A5022578400- Pneumonia and Respiratory Infections
- Antibiotics Pharmacokinetics and Efficacy
- Osteoarthritis Treatment and Mechanisms
- Iron Metabolism and Disorders
- Bacterial Infections and Vaccines
- Hemoglobinopathies and Related Disorders
- Antibiotic Resistance in Bacteria
- Streptococcal Infections and Treatments
- Inflammatory mediators and NSAID effects
- Respiratory and Cough-Related Research
- Pharmaceutical studies and practices
- Total Knee Arthroplasty Outcomes
- Antimicrobial Resistance in Staphylococcus
- Urinary Tract Infections Management
- Knee injuries and reconstruction techniques
- Rheumatoid Arthritis Research and Therapies
- Bacterial Identification and Susceptibility Testing
- Proteoglycans and glycosaminoglycans research
- Folate and B Vitamins Research
- Effects of Radiation Exposure
- Pneumocystis jirovecii pneumonia detection and treatment
- Pregnancy and preeclampsia studies
- Tendon Structure and Treatment
- Inflammatory Bowel Disease
- Microscopic Colitis
Meiji Pharma Spain
2010-2025
PharmaMar (Spain)
2024
Universidad de León
2005
Institut Català d'Oncologia
2000
Vall d'Hebron Institut de Recerca
2000
European Institute of Oncology
2000
Hellenic Cooperative Oncology Group
2000
Ospedale San Giovanni Bellinzona
2000
Bacterial flagellin has recently been identified as a ligand for Toll-like receptor 5 (TLR5). Human sites known to specifically express TLR5 include macrophages and gastric intestinal epithelium. Because infection of epithelial cells with <i>Salmonella</i> leads an active transport the subepithelial compartment in proximity microvessels, we hypothesized that human endothelial functionally TLR5, thus enabling inflammatory response upon binding translocated flagellin. Endothelial expression...
Abstract Oxidant stress has been implicated in the pathogenesis of inflammatory bowel disease. Antioxidant enzymes, such as superoxide dismutase (SOD), are candidate drugs for modulating this pathogenic factor. This study was designed to determine therapeutic value SOD an experimental model colitis and mechanisms underlying its effects on intestinal inflammation. For that purpose, colitic (trinitrobenzene sulfonic acid-induced) control rats were studied. Groups animals treated with different...
Epidemiological studies are necessary to explore the effect of current pneumococcal conjugate vaccines (PCVs) against antibiotic resistance, including rise non-vaccine serotypes that resistant antibiotics. Hence, epidemiological changes in antimicrobial pattern Streptococcus pneumoniae before and during first year COVID-19 pandemic were studied.In this national surveillance study, we characterised susceptibility a panel antibiotics 3017 clinical isolates with reduced penicillin 2004-20...
ABSTRACT Community-acquired lower respiratory tract infections (CA-LRTIs) treatment is largely empirical as microbiologic testing rarely performed. Here, we provide data of severe CA-LRTI cases requiring hospitalization. We aim to describe the distribution and susceptibility patterns pathogens causing CA-LRTI. analyzed samples from recently admitted patients with CA-LRTIs assess pathogen antibiotic patterns. divided into three groups: no prior healthcare exposure, diagnosed LRTI 48 7 days...
Objective: this study determine the effect of hyaluronic acid on chondrocyte apoptosis, as well variations in nitric oxide levels an experimental model osteoarthritis elicited anterior cruciate ligament section (ACL) a rabbit with two differentiated developmental periods. Methods: apoptosis and quantification (NO) were studied groups 16 animals each. All had both knees operated, but only right treated (HA). In first group treatment was performed five weeks after induction (short term group,...
Modulation of adhesion molecule expression that govern trafficking leukocytes into the inflamed intestine is envisioned as a new strategy for treatment inflammatory bowel disease (IBD). This study was designed to determine impact reducing oxidative stress on molecules and leukocyte recruitment in experimental chronic colitis. For purpose, colitic interleukin-10 knockout wild-type mice were studied. Groups animals treated with Cu/Zn superoxide dismutase (SOD1) 13 mg/kg/d or vehicle either 7...
Iron deficiency (ID), anemia, iron anemia (IDA) and excess (hemoconcentration) harm maternal-fetal health. We evaluated the effectiveness of different doses supplementation adjusted for initial levels hemoglobin (Hb) on maternal status described some associated prenatal determinants. The ECLIPSES study included 791 women, randomized into two groups: Stratum 1 (Hb = 110-130g/L, received 40 or 80mg daily) 2 > 130g/L, 20 40mg daily). Clinical, biochemical, genetic information was collected...
Surveillance studies including antibiotic resistance and evolution of pneumococcal serotypes are critical to evaluate the susceptibility commonly used antibiotics contribution conjugate vaccines against resistant strains.To determine clinical isolates Streptococcus pneumoniae with reduced penicillin a panel during period 2004-20 characterize impact in serotypes.We selected 3017 order minimal inhibitory concentration penicillin, amoxicillin, cefotaxime, erythromycin, levofloxacin oral...
From four southern European countries (Spain, Italy, Portugal, and Greece) 877 Streptococcus pneumoniae isolates were recovered from adult patients with respiratory tract infections between September 2000 March 2001. The antimicrobial susceptibility to 11 antibiotics was determined in a central laboratory. Penicillin resistance high Greece (47.1%) Spain (25.1%) but much lower Portugal (7.9%) Italy (4.8%). On the other hand, erythromycin (38.5%) (36.2%) no statistical difference (29.4%)...
The effectiveness of prenatal iron supplementation improves maternal hematological outcomes, but little research has focused on child outcomes. objective this study was to assess whether adjusted needs children's cognitive functioning.The analyses included a subsample nonanemic pregnant women recruited in early pregnancy and their children aged 4 years (n=295). Data were collected between 2013 2017 Tarragona (Spain). On the basis hemoglobin levels before 12th gestational week, receive...
To study the influence of resistance phenotypes (based on sentinel antibiotics: penicillin and amoxicillin with/without clavulanate) cefuroxime versus cefditoren susceptibility Streptococcus pneumoniae Haemophilus influenzae recovered from children with acute otitis media. Middle ear isolates (193 S. 114 H. influenzae) received in Spanish Reference Laboratory (Instituto de Salud Carlos III) were tested. Antimicrobial to penicillin, clavulanate, was determined by agar dilution using...
The aim of this study was to evaluate the effects penicillin, amoxicillin or erythromycin resistance on in vitro activity oral cephalosporins against Streptococcus pneumoniae pediatric isolates. A total 282 isolates received during 2005 Spanish Reference Pneumococcal Laboratory were tested by agar dilution: 104 strains penicillin-susceptible, 72 intermediate, and 106 resistant. Serotypes 9 14 most troublesome with <10% susceptibility cephalosporins. Cefditoren exhibited highest intrinsic...