous ulcers. Case Summary: A 35-year-old male was treated with medication intractable case chronic ulcer. medicine, Silicea, prescribed after thorough case-taking, which led to improvement in subjective objective symptoms. The Modified...
Introduction: Pilonidal sinus is a very common inflammatory disease of the gluteal region. The most site occurrence natal cleft. It can cause discomfort, absence from work and social embarrassment. There no single, widely accepted therapy available for this condition. In cases, treatment option surgical intervention, but recurrences following surgery are common. Case Summary: A 15-year-old male patient reported discharge cavity in cleft along with pain discomfort. Nitric acid, homoeopathic...
The aim of this study was to evaluate whether variations in the glycoprotein 2 gene (GP2) may potentially affect risk chronic pancreatitis.Six hundred sixty-one French white patients (idiopathic pancreatitis, n = 590; familial 42; hereditary 29), 445 Dravidian from India (tropical calcific 306; idiopathic 139), and 962 unrelated healthy subjects (French white, 500; Dravidian, 462) participated case-control association study. entire coding sequence GP2 searched for conventional genetic by...
The study of biochemical signaling pathways is immense importance. Abnormalities in cell have been linked to the development many serious diseases. In this article, author has presented two best-understood eukaryotic cells and illustrated similarities between traditional control engineering tasks, including step disturbance rejection amplification. illustrations shown how directional sensing polarization can be explained using models gradient mechanism Saccharomyces cerevisiae Dictostelium...
Direct determination of functional biomolecular chemistry clinically relevant tissues in vivo is a challenging task. Current approaches, based on tissue retrieval by biopsy and subsequent solubilization, are limited terms accurate representation constituents, reproducibility, retention functionality solubilized biomolecules. Using pool known surfactants, we designed screened large combinatorial library surfactant formulations, which led to the discovery rare synergistic formulations that...
Skin provides an excellent portal for diagnostic monitoring of a variety entities; however, there is dearth reliable methods patient-friendly sampling skin constituents. This study describes the use low-frequency ultrasound as one-step methodology rapid molecules from skin. Sampling was performed using brief exposure 20 kHz to in presence fluid. In vitro porcine assess effectiveness method and its ability sample drugs endogenous epidermal biomolecules Dermal antifungal drug—fluconazole...