A5030856335- MicroRNA in disease regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Advanced Breast Cancer Therapies
- Cancer-related Molecular Pathways
- Ubiquitin and proteasome pathways
- Microtubule and mitosis dynamics
- Protein Degradation and Inhibitors
- Ovarian cancer diagnosis and treatment
- Ferroptosis and cancer prognosis
- Metastasis and carcinoma case studies
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Cell Adhesion Molecules Research
- Gastric Cancer Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- Chronic Lymphocytic Leukemia Research
- Genetic factors in colorectal cancer
- Nutrition, Genetics, and Disease
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Screening and Detection
- Lung Cancer Diagnosis and Treatment
- RNA regulation and disease
Sapienza University of Rome
2013-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2024
Centro di Riferimento Oncologico
2018-2024
Azienda Ospedaliera Sant'Andrea
2016-2024
The Ohio State University
2021-2024
The Ohio State University Wexner Medical Center
2021-2023
Cancer Genetics (United States)
2023
Faculty (United Kingdom)
2023
CTO Andrea Alesini
2021
Resistance to platinum-based chemotherapy is a common event in patients with cancer, generally associated tumor dissemination and metastasis. Whether platinum treatment per se activates molecular pathways linked spreading not known. Here, we report that the ubiquitin-specific protease 1 (USP1) mediates ovarian cancer cell resistance platinum, by regulating stability of Snail, which, turn, promotes dissemination. At level, observed upon treatment, USP1 phosphorylated ATM ATR binds Snail....
miR-223 is an anti-inflammatory miRNA that in cancer acts either as oncosuppressor or oncopromoter, a context-dependent manner. In breast cancer, we demonstrated it dampens the activation of EGF pathway. However, little known on role during onset and progression. expression was decreased luminal HER2 subtypes inversely correlated with patients' prognosis. normal mammary epithelial cells, acted cell autonomously control their growth morphology three-dimensional context. MMTV-Δ16HER2...
Abstract The extracellular matrix (ECM) is an important component of the tumor microenvironment and undergoes extensive remodeling during both initiation progression breast cancer (BC). EMILIN1 ECM glycoprotein, whose function has been linked to metastasis. However, role mammary gland BC development never investigated. In silico molecular analyses human samples from normal showed that expression was lower in tumors than healthy tissue it predicted poor prognosis, particularly HER2-positive...
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease, characterized by an intense desmoplastic reaction that compresses blood vessels and limits nutrient supplies. PDAC aggressiveness largely relies on its extraordinary capability to thrive progress in challenging tumor microenvironment. Dysregulation of the onco-suppressor miR-15a has been extensively documented PDAC. Here, we identified transcription factor Fos-related antigen-2 (Fra-2) as target mediating adaptive mechanism...
Platinum (PT)-resistant Epithelial Ovarian Cancer (EOC) grows as a metastatic disease, disseminating in the abdomen and pelvis. Very few options are available for PT-resistant EOC patients, little is known about how acquisition of PT-resistance mediates increased spreading capabilities EOC. Here, using isogenic cells, genetic pharmacological approaches, patient-derived models, we report that Integrin α6 (ITGA6) overexpressed by cells necessary to sustain ability adhesion-dependent...
Breast cancer ranks as the most prevalent form of globally. Currently, advanced screening methods have significantly improved early detection rates. These achievements led to more non-invasive diagnoses and underscored clinical relevance precursor lesions like flat epithelial atypia (FEA), a histological condition characterized by mild atypical changes in normal epithelium lining mammary ducts. Despite increasing FEA biopsy, our understanding biological behavior this entity remains limited...
Epithelial Ovarian Cancer (EOC) is the most lethal gynecological cancer in developed countries, and development of new strategies to overcome chemoresistance an awaited clinical need. Angiogenesis, blood vessels from pre-existing vasculature, has been validated as a therapeutic target this tumor type. The aim study verify if EOC cells with acquired resistance platinum (PT) treatment display altered angiogenic potential. Using proteomic approach, we identified tissue inhibitor...
Postnatal development of the mammary gland relies on maintenance oriented cell division and apicobasal polarity, both which are often deregulated in cancer. The microtubule (MT) network contributes to control these processes; however, very little is known about impact altered MT dynamics a complex organ role played by MT-interacting proteins such as stathmin. In this study, we report that female stathmin knock-out (STM KO) mice unable nurse their litters due frank impairment development....
Abstract The CDKN1B gene, encoding for the CDK inhibitor p27 kip1 , is mutated in defined human cancer subtypes, including breast, prostate carcinomas and small intestine neuroendocrine tumors. Lessons learned from tumors suggest that mutations could be subclonal, raising question of whether a deeper sequencing approach lead to identification higher numbers patients with mutations. Here, we addressed this analyzed biopsies breast ( n = 396), ovarian 110) head neck squamous carcinoma 202)...
Abstract Epitranscriptomic studies of miRNAs have added a new layer complexity to the cancer field. Although there is fast-growing interest in adenosine-to-inosine (A-to-I) miRNA editing and alternative cleavage that shifts isoforms, simultaneous evaluation both modifications still missing. Here, we concurrently profiled multiple modification types, including A-to-I shifted >13,000 adult pediatric tumor samples across 38 distinct cohorts from The Cancer Genome Atlas Therapeutically...
Summary Human AKTIP and mouse Ft1 are orthologous ubiquitin E2 variant proteins involved in telomere maintenance DNA replication. also interacts with A‐ B‐type lamins. These features suggest that may be implicated aging regulatory pathways. Here, we show cells derived from hypomorph mutant ( kof/kof ) mice exhibit telomeric defects animals develop progeroid traits, including impaired growth, skeletal skin defects, abnormal heart tissue, sterility. We demonstrate a genetic interaction between...
Alterations in extracellular matrix (ECM) components that modulate inflammatory cell behavior have been shown to serve as early starters for multifactorial diseases such fibrosis and cancer. Here, we demonstrated loss of the ECM glycoprotein EMILIN-1 alters context skin during IMQ-induced psoriasis, a disease characterized by prominent infiltrate alteration vessels appear dilated tortuous. Abrogation expression or mutant E933A impairs macrophage polarization leads imbalanced tissue...
Abstract Background Implementation of colorectal cancer (CRC) screening programs increases endoscopic resection polyps with early invasive CRC (pT1). Risk lymph node metastasis often leads to additional surgery, but despite guidelines, correct management remains unclear. Our aim was assess the factors affecting decision-making process in endoscopically resected pT1-CRCs an academic center. Methods We retrospectively reviewed patients undergoing pT1 from 2006 2016. Clinical, endoscopic,...
The p27kip1 protein, mainly known as a negative regulator of cell proliferation, has also been involved in the control other cellular processes, including regulation cytoskeleton dynamics. Notably, these two functions involve distinct protein domains, residing N- and C-terminal halves, respectively. In last decades, reported to interact with microtubule acto-myosin cytoskeletons, both direct indirect ways, overall drawing picture which several factors play their role either synergy or...
Epithelial ovarian cancer (EOC) is a rare, highly lethal disease. In subset of high grade EOC patients, maintenance therapy with the antiangiogenic drug Bevacizumab (BEV) valuable option. To date, no validated predictive or prognostic biomarkers exist for selecting patients that might benefit from BEV treatment.Immunohistochemistry and RT-qPCR evaluated expression seven angiogenesis-related proteins twelve microRNAs angio-signature in treated first line chemotherapy plus (MITO16A/ManGO OV-2...