A5045691505- Chromosomal and Genetic Variations
- Pancreatitis Pathology and Treatment
- Neuroendocrine regulation and behavior
- Diabetes Treatment and Management
- Infant Health and Development
- Neuroscience and Neuropharmacology Research
- RNA and protein synthesis mechanisms
- Human-Animal Interaction Studies
- Plant Molecular Biology Research
- Genomics and Chromatin Dynamics
- Glycosylation and Glycoproteins Research
- Pharmacological Effects and Assays
- Histone Deacetylase Inhibitors Research
- Nuclear Receptors and Signaling
- Veterinary Pharmacology and Anesthesia
- Neuroblastoma Research and Treatments
- Protein Degradation and Inhibitors
- Cancer, Hypoxia, and Metabolism
- CRISPR and Genetic Engineering
- Developmental Biology and Gene Regulation
- Functional Brain Connectivity Studies
- Hypothalamic control of reproductive hormones
- Plant Virus Research Studies
- Studies on Chitinases and Chitosanases
- Gastrointestinal disorders and treatments
HUN-REN Szegedi Biológiai Kutatóközpont
2017-2024
Institute of Genetics
2017-2024
Hungarian Research Network
2022
Hungarian Academy of Sciences
2017-2018
Eötvös Loránd University
2014-2017
Institute for Soil Sciences
2014-2017
Boston University
2010-2013
Semmelweis University
2009-2011
University of Bristol
2000
Novartis (Switzerland)
1997
The oxytocin system has a crucial role in human sociality; several results prove that polymorphisms of the receptor gene are related to complex social behaviors humans. Dogs' parallel evolution with humans and their adaptation environment made them useful species model interactions. Previous research indicates dogs eligible models for behavioral genetic research, as well. Based on these previous findings, our investigated associations between directed two newly described (−212AG, 19131AG)...
Self-renewal and differentiation of stem cells is one the fundamental biological phenomena relying on proper chromatin organization. In our study, we describe a novel regulator encoded by Drosophila small ovary (sov) gene. We demonstrate that sov required in both germline (GSCs) surrounding somatic niche to ensure GSC survival differentiation. maintains integrity function repressing transposon mobility, not only germline, but also soma. Protein interactome analysis Sov revealed an...
Human digestive carboxypeptidases CPA1, CPA2, and CPB1 are secreted by the pancreas as inactive proenzymes containing a 94-96-amino acid-long propeptide. Activation of procarboxypeptidases is initiated proteolytic cleavage at C-terminal end propeptide trypsin. Here, we demonstrate that subsequent chymotrypsin C (CTRC) induces nearly 10-fold increase in activity trypsin-activated CPA1 whereas unaffected. Other human pancreatic proteases such B1, B2, chymotrypsin-like enzyme-1, elastase 2A,...
The pancreas secretes digestive proenzymes typically in their monomeric form. A notable exception is the ternary complex formed by proproteinase E, chymotrypsinogen C, and procarboxypeptidase (proCPA) cattle other ruminants. In human pig binary complexes of proCPA with proelastases were found. To characterize formation among pancreatic protease zymogens a systematic manner, we performed binding experiments using recombinant CELA2A, CELA3A, CELA3B; chymotrypsinogens CTRB1, CTRB2, CTRC, CTRL1;...
Meeting humans is an everyday experience for most companion dogs, and their behavior in these situations its genetic background of major interest. Previous research our laboratory reported that German shepherd dogs the lack G allele, Border collies A oxytocin receptor gene (OXTR) 19208A/G single nucleotide polymorphism (SNP) was linked to increased friendliness, which suggests although broad traits are affected by variability, specific links between alleles behavioural variables might be...
Human chymotrypsin C (CTRC) plays a protective role in the pancreas by mitigating premature trypsinogen activation through degradation. Mutations that abolish activity or secretion of CTRC increase risk for chronic pancreatitis. The aim present study was to determine whether human undergoes asparagine-linked (N-linked) glycosylation and examine this modification folding function. We abolished potential sites N-linked (Asn-Xaa-Ser/Thr) mutating Asn residues Ser individually combination,...
Nuclear Piwi/Piwi-interacting RNA complexes mediate co-transcriptional silencing of transposable elements by inducing local heterochromatin formation. In Drosophila, sumoylation plays an essential role in the assembly complex; however, molecular mechanism which machinery is recruited to transposon loci poorly understood. Here, we show that Drosophila E3 SUMO-ligase Su(var)2-10 directly binds Piwi protein. This interaction mediated SUMO-interacting motif-like (SIM-like) structure C-terminal...
γ ‐amino butyric acid (GABA) is the major inhibitory neurotransmitter in CNS, mediating fast synaptic transmission, by activating GABA A receptors. However, these GABA‐gated Cl − channels can also be excitatory, causing depolarization, and increasing Ca 2+ entry via voltage‐operated (VOCCs). Evidence exists for excitatory ionotropic receptors anterior pituitary cells, including gonadotropes, but have not been directly characterized their pharmacology remains controversial. Here we measured...
Abstract Background Dopaminergic pathways that influence mood and behaviour are severely affected in cerebral hypoxia. In contrast, hypoxia promotes the differentiation of dopaminergic neurons. order to clarify hypoxic sensitivity key genes, we aimed study their transcriptional regulation context neuroblastoma astrocytoma cell lines exposed 1% Results Quantitative RT-PCR assays revealed transcription both type D3 D4 postsynaptic dopamine receptors (DRD3 DRD4) was induced several fold upon...
Ovarian germline stem cells (GSCs) of Drosophila melanogaster provide a valuable in vivo model to investigate how the adult cell identity is maintained and differentiation daughter regulated. GSCs are embedded into specialized cellular microenvironment, so-called niche. Besides complex signaling interactions between germ niche cells, intrinsic mechanisms, such as chromatin regulation transcriptional control, also crucial decision about self-renewal differentiation. The key regulator gene bag...
Abstract Self-renewal and differentiation of stem cells is one the fundamental biological phenomena relying on proper chromatin organisation. In our study, we describe a novel regulator encoded by Drosophila small ovary (sov) gene. We demonstrate that sov required in both germline (GSCs) surrounding somatic niche to ensure GSC survival differentiation. Sov maintains integrity function repressing transposon mobility, not only germline, but also soma. Protein interactome analysis revealed...